Central nervous system side-effects of 5-HT3-receptor antagonists in elderly cancer patients treated with chemotherapy

Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists

“…The obtained solids were washed with water (2 × 100 mL) and dried under vacuum oven overnight. The target product was obtained in a 45% yield, mp: 180-184°C (Lit 181-184°C); 1 …”

“…The solids were acidified with concentrated hydrochloric acid; the obtained off-white solids were filtered, washed with water and dried in a vacuum oven overnight. The desired acid was obtained in 50% yield, mp: 210-212°C (Lit 209-210°C); 1 General procedure for the synthesis of quinoxaline-2-carboxamides(4a-p and 5a-5d)…”

“…Nausea and vomiting are the most common adverse effects of the existing chemotherapeutic agents and these side-effects occur in a substantial number of patients whose undergoing surgery or radiation therapy [1][2][3][4] . Although nausea and vomiting seems like harmless sideeffects, inadequately controlled emesis can result in serious dehydration, loss of sodium and other electrolytes, nutritional depletion and loss of appetite, weight loss, oesophageal tears, deterioration of patient's physical, and mental status (anxiety and depression) which prompt them into non-adherence to the life saving anticancer treatment [5][6] .…”

Ligand‐Based Design, Synthesis, and Pharmacological Evaluation of 3‐Methoxyquinoxalin‐2‐carboxamides as Structurally Novel Serotonin Type‐3 Receptor Antagonists

“…Antagonists of this 5‐HT 3 receptor displayed anti‐emetic action in cancer chemo‐/radiotherapy induced nausea and vomiting. Nausea and vomiting are the most common adverse effects of the existing chemotherapeutic agents and these side‐effects occur in a substantial number of patients who are undergoing surgery or radiation therapy 5–8. The clinically existing 5‐HT 3 receptor antagonists substantially increase the patient compliance for anti‐cancer treatment 7 by decreasing their side‐effects (nausea and vomiting), but unfortunately these antagonists are ineffective in 10–30% of patients 9, 10.…”

Screening of Methanol Extract and Ethyl Acetate Fraction of Abies webbiana Lindl. for Neuropharmacological Activities

“…About 14% of the global burden of disease has been attributed to mental disorders [4] . Although synthetic drugs are easily available in market for the treatment of mental disorders but these drugs are associated with severe side effects such as memory impairment, addiction and dependence [5] , sexual dysfunction [6] , headaches, dizziness and abnormal vision [7] . Researchers are exploring natural resources to find out newer, efficacious and safer drugs.…”