Central Mechanisms of Apomorphine and m-Chlorophenylpiperazine on Synergistic Action for Ejaculation in Rats

Yoshizumi, Masaru; Yonezawa, Akihiko; Kimura, Yukio; Watanabe, Chizuko; Sakurada, Shinobu; Mizoguchi, Hirokazu

doi:10.1016/j.jsxm.2020.10.014

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…injection of sodium pentobarbital (50 mg/kg), and i.t. catheters were implanted into the spinal subarachnoid space, as described previously 17 . The i.t.…”

Section: Methodsmentioning

confidence: 99%

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Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

Yoshizumi,

Ise,

Yonezawa

et al. 2024

Basic Clin Pharma Tox

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Although α1‐adrenoceptor (α1‐AR) antagonists used to treat benign prostatic hyperplasia can cause ejaculation disorders, the aetiology of this adverse event is still controversial. Therefore, we investigated the effects of antagonists with different affinities for α1‐AR subtypes on ejaculatory function and their mechanisms of action in normal rats. In the spontaneous seminal emission (SSE) test, systemically administered prazosin, terazosin, tamsulosin and naftopidil decreased the weight of ejaculated seminal material in a dose‐dependent manner; the potency order was as follows: tamsulosin > terazosin > prazosin > naftopidil. The selective α1D‐AR antagonist BMY7378 had no effect on SSE. Intrathecal tamsulosin and naftopidil did not inhibit SSE. Tamsulosin, the most potent, was ineffective as a single dose and significantly increased seminal vesicle fluid in rats treated for 2 weeks but did not significantly change retrograde ejaculation. These results indicated that the difference in inhibitory potency of the five α1‐AR antagonists against SSE was due to the involvement of α1A‐AR subtypes. Our results further suggested that α1‐AR antagonist‐induced ejaculatory dysfunction at the peripheral level was mainly due to the loss of seminal emission, although some retrograde ejaculation may also be involved.

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“…injection of sodium pentobarbital (50 mg/kg), and i.t. catheters were implanted into the spinal subarachnoid space, as described previously 17 . The i.t.…”

Section: Methodsmentioning

confidence: 99%

“…catheters were implanted into the spinal subarachnoid space, as described previously. 17 The i.t. catheters were made of silicon-coated polyethylene tubing, which was previously tapered into an appropriate size by heating, and then inserted with a length of polyethylene tubing, after laminectomy, between L1 and L2.…”

Section: Intrathecal (It) Catheterizationmentioning

confidence: 99%

Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

Yoshizumi,

Ise,

Yonezawa

et al. 2024

Basic Clin Pharma Tox

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“… 10 As ejaculation is induced by administering apomorphine, this method has been used in the field of evaluating ejaculation performance. 11 It is possible to evaluate erectile function to a certain extent using apomorphine, but the results depend on the presence or absence of ejaculation; therefore, there is a limit to how accurately erectile function can be evaluated. In addition, the number of mountings is sometimes evaluated; however, it is questionable whether it is significantly affected by sexual desire or whether erectile function itself can be evaluated.…”

Section: Experimental Techniques and Animal Species For Research Of E...mentioning

confidence: 99%

“…Another evaluation method for erectile function includes the administration of apomorphine 10 . As ejaculation is induced by administering apomorphine, this method has been used in the field of evaluating ejaculation performance 11 . It is possible to evaluate erectile function to a certain extent using apomorphine, but the results depend on the presence or absence of ejaculation; therefore, there is a limit to how accurately erectile function can be evaluated.…”

Section: Experimental Techniques and Animal Species For Research Of E...mentioning

confidence: 99%

A review of experimental techniques for erectile function researches and development of medical technology using animal erectile dysfunction models in sexual and reproductive medicine

Kataoka

Hotta

Kimura

2023

Reprod Medicine & Biology

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Background Erectile dysfunction (ED) is one of the causes of male infertility and is a disease that requires treatment. The first‐line drugs for ED are phosphodiesterase 5 (PDE‐5) inhibitors, and further treatment options are currently limited. Medical technologies, such as genetic control and regenerative medicine, are developing rapidly. Research on erectile function is progressing rapidly, coupled with technological innovations in other areas. Methods A PubMed search using the keywords “animal (rat, mouse, rabbit, dog, and monkey)” and “erectile” was conducted, and all relevant peer‐reviewed English results were evaluated. Main findings The methods for evaluating erectile function include intracavernous pressure (ICP) measurements, isometric tension studies, and dynamic infusion cavernosometry. Papers also reported various disease model animals for the study of diabetes mellitus, cavernous nerve injury, and drug‐induced ED. Conclusion Basic research on ED treatment has progressed rapidly over the past 20 years. In particular, research on the mechanism of ED has been accelerated by the publication of a study on the evaluation of erectile function using ICP measurements in rats. In addition, molecular biological experimental methods such as polymerase chain reaction (PCR) and western blotting have become relatively easy to perform due to technological progress, thus advancing research development.

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Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

Pfaus,

Antonie,

Dosa

et al. 2023

Psychopharmacology

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Central Mechanisms of Apomorphine and m-Chlorophenylpiperazine on Synergistic Action for Ejaculation in Rats

Cited by 3 publications

References 41 publications

Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

A review of experimental techniques for erectile function researches and development of medical technology using animal erectile dysfunction models in sexual and reproductive medicine

Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

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Central Mechanisms of Apomorphine and m-Chlorophenylpiperazine on Synergistic Action for Ejaculation in Rats

Cited by 3 publications

References 41 publications

Characteristics of α1‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

Characteristics of α1‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

A review of experimental techniques for erectile function researches and development of medical technology using animal erectile dysfunction models in sexual and reproductive medicine

Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

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Product

Resources

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Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats

Characteristics of α₁‐adrenoceptor antagonists‐induced ejaculatory dysfunction on spontaneous seminal emission in rats