Central mucoepidermoid carcinoma of the maxilla developing from a calcifying odontogenic cyst: A rare case report

Isshiki-Murakami, Megumi; Tachinami, Hidetake; Tomihara, Kei; Noguchi, Akira; Sekido, Katsuhisa; Imaue, Shuichi; Fujiwara, Kumiko; Imura, Johji; Noguchi, Makoto

doi:10.1002/ccr3.4928

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…Young patients can also experience the transformation of odontogenic cysts into neoplasms, for example, in case report by Isshiki-Murakami et al ., which reported an 18-year-old patient. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Sulistyani,

Iskandar,

Zairinal

et al. 2023

Annals of Maxillofacial Surgery

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Background: Odontogenic cysts have the potential to transform into neoplasms. However, the characteristics of those which transformed to neoplastic tissues have not been well described and the exact causes of that phenomenon are not yet clear. Objectives: This study aims to describe characteristics of odontogenic cysts that transformed into neoplasms and to look for their potential etiologies. Data Sources: English-written studies indexed in PubMed, Science Direct, and Proquest were assessed using keywords verified by Medical Subject Headings: ‘Odontogenic Cyst’ and ‘Neoplastic Cell Transformation’. Study Eligibility Criteria: Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines were used as guidance. Participants: Following steps in PRISMA guidelines, 19 articles were fully reviewed (three case series and 16 case reports) with 27 subjects of 16 males (59%) and 11 females (41%) from 15 to 86 years old. Results: Cystic origins were eight dentigerous cysts, four odontogenic keratocysts, two residual cysts, one radicular cyst, one calcifying odontogenic cyst, one follicular cyst, one glandular odontogenic cyst, and nine unspecified odontogenic cysts that transformed to ameloblastoma (3 cases) and carcinoma (24 cases). Limitations: Neoplastic transformations of odontogenic cysts arose from epithelial remnants of inadequate odontogenic cyst removal and chronic inflammation due to infection. However, the exact causes of their transformations remain unclear. Conclusions: Therefore, careful removal of odontogenic cysts and regular postoperative follow-ups are key to prevent recurrence and neoplastic transformation. Future studies are needed to investigate potential causes of neoplastic transformation of odontogenic cysts.

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Section: Discussionmentioning

confidence: 99%

Transformation of Odontogenic Cysts to Neoplasms - A Systematic Review

Sulistyani,

Iskandar,

Zairinal

et al. 2023

Annals of Maxillofacial Surgery

View full text Add to dashboard Cite

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“…En la literatura revisada no encontramos informe de esta neoplasia en Guatemala. El origen es controvertido, considerándose muchas posibilidades, entre ellas, metaplasia de quistes odontogénicos, atrapamiento de tejidos de glándulas salivales durante el desarrollo embrionario, epitelio del seno maxilar [1,3].…”

Section: Discussionunclassified

“…Se han informado varios factores que pueden estar asociados con el pronóstico, como el sexo, el grado histológico, el abordaje quirúrgico y el estado de los ganglios linfáticos regionales, considerando el tratamiento como un factor pronóstico significativo [2]. El CMEC se caracteriza por recurrencias y metástasis tardías; por lo que se debe realizar seguimiento a largo plazo [2,3]. 10.1186/1477-7819-1-1.…”

Section: Discussionunclassified

“…Esta neoplasia se presenta hasta en un 86% en la glándula parótida, seguido de glándula submandibular y sublingual [1]; representa el 30% de los tumores malignos de glándulas salivales y el 12% de todas las neoplasias de estas glándulas [2]. El CME rara vez ocurre dentro de la mandíbula y se llama CME central (CMEC), representa de 2% a 4% de los CME, puede presentarse también en maxilar, pero con menor frecuencia [1,2,3]. Existe una revisión de la literatura, que informa 133 casos de enero 2,000 hasta julio 2018 [2]; sin embargo, se ha considerado, que por su poca frecuencia e inconsistencia de informes de casos individuales, se dispone de información limitada en relación a su evolución clínica, patogenia, tratamiento y pronóstico [3].…”

Section: Introductionunclassified

“…El CME rara vez ocurre dentro de la mandíbula y se llama CME central (CMEC), representa de 2% a 4% de los CME, puede presentarse también en maxilar, pero con menor frecuencia [1,2,3]. Existe una revisión de la literatura, que informa 133 casos de enero 2,000 hasta julio 2018 [2]; sin embargo, se ha considerado, que por su poca frecuencia e inconsistencia de informes de casos individuales, se dispone de información limitada en relación a su evolución clínica, patogenia, tratamiento y pronóstico [3]. Presentamos el caso de una mujer de 70 años de edad, con diagnóstico de CMEC.…”

Section: Introductionunclassified

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