Central nervous system neurotensin and feeding

Hawkins, Mike F.

doi:10.1016/0031-9384(86)90064-8

Cited by 63 publications

(24 citation statements)

References 38 publications

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“…It may be argued that in the present experiment, the NT analog did not induce reinstatement of sucrose seeking because it, instead, induced an anorectic effect that inhibited behavior directed toward obtaining sucrose. Central injections of NT have in fact been found to decrease food consumption in food-deprived rats, within the dose range that we tested in the present study (Hawkins 1985;Luttinger et al 1982). The significance of these findings to the interpretation of our results, however, is not clear, given that our animals were not food-deprived at the time of testing.…”

Section: Discussioncontrasting

confidence: 72%

Activation of central neurotensin receptors reinstates cocaine seeking in the rat: modulation by a D1/D5, but not D2/D3, receptor antagonist

Lopak

Erb

2005

Psychopharmacology

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Section: Discussioncontrasting

confidence: 72%

Activation of central neurotensin receptors reinstates cocaine seeking in the rat: modulation by a D1/D5, but not D2/D3, receptor antagonist

Lopak

Erb

2005

Psychopharmacology

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“…We also found that the CARTand NT-positive neurons in the DMH comprise distinct populations, indicating that leptin activates different peptidergic systems within the DMH. Interestingly, both CART and NT decrease feeding when injected i.c.v., but the exact anatomic substrate underlying these effects is not well understood (Luttinger et al, 1982;Hawkins, 1986;Lambert et al, 1997Lambert et al, , 1998Kristensen et al, 1998).…”

Section: Hypothalamic Cart Neurons Are Engaged By Leptinmentioning

confidence: 97%

Characterization of CART neurons in the rat and human hypothalamus

Elias

Lee

Kelly

et al. 2001

J of Comparative Neurology

378

254

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Cocaine- and amphetamine-regulated transcript (CART) is a recently described neuropeptide widely expressed in the rat brain. CART mRNA and peptides are found in hypothalamic sites such as the paraventricular nucleus (PVH), the supraoptic nucleus (SON), the lateral hypothalamic area (LHA), the dorsomedial nucleus of the hypothalamus (DMH), the arcuate nucleus (Arc), the periventricular nucleus (Pe), and the ventral premammillary nucleus (PMV). Intracerebroventricular administration of recombinant CART peptide decreases food intake and CART mRNA levels in the Arc are regulated by leptin. Leptin administration induces Fos expression in hypothalamic CART neurons in the PVH, the DMH, the Arc, and the PMV. In the current study, we used double label in situ hybridization histochemistry to investigate the potential direct action of leptin on hypothalamic CART neurons and to define the chemical identity of the hypothalamic CART neurons in the rat brain. We found that CART neurons in the Arc, DMH, and PMV express long form leptin-receptor mRNA, and the suppressor of cytokine signaling-3 (SOCS-3) mRNA after an acute dose of intravenous leptin. We also found that CART neurons in the parvicellular PVH, in the DMH and in the posterior Pe coexpress thyrotropin-releasing hormone (TRH) mRNA. CART neurons in the magnocellular PVH and in the SON coexpress dynorphin (DYN), and CART cell bodies in the LHA and in the posterior Pe coexpress melanin-concentrating hormone (MCH) and glutamic acid decarboxylase (GAD-67) mRNA. In the Arc, a few CART neurons coexpress neurotensin (NT) mRNA. In addition, we examined the distribution of CART immunoreactivity in the human hypothalamus. We found CART cell bodies in the PVH, in the SON, in the LHA, in the Arc (infundibular nucleus) and in the DMH. We also observed CART fibers throughout the hypothalamus, in the bed nucleus of the stria terminalis, and in the amygdala. Our results indicate that leptin directly acts on CART neurons in distinct nuclei of the rat hypothalamus. Furthermore, hypothalamic CART neurons coexpress neuropeptides involved in energy homeostasis, including MCH, TRH, DYN, and NT. The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans.

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“…The neuropeptide neurotensin (Nts) acts centrally to suppress feeding in hungry and obese rodents, and holds potential to counteract increased appetitive drive that thwarts sustained weight loss (Boules et al, 2000; Cooke et al, 2009; Feifel et al, 2010; Hawkins, 1986b; Kim et al, 2008; Luttinger et al, 1982). Nts can signal via the G-protein-coupled Nts receptors−1 and −2 (NtsR1 and NtsR2) and NtsR1 has been specifically implicated in mediating anorectic effects (Kim et al, 2008; Remaury et al, 2002).…”

mentioning

confidence: 99%

Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms

et al. 2017

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SUMMARY The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguingly, these dual weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the LHA Nts circuit, but not for regulation of locomotor or drinking behavior. Furthermore, although LHA Nts neurons cannot reduce intake of freely available obesogenic foods, they effectively restrain motivated feeding in hungry, weight-restricted animals. LHA Nts neurons are thus vital mediators of central Nts action, particularly in the face of negative energy balance. Enhanced action via LHA Nts neurons may therefore be useful to suppress the increased appetitive drive that occurs after lifestyle-mediated weight loss, and hence to prevent weight regain.

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Central nervous system neurotensin and feeding

Cited by 63 publications

References 38 publications

Activation of central neurotensin receptors reinstates cocaine seeking in the rat: modulation by a D1/D5, but not D2/D3, receptor antagonist

Activation of central neurotensin receptors reinstates cocaine seeking in the rat: modulation by a D1/D5, but not D2/D3, receptor antagonist

Characterization of CART neurons in the rat and human hypothalamus

Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms

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