Central Nervous System Depressants. I. 1-Aminoalkyl-3-aryl Derivatives of 2-Imidazolidinone,^1a-c 2-Imidazolidinethione, and Tetrahydro-2(1H)-pyrimidinone^1d

Synthesis and characterization of novel chalcone linked imidazolones as potential antimicrobial and antioxidant agents

“…Previously, the imidazolones have been prepared by heating or stirring a mixture of 5-oxazolones derivatives with differently substituted aromatic or aliphatic amines in the presence of excess of pyridine for 10-15 h. The yields of the product were very moderate and the reaction required long time to complete (Siddiqui et al, 2001;Niedbalia and Buettcher, 1981;Pande et al, 1987;Wright et al, 1966;Lingi et al, 1969;Godefroi and Platje, 1972;Verma et al, 1974;Mesaik et al, 2005;Bhalla et al, 1992). In the present work, by the use of zeolite catalyst imidazolones formed at a faster rate in excellent yields.…”

Synthesis and leishmanicidal activity of 2,3,4-substituted-5-imidazolones

“…Previously, the imidazolones were prepared by heating a mixture of 5-oxazolone derivatives with differently substituted aromatic or aliphatic amines in the presence of excess of pyridine for 10-15 h. The yields of the product were moderate and the reaction required a long time to complete [6][7][8][9][10][11][12][13][14][15][16] . In our ongoing research on leishmaniasis [17][18][19][20] , we synthesized 29 imidazolones, 1-29, by treating different oxazolones with varyingly substituted aromatic amines.…”

Synthesis of new imidazolyl acetic acid derivatives with anti-inflammatory and analgesic activities

“…COX-2 inhibitors (Bandararage et al, 2000) have not eliminated the need for improved NSAIDs. Imidazolones have antiinflammatory activity (Pande et al, 1984(Pande et al, , 1987Tuyen et al, 2005;Wright et al, 1966). Here, we made substitutions in known anti-inflammatory agents such as aminoantipyrine, the naproxen salt, and phenylaminoacetic acid to the imidazolone nucleus to obtain compounds with better antiinflammatory activity.…”