Central nervous system tumours profile at a referral center in the Brazilian Amazon region, 1997–2014

Abstract

Tumours of the Central Nervous System (CNS) are an important cause of mortality from cancer. Epidemiological data on neoplams affecting the CNS are scarce in Brazil, especially in the Amazon region. The study aims at describing the histopathological profile of CNS tumours cases at a high-complexity referral cancer center. This study has described a 17-year-series profile of CNS tumours, registered at a high-complexity referral cancer center in Pará state, from January 1997 until July 2014 in the Brazilian Amazon Region. Data was gathered from histopathology reports kept in the hospital’s cancer registry and 949 cases of CNS tumours were analyzed. The most common histopathology were neuroepithelial tumours (approx. 40%) and meningioma was the most frequent especific tumor histologic subtype (22.2%). Neuroepithelial tumours were more frequent in patients with ages ranging from less than a year to 19 years, whereas metastatic tumours were prevalent in patients over 40 years of age. It was not found temporal trends during the studied period. The knowledge of these tumours profile is valuable for the understanding of cancer epidemiology in the region, since its prevalence is currently underreported and more awareness on the disease is needed.

Demographics and Incidence of Histologically Confirmed Intracranial Tumors: A Five-year, Two-center Prospective Study

“…However, based on the time gap, these differences could be attributed to advances in neurosurgery and its increased availability for the global population. On the other hand, our results are very close in figures to those reported by Werneck de Carvalho, et al in Brazil in 2017, despite some variances in study design and populational differences [ 27 ]. Nonetheless, the results of all studies concur with ours, stating that primary ICTs are greater in incidence when compared to metastatic ICTs, despite the values ranging from 1.6% to 49% for metastatic ICTs, when compared to our results stating 30.90%.…”

“…Although favoring the classification of primary ICTs and NVOLs when compared to metastatic ICTs, due to the histological verification criteria, our study reports similar findings to other studies [ 2 , 20 , 24 , 26 - 28 ]. Our findings concur with the total incidence for primary ICTs when compared to similar modern analyses on the topic, giving nearly identical rates for the most commonly diagnosed lesions [ 2 , 27 ].…”

“…Similar studies to ours are rarely undertaken [ 27 ]. Our results, to our knowledge, are the only ones giving modern insight in such depth to the problem and the first ever to touch on it in our population.…”

A Comparative Review of Demographics, Incidence, and Epidemiology of Histologically Confirmed Intracranial Tumors in Brazil and Bulgaria

“…The data was compared on the merit of major histopathological groups to accommodate the differences in the 2006 and 2016 World Health Organization (WHO) classification of tumors of the CNS intracranial tumors used in the two separate studies (Table 1 ) [ 6 , 33 - 35 ]. Metastatic tumors were considered those not arising from the cranial cavity and the structures inside it, including infiltrative tumors such as lymphomas and leukemias.…”

“…The aim of this review is to discuss our experiences and compare the findings regarding ICTs in our distinct populations, based on our data from Brazil, published by de Carvalho, et al spanning across 17 years and 949 cases and from Bulgaria, published by Stoyanov, et al spanning across five years and 798 cases [ 33 - 34 ].…”