Central Mechanisms of Neck Movements in the Human Brain Stem

Sano, Keiji; Yoshioka, Minoru; Ogashiwa, Motohide; Ishijima, Buichi; Ohye, C.; Sekino, Hiroaki; Mayanagi, Yoshiaki

doi:10.1159/000103687

Cited by 11 publications

(4 citation statements)

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“…As reported previously [Sano et al, 1967], the authors have stimulat ed various points in the brain stem in man. Upon electrical stimulation, the subthalamus (the H-field of F orel), the posterior hypothalamus, the red nucleus, the central tegmental tract and the inferior olive all showed EMG discharges and contraction in the sternocleidomastoid and the pos terior neck muscles on the ipsilateral side, accompanied by lateral flexion of the head to the ipsilateral side.…”

Section: Discussionmentioning

confidence: 77%

Stimulation and Destruction of and around the Interstitial Nucleus of Cajal in Man

Sano¹,

Yoshioka²,

Mayanagi³

et al. 1970

Stereotact Funct Neurosurg

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Section: Discussionmentioning

confidence: 77%

Stimulation and Destruction of and around the Interstitial Nucleus of Cajal in Man

Sano¹,

Yoshioka²,

Mayanagi³

et al. 1970

Stereotact Funct Neurosurg

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“…It is noteworthy that L-dopa induced involuntary movement of neck muscles is difficult to prevent by the previous operation, and that spasmodic torticollis is also difficult to cure by ventro-lateral thalamotomy (18).…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Thalamotomy and L-dopa Induced Involuntary Movement in Parkinsonism

Tsukamoto¹,

Gillingham²

1973

Neurol. Med. Chir.(Tokyo)

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Involuntary movement is one of the most disturbing and problematic side effects of L-dopa in the treatment of Parkinsonism. Several attempts have been made to reduce this complication, such as an addition of adjuvant, (4) and use of slow release L-dopa. However, the problem remains unsolved probably because hyperkinesis occurs when the akinesis of Parkinonism is overcorrected by L-dopa and produces hyperkinesis (15).
For more than 15 years we have been treating Parkinsonian patients with stereo tactic thalamotomy or pallidotomy or both and began to use L-dopa since 1968. We found that the previous operation reduces the incidence and severity of L-dopa in duced involuntary movements in the treated limbs suggested by several authors (1) (15) (17) Methods 121Parkinsonian patients have been treated with L-dopa since 1968 usually as in-patients. Among these, 94 cases had undergone stereotactic operation, unilaterally or bilaterally with 126 lesions before the trial of L-dopa. 13 of these cases (10.7%) had some history suggesting encephalitis. After the initial admission for the drug therapy, patients have been followed up in the out-patient clinic in one to six month intervals or by proforma completed by the patient or his relatives.The dosage of L-dopa ranged from 0.5 Gm. to 8.0 Gm. daily with the average of 4.2 Gm. for 60 males and 3.2 Gm. for 59 females. The average interval between the onset of Parkinsonism and the L-dopa therapy was 9.9 years for males and 10.0 years for female group, with the average onset of the disease of 49.0 years old and 51.1 years old respectively. The average dose was 3.9 Gm. daily in the involuntary move ment group and 3.6 Gm. in the non-involuntary movement group. Results 1) General comments:Among 121 patients with L-dopa, 29 cases (24%) developed involuntary move ments. 2 patients developed dyskinesia with relatively small doses of 1.5 Gm. daily.

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“…However, in another case, in which a zona incerta lesion on the side opposite to that of sternocleidomastoid contraction was made, the torticollis became worse. In retrospect, we should have made the zona incerta lesion on the side ipsilateral to that of sternocleidomastoid con traction, since our studies [5] showed that stimulation of the zona incer ta region produced discharge contraction of the ipsilateral sternocleido mastoid muscle.…”

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confidence: 94%

Stimulation and Destruction of the Region of the Interstitial Nucleus in Cases of Torticollis and See-Saw Nystagmus

Sano

Sekino

Tsukamoto

et al. 1972

Stereotact Funct Neurosurg

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The interstitial nucleus of Cajal or the adjacent areas including the upper part of the medial longitudinal fasciculus was stimulated and finally destroyed in 12 cases of torticollis (mostly retrocollis) and one case of see-saw nystagmus. Stimulation of the above-mentioned area caused EMG discharges and contraction mostly of the posterior neck muscles in torticollis cases. It reproduced the see-saw nystagmus in one case of posttraumatic see-saw nystagmus. It may be stated that the interstital nucleus and the medial longitudinal fasciculus may play an important regulatory role in neck and eye movements.

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Central Mechanisms of Neck Movements in the Human Brain Stem

Cited by 11 publications

References 0 publications

Stimulation and Destruction of and around the Interstitial Nucleus of Cajal in Man

Stimulation and Destruction of and around the Interstitial Nucleus of Cajal in Man

Stereotactic Thalamotomy and L-dopa Induced Involuntary Movement in Parkinsonism

Stimulation and Destruction of the Region of the Interstitial Nucleus in Cases of Torticollis and See-Saw Nystagmus

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