Central nervous system involvement in adult patients with invasive infection caused by Streptococcus agalactiae

Streptococcus agalactiae en adultos no gestantes. Análisis de 10 años en un Hospital Universitario

“…A lo largo de los últimos 25 años ha sido notable el incremento de las infecciones invasivas por S. agalactiae en adultos 11 . Este incremento podría estar relacionado con la mayor esperanza de vida de los adultos mayores con enfermedades crónicas debilitantes 12 , siendo éstas un factor predisponente para adquirir una infección por SGB, en especial en aquellos que padecen DBT o algún tipo de neoplasia 13,14 . Algunos autores sugieren además motivos epidemiológicos y ambientales de transmisión persona-persona o cambios en la distribución de serotipos 9,15 .…”

Neuroimaging in Zoonotic Outbreaks Affecting the Central Nervous System: Are We Fighting the Last War?

“…Invasive group B streptococcus infection is rare in healthy adults, but among patients with chronic underlying comorbidities, 57 it can cause urinary tract and soft-tissue infection, osteomyelitis, infective endocarditis, and pneumonia, but rarely meningitis. 58 In 2015, there was an outbreak of 238 cases of group B streptococcus infections in a foodborne outbreak associated with consumption of Chinese-style raw freshwater fish 59 ; 29 patients had meningoencephalitis, fever, meningism, headache, encephalopathy, focal neurologic deficits, and/or seizures. The invasive serotype III sequence type 283 (ST283) Streptococcus agalactiae was identified as the causative organism, with the same strain identified among farmed freshwater fish used for food preparation.…”

Diffusion-weighted MRI abnormalities in an outbreak ofStreptococcus agalactiaeSerotype III, multilocus sequence type 283 meningitis

“…9 Although there is recent recognition that this organism is a cause of substantial morbidity and mortality among patients with chronic underlying conditions, such as diabetes mellitus, malignancy, neurologic disorders, and skin diseases, [10][11][12] these adults with invasive GBS infection and comorbidities typically suffered from urinary tract and soft tissue infection, osteomyelitis, infective endocarditis and pneumonia; only a minority had meningitis. [13][14][15][16][17][18][19] During the Singapore outbreak of GBS infection, an increased frequency and unusual manifestations were noticed during the prospective surveillance of acute CNS infections by the SNIP investigators and other physicians (T. Barkham and B. Ang, unpublished data). We describe here the clinical, laboratory, and neuroimaging features of a cluster of adults with CNS infections caused by GBS.…”

“…GBS is a common gastrointestinal and genitourinary commensal organism, and although it is an important cause of bacteremia and meningitis in neonates and pregnant women, it seldom causes disease in healthy adults; food‐borne zoonotic GBS infection has not been well‐described in the literature . Although there is recent recognition that this organism is a cause of substantial morbidity and mortality among patients with chronic underlying conditions, such as diabetes mellitus, malignancy, neurologic disorders, and skin diseases, these adults with invasive GBS infection and comorbidities typically suffered from urinary tract and soft tissue infection, osteomyelitis, infective endocarditis and pneumonia; only a minority had meningitis . During the Singapore outbreak of GBS infection, an increased frequency and unusual manifestations were noticed during the prospective surveillance of acute CNS infections by the SNIP investigators and other physicians (T. Barkham and B. Ang, unpublished data).…”