Central Nervous System Tuberculosis

Soleiman-Meigooni, Saeed

doi:10.1016/b978-0-12-813806-9.00009-3

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2023

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Cited by 2 publications

References 27 publications

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Clinical presentation of pulmonary and extrapulmonary tuberculosis

Akkerman,

Guenther,

Munoz-Torrico

et al. 2023

The Challenge of Tuberculosis in the 21st Century

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Clinical presentation of pulmonary and extrapulmonary tuberculosis

Akkerman,

Guenther,

Munoz-Torrico

et al. 2023

The Challenge of Tuberculosis in the 21st Century

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Role of IL 6 as a Biomarker in the Diagnosis of Tuberculous Meningitis – A Systematic Review

Kruthika

2022

The International Journal of Mycobacteriology

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Background: Tuberculous meningitis (TBM) is the most common and serious form of central nervous system tuberculosis (TB) with high morbidity and mortality. Following the encounter of tubercle bacilli by microglial cells, inflammatory process sets in and series of cytokines are secreted such as tumor necrosis factor, interleukin-6 (IL6), and interferon γ. The following study was undertaken with the aim of systemically reviewing the diagnostic and prognostic evidence of IL6 in TBM. Methods: After a thorough search of databases for the articles with IL6 association in TBM published from 2001 onwards to September 2021. Articles were identified and assessed according to the inclusion and exclusion criteria. Excel spreadsheets were used for the extraction of data and analysis. Results: A total of 10 studies were included for review which focused on IL6 in the role of TBM diagnosis. All the age group persons of both sexes were included in the study. The experiment was conducted mostly in the developing countries. The range of measured IL6 values was very wide and difficult to interpret. Conclusion: TBM patients' IL 6 was higher than healthy controls in all the studies mentioned, but the results of cerebrospinal fluid IL6 and serum IL6 were less consistent. Due to a small number of prospective studies, it was not possible to analyze the IL6 cut-off value to diagnose TB. Further studies are required to provide information on IL6 as biomarker in the diagnosis of TBM.

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Central Nervous System Tuberculosis

Cited by 2 publications

References 27 publications

Clinical presentation of pulmonary and extrapulmonary tuberculosis

Clinical presentation of pulmonary and extrapulmonary tuberculosis

Role of IL 6 as a Biomarker in the Diagnosis of Tuberculous Meningitis – A Systematic Review

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