Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Vu, Bien Aimee Nguyen; Duvic, Madeleine

doi:10.1016/j.jaad.2007.09.025

Cited by 20 publications

(30 citation statements)

References 20 publications

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“…This potential for misinterpretation is even more likely for epithelioid glioblastoma because of its tendency to be relatively well-circumscribed and superficially located in the vicinity of the gray-white matter junction. In the present case, the patient's history of mycosis fungoides posed an additional complicating factor as mycosis fungoides involvement of the brain, although rare, is very well recognized 7,18 .…”

Section: Figure 3 Mri T2-flair Image Demonstrating Hyperintense Signmentioning

confidence: 78%

Multifocal epithelioid glioblastoma mimicking cerebral metastasis: case report

et al. 2009

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Objective. Epithelioid glioblastoma is a rare morphologic subtype of glioblastoma that closely mimics metastatic carcinoma or metastatic melanoma histologically. All previous case reports of this unusual glioblastoma variant have been solitary lesions. We report here the first case to our knowledge of multifocal epithelioid glioblastoma mimicking cerebral metastasis.Clinical presentation. A 67-year-old man with a prior history of mycosis fungoides, a common form of cutaneous T-cell lymphoma, presented with memory loss and impaired peripheral vision. Two discrete brain lesions highly suspicious for metastases were identified by magnetic resonance imaging (MRI).Intervention. The patient underwent two separate craniotomies; both lesions were successfully resected in toto with an excellent post-surgical outcome.Conclusion. Epithelioid glioblastoma is one of the rarest morphologic subtypes of glioblastoma. Here we describe the first case to our knowledge of multifocal epithelioid glioblastoma that convincingly mimicked a secondary metastatic process. Multifocal epithelioid glioblastoma should be included in the differential diagnosis of patients who present with multiple discrete brain lesions. An attempt at gross total resection is recommended when anatomically feasible for definitive histopathological diagnosis and to improve progression free survival of patients who present with similarly ambiguous and potentially misleading multiple lesions.

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Section: Figure 3 Mri T2-flair Image Demonstrating Hyperintense Signmentioning

confidence: 78%

Multifocal epithelioid glioblastoma mimicking cerebral metastasis: case report

et al. 2009

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“…Hay apenas 10 casos en la literatura de pacientes con afectación del SNC por MF asociada a TCG 5,7,8 . Los pacientes con MF y TCG tienen una probabilidad del 5% de presentar afectación del SNC, en comparación con el 1,6% de los pacientes sin TCG 8 .…”

Section: Figuraunclassified

“…Los pacientes con MF y TCG tienen una probabilidad del 5% de presentar afectación del SNC, en comparación con el 1,6% de los pacientes sin TCG 8 . Además, mientras los pacientes sin TCG suelen presentar síntomas extracutáneos previos a la afectación cerebral (ganglionar y/o visceral), algunos enfermos con TCG desarrollan las metástasis cerebrales sin haber presentado previamente síntomas extracutáneos, tal y como ocurrió en nuestro caso 8 . En estos pacientes sería recomendable la realización de una TAC cerebral anual 8 .…”

Section: Figuraunclassified

Micosis fungoide con afectación cerebral como primera manifestación extracutánea

Quintana-Sancho

Acebo-Mariñas

Gardeazabal‐García

et al. 2015

Actas Dermo-Sifiliográficas

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“…An autopsy study reported up to 14% of patients with T-cell lymphoma mycosis fungoides (MF) had CNS involvement. However, this is rarely observed in clinical practice, and usually occurs in the setting of large-cell transformation [21]. Likewise, primary cutaneous B-cell lymphoma does not appear to be associated with a high frequency of CNS recurrence [22].…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%