2000
DOI: 10.1046/j.1365-2826.2000.00560.x
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Central Nervous System Structures Labelled from the Testis Using the Transsynaptic Viral Tracing Technique

Abstract: In the present study, the transneuronal transport of neurotrophic virus technique was used to identify cell groups of the spinal cord and the brain that are transsynaptically connected with the testis. Pseudorabies virus was injected into the testis and after survival times of 3-6 days, the spinal cord and brain were processed immunocytochemically using a polyclonal antibody against the virus. Virus-infected perikarya were detected in the preganglionic neurones of the spinal cord (T10-L1, L5-S1) and in certain… Show more

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Cited by 57 publications
(38 citation statements)
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“…To the best of our knowledge, this is perhaps the first piece of such an information. Since there is a high density of AII receptors in the LC, the observation of the present study indicates that AII receptors that modulated the LC-testis axis through a multisynaptic circuit of neurons [12] may have started to influence testicular function long before 4 weeks of age. Furthermore, at the 9-week and 16-week hypertensive stages, TW remains heavier in SHR rats than in WKY rats.…”
Section: Discussionmentioning
confidence: 57%
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“…To the best of our knowledge, this is perhaps the first piece of such an information. Since there is a high density of AII receptors in the LC, the observation of the present study indicates that AII receptors that modulated the LC-testis axis through a multisynaptic circuit of neurons [12] may have started to influence testicular function long before 4 weeks of age. Furthermore, at the 9-week and 16-week hypertensive stages, TW remains heavier in SHR rats than in WKY rats.…”
Section: Discussionmentioning
confidence: 57%
“…As to the organ function, the recent literature also shows that there is an LC-testis axis [12] in addition to the traditional hypothalamic-pituitary control of the testis [24]. Furthermore, a functional relationship seems to exist between the testicular testosterone production and the state of hypertension in SHR rats [15].…”
Section: Introductionmentioning
confidence: 99%
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“…For complete protection by IC immunization, other blocking mechanisms may be involved. Using antibodies against the PRV, infected neurons in the spinal cord and brain were identified by means of immunocytochemistry after injection of PRV into an end-organ, testis (17). From the infected terminals, the virus travels along the axon to the perikaryon where it replicates and then infects transsynaptically neural elements in synaptic contact with the infected perikaryon.…”
Section: Discussionmentioning
confidence: 99%
“…There is growing evidence that brain areas, such as the caudal raphe nuclei, locus coeruleus, periaqueductal grey matter, are transneuronally connected with the gonads (Gerendai et al, 2000a;Gerendai et al, 2000b) and their involvement in a complementary control mechanism independent of the pituitary gland has been suggested. The role of this neural influence in the control of gonadal functions is consistently shown by studies based on transections or lesions in the peripheral or central nervous system (Gerendai et al, 1997;Banczerowski et al, 2001) and by recent observations showing an inhibitory effect of the right occipital cortex on tes-ticular steroidogenesis (Lepore et al, 2006).…”
mentioning
confidence: 99%