Central neurocytoma without intraventricular extension

Sgouros, Spiros; Jackowski, A.; Carey, Martyn

doi:10.1016/0090-3019(94)90405-7

Cited by 49 publications

(22 citation statements)

References 12 publications

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“…Extension into the third ventricle occurs in 26% of central neurocytomas. Isolated third or fourth ventricular occurrence and extraventricular sites are rarely reported [9][10][11][12][13][14]. There are also rare cases of central neurocytomas with craniospinal dissemination [15].…”

Section: Radiologymentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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Purpose-Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus. Typically, it has a favorable prognosis after adequate surgical intervention, but in some cases the clinical course is more aggressive. In this report, we describe the diagnosis and treatment of central neurocytoma in a series of patients at our institution.Patients and Methods-Our series of nine patients (M:F=2:7, mean age, 28.2 years) with ventricular tumors showed typical radiological, histologic and immunohistochemical features of central neurocytoma. Most patients received craniotomy with removal of the tumor through transcallosal or transcortical approach. The surgical and histopathologic data of these patients were reviewed and analyzed.Results-The prognosis is generally favorable. Although most patients were alive and well at the last follow-up, two developed recurrence. Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. Two patients (non-recurrent) died during follow-up due to sepsis or central failure. The MIB-1 labeling indices were as high as 2.2-5.4% for these two patients.Conclusion-Although central neurocytoma is generally a benign neoplasm, some variant forms of recurrence are also present. Complete resection provides favorable long-term prognosis in most cases. Recurrent tumors are often local and the patients seem to recover well after a second resection followed by radiotherapy. Histologic features such as tumor proliferation (MIB-1 labeling index), vascular proliferation, and synaptophysin expression are often prominent in the recurrent tumor. We recommend that these histologic features be considered for tumor recurrence during treatment and follow-up of these patients.

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Section: Radiologymentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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“…The neurocytoma cells have been hypothesized to arise from remnants of subependymal plate or from the gray matter of the septum pellucidum and lateral ventricle, thus explaining their preferential localization. Some extraventricular locations recently reported include the occipital lobe, 14 parietal, temporal and frontal lobes, 15 hypothalamus, 15 cerebellum, 16 pons, 17 spinal cord, 18 cauda equina, 19 as part of a mature cystic teratoma of the ovary 20 and even in the retina. 21 As is the case with all central nervous system tumors, location of the lesion and imaging characteristics are of paramount importance in helping the pathologist make a correct diagnosis.…”

Section: Discussionmentioning

confidence: 98%

Clinical Ophthalmic Presentations of Central Neurocytoma

Sée

Yang

Loh

et al. 2006

Neuro-Ophthalmology

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Central neurocytoma is a rare tumor of the central nervous system occurring in young adults, typically located in the lateral ventricles and around the foramen of Monro. The neoplasm is composed of uniform round cells with neuronal differentiation and is associated with a varied biologic behavior. We report 2 cases of central neurocytomas presenting to the ophthalmologist as chronic progressive blurring of vision. The available literature on the presentation, pathology, and treatment of central neurocytomas is also reviewed.

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“…Rarely, such tumors have been described in extraventricular sites. 1,[5][6][7][8][9]12,13,[15][16][17][18]20,22,25 We report the case of a low-grade neurocytoma arising primarily in the brainstem and involving the cerebel-lum, with spread along the CSF pathways to the lateral and third ventricles. A neurocytoma presenting with disease in all of these locations simultaneously has not been previously reported.…”

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confidence: 99%

Infiltrative brainstem and cerebellar neurocytoma

Ahmad

Rosenblum

Chamyan

et al. 2012

PED

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Neurocytomas are typically intraventricular in location, and extraventricular neurocytomas are uncommon. The authors report the unique case of a 15-year-old girl who was found to have a low-grade neurocytoma infiltrating the brainstem and cerebellum and spreading along the CSF pathways to the lateral and third ventricles. The patient underwent endoscopic third ventriculostomy to treat associated hydrocephalus, and biopsy specimens from intraventricular tumor nodules were obtained. Because of the low-grade pathology, the fact that the lesion was not amenable to resection, and the extensive radiation field required for radiation therapy, she has been treated conservatively with close follow-up. Over the course of almost 4 years since diagnosis, no additional treatment has been required. Neurocytoma with widespread infiltration of the brainstem and cerebellum has not been previously reported.

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Central neurocytoma without intraventricular extension

Cited by 49 publications

References 12 publications

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Clinical Ophthalmic Presentations of Central Neurocytoma

Infiltrative brainstem and cerebellar neurocytoma

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