Central neurocytoma

Hassoun, Jacques; Gambarelli, D.; Grisoli, F; Pellet, W; Salamon, G; Pellissier, J. F.; Toga, M

doi:10.1007/bf00690587

Cited by 488 publications

(96 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our case the neurocytoma was in an unusual location and caused spinal seeding (although we do not have pathological confirmation for the spinal lesions), but histopathologically, no mitosis or necrosis was seen and also the MIB-1 labeling index was less than 1 .…”

Section: Discussionmentioning

confidence: 60%

“…Neurocytoma was first described by Hassoun et al, in 1982 as a well-differentiated neuronal tumor 1 . He described a neuronal tumor with pathological features distinct from cerebral neuroblastomas, occurring in lateral and third ventricles, and histologically mimicking oligodendrogliomas.…”

Section: Discussionmentioning

confidence: 99%

“…Neurocytoma is described as a well-differentiated tumor of neuronal origin and it is distinct from ganglion cell tumors and neuroblastoma 1 . The cells remain rare neoplasms of the central nervous system, accounting for only 0.25-0.5% of all brain tumors 2 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

Şeker¹,

Tanrıkulu²,

Yener³

et al. 2011

MMJ

View full text Add to dashboard Cite

Central neurocytomas are typically located in lateral or third ventricles. Here, we report a case of neurocytoma located in the middle cerebellar peduncle. A 36-year-old male patient presented with symptoms of ataxic gait and urinary incontinence for one month. Magnetic resonance imaging (MRI) of the brain revealed a slightly enhanced lesion on the left middle cerebellar peduncle with obstructive hydrocephalus. The preoperative diagnosis was a glial tumor and a subtotal surgical removal was performed. Following pathological studies, the final definitive diagnosis was made as central neurocytoma. Six months after surgery, the patient presented with low back pain and bilateral lower extremity weakness. Lumbar MRI studies revealed multiple intradural-extramedulary lesions. The patient was not operated for spinal lesions. He was treated with palliative radiotherapy in the metastatic spinal area. Cerebellar peduncle is an atypical location for a neurocytoma. Neurocytomas in atypical locations may behave more aggressively and make spinal seeding. According to neuroradiological and clinical presentation, these tumors may have been confused with other common cerebellar lesions. Pathological examination is needed for definitive diagnosis. Favorable prognosis is related to total tumor excision.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

Şeker¹,

Tanrıkulu²,

Yener³

et al. 2011

MMJ

View full text Add to dashboard Cite

show abstract

“…Based on these morphological features, the present case was diagnosed as oligodendroglioma. Recently, it has been reported that some brain tumors including astrocytoma, ependymoma, or central neuroma, can occasionally exhibit honeycomb-like structures [3,7]. However, the negative immunoreactivity of the tumor for GFAP, NSE, NF and synaptophysin may support our diagnosis.…”

mentioning

confidence: 69%

Spinal Oligodendroglioma with Diffuse Arachnoidal Dissemination in a Japanese Black Heifer.

Uchida

Muranaka

Murakami

et al. 1999

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. A gelatinous focus with cystic spaces, was found in the posterior funiculus of the 2nd to 3rd lumbar levels of the spinal cord of a Japanese Black heifer, 2 years old, with clinical signs of severe dysstasia. Histopathological examination revealed that the spinal lesion consisted of multifocal and diffuse proliferation of round cells with abundant vacuolar cytoplasm and hyperchromatic nuclei. In the lesions there was a number of cystic spaces containing aggregates of small round cells. The neoplastic foci showed a honeycomb structure divided by thin blood vessels, representing typical lesions of oligodendroglioma. Diffuse and multifocal proliferation of these round cells were also recognized in the subarachnoidal space in the sacral spinal cord. Immunohistochemically, the proliferating round cells were negative for glial fibrillary acidic protein. Based on these morphological features, the case was diagnosed as lumbar spinal oligodendroglioma with diffuse arachnoidal dissemination.-KEY WORDS: bovine, oligodendroglioma, spinal cord.J. Vet. Med. Sci. 61(12): 1323-1326, 1999 cord were also stained with Luxol fast blue (LFB), Masson's trichrome, Watanabe's silver impregnation, and alcian blue (pH 2.5). Histopathological examination revealed that the lumbar spinal lesion consisted of multifocal and diffuse proliferation of neoplastic cells with cystic spaces (Fig. 2). The tumor mass was located mainly in the white matter, and the posterior funiculus were almost totally replaced by the proliferating tumor cells and cystic places. The neoplastic foci showed a honeycomb structure with solid proliferation of round cells, representing the typical appearance of oligodendroglioma (Fig. 3). Most neoplastic cells were round in shape with abundant clear cytoplasm and hyperchromatic central nuclei. The presence of cytoplasmic processes was not confirmed. In the tumor there were a number of blood vessels with thin vascular walls, while the endothelial cells did not show apparent hyperplastic or proliferative changes. There were also a few of well differentiated astrocytes with well defined eosinophilic cytoplasmic processes in the neoplastic foci.In contrast, at the periphery of the neoplastic foci, diffuse proliferation of these astrocytes was prominent. Within the cystic spaces, there were aggregates of small number of small round cells mimicking lymphocytes, with small hyperchromatic round nuclei and scanty cytoplasm. Mitoses of the neoplastic cells were extremely rare. The neoplastic cells invaded the leptomeninges, and the subarachnoidal space was filled by a proliferation of these cells. Diffuse and multifocal proliferation of the round cells and lymphocyte-like small round cells, were also seen in the subarachnoidal space in the 2nd and 3rd levels of the sacral spinal cord (Fig. 4). In this area, some foci consisted of aggregates of neoplastic cells, and some areas showed an organoid structure made up of tumor cells, a few astrocytes and their cytoplasmic processes (Fig. 5). Besides the spinal cord there was no ...

show abstract

“…Central neurocytomas (CNs) are intraventricular central nervous system (CNS) neoplasms first described by Hassoun et al [1] in 1982 and which are now regarded as a well-established clinicopathological entity and classified as a World Health Organization (WHO) grade II tumor [2]. Typically, they are located in the lateral ventricles in the region of the foramen of Monroe and affect young adults between 20 and 40 years of age [2].…”

Section: Introductionmentioning

confidence: 99%

Cytologic Features during Intraoperative Assessment of Central Neurocytoma: A Report of Three Cases and Review of the Literature

Hernandez-Martinez

Leíja-Portilla²,

Medellín-Sánchez³

2013

Acta Cytologica

View full text Add to dashboard Cite

Background: Central neurocytomas (CNs) are infrequent intraventricular tumors with features of neuronal differentiation that affect young adults and have an excellent prognosis after total resection. The main differential intraoperative diagnoses are oligodendrogliomas, ependymomas and non-Hodgkin's lymphomas; therefore, an accurate and precise intraoperative diagnosis is essential, making the cytologic features the hallmark for cytopathologists, surgical pathologists and neurosurgeons alike. Seven previous reports have described 18 cases of CNs and have addressed the cytodiagnostic criteria during intraoperative assessment in the English medical literature. Cases: Three patients (23 years old/male, 29 years old/female and 28 years old/male) were evaluated during intraoperative assessment as CNs. They showed intraventricular tumors that measured 6.5, 3.5 and 6.6 cm, respectively. The cytologic features common in these cases were: (1) monotonous or isomorphic round cells, (2) small nuclei with stippled or granular chromatin, and (3) acellular fibrillary areas or neuropil (islands). Other cytologic features often encountered were: rosette-like structures, micronucleoli, perinuclear haloes, well-formed capillary-sized vessels and calcifications. Conclusion: Differential diagnosis of CNs can be a diagnostic challenge. The integration of radiologic imaging and touch preparations taking into account specific cytologic features and frozen sections is necessary for an optimal intraoperative assessment.

show abstract

Central neurocytoma

Cited by 488 publications

References 21 publications

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

Cerebellar Extraventricular Neurocytoma With Spinal Seeding

Spinal Oligodendroglioma with Diffuse Arachnoidal Dissemination in a Japanese Black Heifer.

Cytologic Features during Intraoperative Assessment of Central Neurocytoma: A Report of Three Cases and Review of the Literature

Contact Info

Product

Resources

About