Central nervous system malformation associated with methamphetamine abuse during pregnancy

Maya-Enero, Silvia; Candel-Pau, Júlia; Rebollo-Polo, Mónica; Candela-Cantó, Santiago; Torre, Rafael de la; López-Vílchez, María Ángeles

doi:10.1080/15563650.2018.1428338

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Prenatal MA is teratogenic to animals including rodents and rabbits [74], possibly via an oxidative stress-related pathway [75]. However, definitive teratogenicity between prenatal MA in humans is not established, although there are reports of various abnormalities, including CNS [76], ophthalmic [77] and abdominal wall [78] defects. Again, these studies are confounded by a lack of suitable comparators.…”

Section: Congenital Abnormalitiesmentioning

confidence: 99%

Prenatal methamphetamine—impact on the mother and child—a review

et al. 2021

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Methamphetamine (MA) is the second most commonly used illicit drug in the world, after cannabis. There are limited data on the outcomes of pregnant MA users but there is rapidly emerging evidence to suggest that they are more vulnerable, marginalized and impoverished compared with other drug‐using mothers. MA use during pregnancy is associated with worse pregnancy outcomes and significantly higher rates of co‐existing health and psychosocial problems. Newborn infants exposed to MA are at increased risk of perinatal complications, present differently at birth to infants exposed to other drugs of dependency such as opioids and have poorer neurological adaptation and feeding difficulties. Sparse literature from neuroimaging and cohort studies suggests that the neurocognitive deficits in MA exposed children persist, even into adulthood. Current clinical practice guidelines for the care of substance exposed pregnant women are opioid‐centric with little attention paid to the consequences of prenatal MA exposure.

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Section: Congenital Abnormalitiesmentioning

confidence: 99%

Prenatal methamphetamine—impact on the mother and child—a review

et al. 2021

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“…The number of older pregnant women continues to increase with the implementation of the two-child policy in China. In addition, due to the effects of radiation, drugs, chemical reagents, chromosome variation, heredity, environmental pollution, dietary structure changes, and many other factors, the incidence of fetal malformations continues to increase[ 8 , 9 ]. CNS malformations, such as the vein of Galen malformation and exposed brain malformation, are a common group of fetal malformations.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of ultrasonography in diagnosis of fetal central nervous system malformation

Pang

Pan

et al. 2021

WJCC

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BACKGROUND Prenatal examination is an important measure for the screening and diagnosis of fetal malformations. AIM To investigate the accuracy of ultrasonography in the diagnosis of fetal central nervous system (CNS) malformations. METHODS One hundred and thirteen pregnant women suspected of having fetal CNS malformations were examined at our hospital from December 2018 to October 2020 using two-dimensional ultrasonography and three-dimensional ultrasonography, respectively. RESULTS According to the pathological results, there were 79 cases of CNS malformations and 34 cases of non-CNS malformations among the 113 pregnant women suspected of having fetal CNS malformation. Fifty-one cases of CNS malformation and 26 cases of non-CNS malformation were detected by two-dimensional ultrasonography, and 73 cases of CNS malformation and 30 cases of non-CNS malformation were detected by three-dimensional ultrasonography. The diagnostic sensitivity (92.41%) and accuracy (91.15%) of three-dimensional ultrasonography were higher than those of two-dimensional ultrasonography (64.56% and 68.14%, respectively) ( P = 0.000). The specificity of three-dimensional ultrasonography (88.24%) was higher than that of two-dimensional ultrasonography (76.47%); however, the difference was not significant ( P = 0.203). CONCLUSION Three-dimensional ultrasonography has high application value in the diagnosis of fetal CNS malformations. In addition, the image quality is clear, and the diagnostic sensitivity and accuracy are high.

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“…Thus prenatal METH exposure may affect maternal health and also increase the risk of pregnancy complications like hypertension and preeclampsia during pregnancy as well as cause short-or long-term damage to the fetus. Silvia reported a case of neonatal brain malformation due to prenatal METH abuse in Philippines, and METH was detected in the urine of the mother and the newborn (Maya-Enero et al, 2018). Eugeni also reported a similar case, in which a full-term newborn born suffered seizures and severe neurological symptoms shortly after birth due to prenatal METH exposure, followed by severe liver insufficiency (Maranella et al, 2019).…”

Section: Introductionmentioning

confidence: 95%

The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review

Liu

Zhang

et al. 2021

Front. Pharmacol.

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Abuse of methamphetamine (METH), an illicit psychostimulant, is a growing public health issue. METH abuse during pregnancy is on the rise due to its stimulant, anorectic, and hallucinogenic properties. METH can lead to multiple organ toxicity in adults, including neurotoxicity, cardiovascular toxicity, and hepatotoxicity. It can also cross the placental barrier and have long-lasting effects on the fetus. This review summarizes neurotoxicity, cardiovascular toxicity, hepatotoxicity, toxicity in other organs, and biomonitoring of prenatal METH exposure, as well as the possible emergence of sensitization associated with METH. We proposed the importance of gut microbiota in studying prenatal METH exposure. There is rising evidence of the adverse effects of METH exposure during pregnancy, which are of significant concern.

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Central nervous system malformation associated with methamphetamine abuse during pregnancy

Abstract: The aim of our report is to generate awareness of the possible association between methamphetamine abuse during pregnancy and central nervous system malformations.

Cited by 7 publications

References 11 publications

Prenatal methamphetamine—impact on the mother and child—a review

Prenatal methamphetamine—impact on the mother and child—a review

Accuracy of ultrasonography in diagnosis of fetal central nervous system malformation

The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review

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