Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype.

Kaplanski, G.; Rétornaz, F.; Jm, Durand; Soubeyrand, J.

doi:10.1136/jnnp.58.6.758-a

Cited by 29 publications

(11 citation statements)

References 3 publications

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“…The vaccine against yellow fever has been suggested to exacerbate MS [12,13] whereas tetanus vaccine might even have a protective effect on its clinical course [1,7,14]. The HLA-DR2 haplotype has demonstrated linkage and association with susceptibility to multiple sclerosis, especially after hepatitis B vaccination [15,16]. Genetic and epidemiological studies have also picked up populations at risk, such as those with Scandinavian or Scottish ancestry [17].…”

Section: Discussionmentioning

confidence: 99%

Balkans Syndrome: A Potential Link Between Multiple Sclerosis and Hypervaccination

Vacchiano

Vyshka

2012

J R Army Med Corps

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Balkans Syndrome is a recent term that has been widely used in the media to describe a heterogenous group of medical conditions that presented in soldiers following deployment on military operations to the former Yugoslavia and its neighbouring countries. These individuals had been subjected to an intense and protracted course of vaccinations (termed hypervaccination) prior to deployment, which has subsequently been implicated by the media as the cause of this disease. We describe the case of a 33-year old army officer, who received twenty vaccinations and boosters during the period 2000-2006, and was subsequently diagnosed with multiple sclerosis in 2008.

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Section: Discussionmentioning

confidence: 99%

Balkans Syndrome: A Potential Link Between Multiple Sclerosis and Hypervaccination

Vacchiano

Vyshka

2012

J R Army Med Corps

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“…HLA type DR2) has also been suggested. [93,100] In US postmarketing surveillance for neurological events, no significant increased risk among vaccinated persons was detected. [92] A1997 review found no evidence that hepatitis B vaccine causes or exacerbates multiple sclerosis.…”

Section: Other Demyelinating Diseasesmentioning

confidence: 92%

“…[31,[82][83][84][85][86][87][88][89][90][91][92][93][94][95] Several possible explanations for demyelination in hepatitis B disease or following hepatitis B vaccination have been suggested. One implicates the role of immune complexes in inciting an inflammatory demyelination of nervous tissue.…”

Section: Other Demyelinating Diseasesmentioning

confidence: 99%

Safety of Routine Childhood Vaccinations

2000

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Immunisations have been one of the most cost-effective public health interventions in human history. Despite remarkable progress, several challenges face immunisation programs worldwide. Paradoxically, despite vaccines' clear effectiveness in reducing risks of diseases that were previously widely prevalent and caused substantial morbidity and mortality, current vaccination policies have become increasingly controversial due to concerns about vaccine safety. Vaccines, like other pharmaceutical products, are not entirely risk-free. While most known adverse effects are minor and self-limited, some vaccines have been associated with very rare but serious adverse effects. Because such rare effects are often not evident until vaccines come into widespread use, ongoing surveillance programs to monitor vaccine safety are needed. Such monitoring will be essential if the public is to accept the increasing number of new vaccines made possible by biotechnology. The interpretation of data from vaccine safety research is complex and is associated with some uncertainty. Effectively communicating this uncertainty and continuing to improve understanding of rare risks and risk factors are essential for "mature" immunisation programs to maintain public confidence in immunisations.

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“…Granel et al attributed four cases of central retinal vein occlusion in patients under 50 years of age to the vaccine,1 and associations with multiple evanescent white dot syndrome (MEWDS)2 and acute posterior multifocal placoid pigment epitheliopathy (APMPPE)3 have been described. Various related neurological and systemic features of an autoimmune nature have been reported including CNS demyelination 4. Bilateral optic neuritis occurs occasionally in acute hepatitis B infection 5…”

Section: Commentmentioning

confidence: 99%

Simultaneous administration of hepatitis B and polio vaccines associated with bilateral optic neuritis

Stewart

Chang

Bradbury

1999

British Journal of Ophthalmology

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Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype.

Cited by 29 publications

References 3 publications

Balkans Syndrome: A Potential Link Between Multiple Sclerosis and Hypervaccination

Balkans Syndrome: A Potential Link Between Multiple Sclerosis and Hypervaccination

Safety of Routine Childhood Vaccinations

Simultaneous administration of hepatitis B and polio vaccines associated with bilateral optic neuritis

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