Central nervous system effects of the crude extract of Erythrina velutina on rodents

Dantas, Marlon Claudener dos Santos; Oliveira, Fabíola Singaretti; Bandeira, Stephanie Martins Ferreira; Batista, Josemar Sena; Silva, C.D; Alves, Péricles Barreto; Antoniolli, Ângelo Roberto; Marchioro, Murilo

doi:10.1016/j.jep.2004.05.007

Cited by 51 publications

(43 citation statements)

References 11 publications

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“…ex Benth., classified in the Fabaceae family. The first one is a tree measuring from 6 to 10 m and it is very common at the coast region of all north and northeast Brazilian states (Dantas et al, 2004). In the other hand, E. mulungu is a medium-sized well-branched tree native to Southern Brazil (Lorenzi, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Some researches already showed many effects of these species in rodents, like the sedative and neuromuscular blocking actions from the crude extract from the leaves of E. velutina (Dantas et al, 2004), the antinociceptive and the depressant activities of the hydroalcoholic extracts (HAE) from the stem bark of both species (Vasconcelos et al, 2003;2007) and the anxiolytic effect of the HAE from the inflorescence of E. mulungu and from the stem bark of E. velutina (Onusic et al, 2003;Sarragiotto et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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This work studied the anti-inflammatory activities of the hydroalcoholic extracts (HAEs) from Erythrina velutina Willd. (Ev) and E. mulungu Mart. ex Benth. (Em) in the carrageenan-and dextran-induced mice hind paw edema models. These medicinal plants belonging to the Fabaceae family are used in some Brazilian communities to treat pain, inflammation, insomnia and disorders of the central nervous system. In the present work, the extracts were administered orally in male mice at the doses of 200 or 400 mg/kg. In the carrageenan-induced test, only Em showed anti-inflammatory activity, decreasing the paw edema, at the doses of 200 and 400 mg/kg. No effect was observed with Ev in this model. On the other hand, in the dextran model, Ev demonstrated anti-inflammatory effect, showing decrease of the paw edema at the 1, 2, 3, 4 and 24 th h. Em (200 or 400 mg/kg) presented antiinflammatory effect at the 2, 3 and 4 th h after administration of dextran, as compared to control. In conclusion, the work showed that Ev and Em present anti-edematous actions, which possibly occurs by distinct mechanisms. While Ev seems to interfere especially in inflammatory processes in which mast cells have an important role, Em exerts greater activity in the inflammatory process that depends mainly on polymorphonuclear leucocytes. However, further studies are needed to determine the exact mechanism of action of the species investigated.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Vasconcelos¹,

Sales²,

Lima³

et al. 2011

Rev. bras. farmacogn.

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“…São atribuídas às infusões da casca propriedades sudorífica, calmante, emoliente, peitoral e do seu fruto seco ação anestésica local que é usado na forma de cigarro como odontálgico, embora a eficácia e segurança de seu uso ainda não tenham sido confirmadas cientificamente (LORENZI;MATOS, 2002). Dantas et al (2004) evidenciaram que o extrato aquoso das folhas de E. velutina em baixas doses interferiu em processos mnemônicos e, em doses maiores agiu como sedativo e bloqueador neuromuscular periférico. Por sua vez, Virtuoso et al (2005) constataram sua atividade contra o Staphylococcus aureus e Streptococcus pyogenes.…”

Section: Introductionunclassified

Substratos para testes de emergência de plântulas e vigor de sementes de Erythrina velutina Willd., Fabaceae

et al. 2008

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Foram comparados os substratos areia lavada; areia lavada + vermiculita na proporção de 1:1, 3:1 e 1:3; terra vegetal, terra vegetal + areia lavada na proporção de 1:1, 3:1 e 1:3, terra vegetal + vermiculita na proporção de 1:1, 3:1 e 1:3, vermiculita, bioclone®, bioplant® e plugmix®. O delineamento utilizado foi o inteiramente casualizado com 15 tratamentos (substratos) e quatro repetições de 25 sementes. Foram avaliados os seguintes parâmetros: porcentagem de emergência, primeira contagem, índice de velocidade, tempo médio e frequência relativa de emergência, comprimento e massa seca da raiz e parte aérea das plântulas. Constatou-se que os substratos areia e vermiculita foram responsáveis pelos melhores desempenhos, sendo recomendados para condução de testes de emergência de plântulas de mulungu. Palavras-chave: Mulungu, germinação, espécie medicinal AbstractThis research work had as objective to evaluate the effect of different substrates on emergence and seedlings development of Erythrina velutina Willd. The experiment was carried out at the greenhouse of the Laboratory of Vegetable Ecology in the Center of Agrarian Sciences -Federal University of Paraíba. The substrates evaluated were washed sand; washed sand + vermiculite in the proportions of 1:1, 3:1 and 1:3; vegetable earth, vegetable earth + washed sand in the proportions of 1:1, 3:1 and 1:3, vegetable earth + vermiculite in the proportions of 1:1, 3:1 and 1:3, vermiculite, bioclone®, bioplant® and plugmix®. The experimental design was completely randomized with fifteen treatments (substrates) and four replications of 25 seeds. The effect was evaluated through percent of emergence, first count, emergence velocity index, medium time and relative frequency of emergency, length and dry mass of the root and it leaves aerial of the seedling. The substrates sand and vermiculite had the best results and are recommended for conduction of tests of emergency of mulungu seedlings.

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“…Thus, Maity et al (2000) testing the methanol root extract from Ocimum sanctum in the forced swimming test found a signifi cant decrease in the duration of swimming with lower doses (100 and 200 mg/kg) and an increase of this parameter with higher doses (400 mg/kg). In our laboratories, the aqueous and hydroalcaholic extracts from Erythrina velutina leaves showed anxiolytic and amnesic effects at lower doses and inhibition of locomotor activity and prolongation of barbiturate sleeping at higher doses (Dantas et al, 2004). In the apomorphine-induced hypothermia test the H. pectinata AE reversed the effect of apomorphine at the dose of 200 mg/kg.…”

Section: Discussionmentioning

confidence: 82%

Effects of the aqueous extract from Hyptis pectinata leaves on rodent central nervous system

Bueno¹,

Moreira²,

Silva³

et al. 2006

Rev. bras. farmacogn.

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RESUMO: "Efeitos do extrato aquoso das folhas da Hyptis pectinata sobre o sistema nervoso central de roedores". Neste trabalho foram estudados os efeitos do extrato aquoso (EA) obtido das folhas da Hyptis pectinata sobre o sistema nervoso central de roedores. Os seguintes modelos experimentais foram utilizados em camundongos, machos e fêmeas, da linhagem Wistar: "screening" farmacológico, campo aberto, nado forçado, hipotermia induzida por apomorfi na, labirinto em cruz elevado e tempo de sono induzido por tiopental. O extrato foi administrado por via oral em dose única, 30 minutos antes de cada teste. No "screening" farmacológico o EA (400 mg/kg, p.o., n = 3) diminuiu a freqüência do comportamento de auto-limpeza. No teste do campo aberto o EA diminuiu o tempo gasto em auto-limpeza (AE400: 51,3 ± 8,8, q = 5,513, P < 0.01, n = 10) de maneira similar ao diazepam (control: 107,3 ± 14,2; diazepam: 15,4 ± 4,3, q = 9,049, P < 0.001, n = 10). No teste do nado forçado o EA (400 mg/kg) diminuiu o tempo de imobilidade (con: 181,3 ± 7,2 s; imip: 91,6 ± 8,9 s, q = 7,958, P < 0,001; AE400: 111,6 ± 14,5 s, q = 6,193, P < 0,001, n = 9) indicando um possível efeito antidepressivo. Isto foi confi rmado no modelo de hipotermia induzida pela apomorfi na onde o EA (200 mg/kg) antagonizou o efeito da apomorfi na (AE200: -0,27 o C, q = 5,588, P < 0,001, n = 10) de maneira similar à imipramina (5 mg/kg) (control: -1,08 o C; imipramine: 0,02 o C, q = 7,589, P < 0,001, n = 10). Nenhum efeito do EA foi observado nos testes do labirinto em cruz elevado e do tempo de sono induzido por tiopental. Nossos resultados sugerem um possível efeito antidepressivo do extrato aquoso obtido das folhas da Hyptis pectinata. Unitermos:Hyptis pectinata, Lamiaceae, plantas medicinais, depressão. ABSTRACT:The effects of the aqueous extract (AE) from Hyptis pectinata leaves was studied on rodent central nervous system (CNS). Pharmacological screening, open fi eld, forced swimming, apomorphine-induced hypothermia, elevated plus maze and thiopental-induced sleep tests were used in male and female Swiss mice and Wistar rats. The AE was admnistered orally in single doses 30 minutes before each test. In the screening test the AE (400 mg/kg, p.o., n =3) decreased the frequency of grooming behavior. In the open fi eld test it decreased the amount of time rats spent grooming (AE400: 51.3 ± 8.8, q = 5.513, P < 0.01, n = 10), similarly to diazepam (control: 107.3 ± 14.2; diazepam: 15.4 ± 4.3, q = 9.049, P < 0.001, n = 10). In the forced swimming test the AE (400 mg/kg) decreased the immobility time (con: 181.3 ± 7.2 s; imip: 91.6 ± 8.9 s, q = 7.958, P < 0.001; AE400: 111.6 ± 14.5 s, q = 6.193, P < 0.001, n = 9), indicating a possible antidepressive effect. This was confi rmed in the apomorphine-induced hypothermia model where the extract (200 mg/kg) antagonized the apomorphine effect (AE200: -0.27 o C, q = 5.588, P < 0.001, n = 10), similarly to imipramine (imipramine: 5 mg/kg) (control: -1.08 o C; imipramine: 0.02 o C, q = 7.589, P < 0.001, n = 10). No effect of the...

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Central nervous system effects of the crude extract of Erythrina velutina on rodents

Cited by 51 publications

References 11 publications

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice

Substratos para testes de emergência de plântulas e vigor de sementes de Erythrina velutina Willd., Fabaceae

Effects of the aqueous extract from Hyptis pectinata leaves on rodent central nervous system

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