Central nervous system processing of emotions in children with nocturnal enuresis and attention‐deficit/hyperactivity disorder

Equit, Monika; Becker, A.; Khatib, Diana El; Rubly, M.; Becker, Nicolas; Gontard, Alexander von

doi:10.1111/apa.12676

Cited by 22 publications

(15 citation statements)

References 28 publications

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“…Children with functional gastrointestinal disorders are more susceptible to developing emotional and behavioral symptoms, and electrophysiological studies have shown that children with fecal incontinence have increased responses in the processing of emotions; this suggests neurobiological vulnerability and could possibly be due to “cross‐talk” between the ENS and CNS. The responses are even more pronounced than in children with enuresis …”

Section: Other Factorsmentioning

confidence: 88%

“…The responses are even more pronounced than in children with enuresis. 76 The role for the gut microbiome in sensitization is speculative as it has been postulated that bidirectional communication between the microbiome and brain plays a role in depression and bowel symptoms. 77 Bacteriuria is associated with a range of LUT symptoms, and the role of a putative bladder microbiome in the sensitization of spinal neurons needs to be further explored.…”

Section: Other Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

Panicker

Marcelissen

Gontard

et al. 2019

Neurourology and Urodynamics

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Aims: Mounting evidence from experimental animal and human studies suggests that cross-sensitization exists between different organs. Lower urinary tract (LUT) and bowel dysfunction commonly overlap, and the role of crosssensitization between pelvic visceral organs is uncertain. Methods: At the International Consultation on Incontinence Research Society (ICI-RS) meeting in 2018, a panel of clinicians participated in a discussion on bladder and bowel interactions in the context of pelvic organ cross-sensitization.Results: Bladder and bowel problems commonly co-occur in adults and children across different disorders, and the mechanism responsible for overlapping dysfunction is uncertain in most instances. At a neuronal level, cross-sensitization occurs as a result of afferent signaling from the LUT and lower bowel through different central and peripheral mechanisms. Studies in animals and humans have demonstrated evidence for cross-organ sensitization following experimental inflammation or distension of the lower bowel, affecting the LUT. Nerve stimulation is an effective treatment for different functional LUT and bowel disorders, and whether this treatment may influence crossorgan sensitization remains uncertain. The role of physiologically dormant C-fibers, the bladder-gut-brain axis, and gut microbiome in cross-sensitization are speculative. Conclusion: Recommendations for research were made to explore the role of cross-organ sensitization in the pathogenesis of co-occurring LUT and bowel dysfunction in humans. K E Y W O R D Sbladder pain syndrome, constipation, cross-organ, cross-talk, irritable bowel syndrome, microbiome, psychology, sensitization F I G U R E 1 Inter-relationship between disorders of the lower urinary tract and bowel. LUTS, lower urinary tract symptoms S26 |

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Section: Other Factorsmentioning

confidence: 88%

Section: Other Factorsmentioning

confidence: 99%

Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

Panicker

Marcelissen

Gontard

et al. 2019

Neurourology and Urodynamics

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“…For example, one study found that parental sensitivity in early childhood is positively associated with markers of more optimal brain development at age 8, and suggested that stimulation provided by sensitive caregivers can facilitate increases in brain volume and cortical thickness 39 . Thus, parenting may contribute to the maturational deficits of the central nervous system that have been postulated to underlie the development of enuresis 5,40 . This also raises the intriguing possibility that interventions that promote authoritative parenting may reduce children’s risk of developing enuresis and possibly even the psychopathology that is subsequently associated with enuresis.…”

Section: Discussionmentioning

confidence: 99%

“…However, our results also indicate that functional impairment is evident in these youth even before they are eligible for a diagnosis of enuresis, and that later observations of impairment reflect earlier difficulty in functioning. Indeed, evidence suggests that enuretic children are likely to have executive functioning problems 40 , which could impact their daily living. In contrast, after accounting for preexisting impairment, primary enuresis does not appear to have an additional long-term impact on functioning.…”

Section: Discussionmentioning

confidence: 99%

Predictors and Outcomes of Childhood Primary Enuresis

Kessel

Allmann

Goldstein

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

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Objective Although enuresis is relatively common in early childhood, research exploring its antecedents and implications is surprisingly limited, perhaps because the condition typically remits in middle childhood. Method We examined the prevalence, predictors, prognostic factors, and outcomes of primary enuresis in a large (N = 559) multi-method, multi-informant prospective study with a community-based sample of children followed from age 3 to age 9. Results We found that 12.7% of our sample met criteria for lifetime enuresis, suggesting that it is a commonly occurring childhood disorder. Males were over twice as likely to have a lifetime diagnosis than females. Significant age 3 predictors of developing primary enuresis at age 9 included child anxiety and low positive affectivity, maternal history of anxiety, and low authoritative parenting. In addition, poorer global functioning and more depressive and anxiety symptoms at age 3 predicted a greater likelihood of persistence through age 9. By age 9, 77% of children who had received a diagnosis of primary enuresis were in remission and continent. However, children who had remitted exhibited a higher rate of ADHD and greater ADHD and depressive symptoms at age 9 compared to children with no lifetime history of enuresis. Conclusions Results of the present study underscore the clinical significance of primary enuresis and demonstrate that it shows both strong antecedent and prospective associations with psychopathology. The findings also highlight the possible role of parenting in the development of enuresis.

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“…Children with MNE showed more intense responses than controls, whereas those with ADHD did not differ from the controls. Children with MNE + ADHD elicited the strongest responses [109]. They concluded that children with MNE process emotions differently from children with ADHD and controls.…”

Section: Psychological Disordersmentioning

confidence: 96%

Pediatric Bladder Disorders

Bérard

2014

Pediatric Nephrology

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Central nervous system processing of emotions in children with nocturnal enuresis and attention‐deficit/hyperactivity disorder

Abstract: Children with NE processed emotions differently from children with ADHD and controls. Children with NE + ADHD processed emotions the most intense, displaying interaction effects of the central nervous system that cannot be explained by each disorder alone.

Cited by 22 publications

References 28 publications

Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

Bladder‐bowel interactions: Do we understand pelvic organ cross‐sensitization? International Consultation on Incontinence Research Society (ICI‐RS) 2018

Predictors and Outcomes of Childhood Primary Enuresis

Pediatric Bladder Disorders

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