Central venous catheterization (CVC) is frequently performed in critical care medicine. However, there is a lack of standardized CVC training. The Airway & Catheter Cannulation Education–from Starters to Specialists (ACCESS) course was developed for a systematic airway and catheterization management. A stepwise A to Z approach for safe and successful CVC is the focus of the current review, while providing a guideline for the ACCESS course. In addition, special care for CVC in trauma patients is discussed.