Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examination Survey 2011–2012

Rim, John Hoon; Lee, Yong-Ho; Soo, Bong; Lee, Sang-Guk; Kim, Jeong-Ho

doi:10.1016/j.cca.2015.06.010

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Os riscos se tornam maiores quando há aumento da pressão arterial, como a população investigada no presente estudo. Alguns estudos mostram resultados semelhantes, nos quais os participantes portadores de alterações simultâneas nas concentrações plasmáticas de TG e na medida da CC, apresentaram níveis pressóricos mais elevados que os indivíduos que apresentavam tais parâmetros dentro da normalidade 26,27,29 . O Hoorn Study indicou que homens e mulheres cintura hipertrigliceridêmica se encontravam com risco aumentado para doença cardiovascular, mesmo quando apresentavam o metabolismo de glicose dentro dos parâmetros considerados normais 23,22 .…”

Section: Discussionunclassified

Fenótipo de cintura hipertrigliceridêmica e lesão renal em pacientes hipertensos

Medeiros¹,

Monteiro²,

Júnior³

et al. 2021

SaudColetiv (Barueri)

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Objetivo: Verificar a associação entre o fenótipo de cintura hipertrigliceridêmica (FCH) e a estimativa da taxa de filtração glomerular (eTFG) em pacientes hipertensos. Método: Tratou-se de um estudo transversal e retrospectivo, composto por 146 prontuários de hipertensos consultados entre os anos de 2013 a 2017 no Centro de Prevenção de Doenças Renais HUUFMA. Considerou-se dados sociodemográficos, condições clínicas e exames laboratoriais, estes foram analisados pelo programa estatístico SPSS 21.0®. Resultados: O FCH esteve presente em 84,2% (n=123) da amostra e 65% (n=, desta, eram mulheres. A eRFG apresentou média de 69,3 ± 23,9 mL / min em 1,73 m² no grupo com FCH e média de 91,4 ± 42,6 mL / min em 1,73 m² no grupo sem FCH, com associação significativa (p <0,05). Conclusões: A presença do FHC associou-se à diminuição da eTFG, ao aumento dos exames laboratoriais, medidas antropométricas e índices antropométricos.

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Section: Discussionunclassified

Fenótipo de cintura hipertrigliceridêmica e lesão renal em pacientes hipertensos

Medeiros¹,

Monteiro²,

Júnior³

et al. 2021

SaudColetiv (Barueri)

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“…Our ndings are consistent with previous clinical studies in which abnormal lipid metabolism and central obesity triggered microalbuminuria excretion, particularly in female patients with T2DM. A study based on the Korean National Health and Nutrition Examination Survey found that obese female patients were more likely to develop microalbuminuria and that impaired fasting glucose and high triglycerides were signi cant correlates of microalbuminuria [39]. The interaction of increased glucose exposure with abnormal lipid metabolism associated with central obesity may be one of the leading causes of vascular endothelial dysfunction and microalbuminuria excretion in a 5398 Korean general population [40].…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Cardiometabolic Index and Microalbuminuria in Type 2 Diabetic Patients

Jiang

Hao

et al. 2021

Preprint

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Background: In recent years, cardiometabolic index (CMI) has been introduced to predict the risk of diabetes in the general population and is also strongly associated with cardiovascular disease, hypertension, and ischemic stroke, but the relationship between CMI and diabetic microalbuminuria remains unclear. This study intends to investigate the relationship between CMI and microalbuminuria in patients with type 2 diabetes mellitus(T2DM). Methods: 524 subjects (mean age 57.28 ± 10.52 years, 283 males and 241 females) from the Department of Endocrinology, Southwestern Medical University Hospital, China (data collected from June 2017 to June 2019) participated in this study. CMI was calculated by triglyceride to high-density lipoprotein cholesterol ratio(TG/HDL-C) multiply waist-to-height ratio(WHtR). Microalbuminuria was identified by the urinary albumin‐to‐creatinine ratio (UACR) when the value was between 30–300 mg/g. Multivariate logistic regression aimed to explore the association between CMI and diabetic microalbuminuria; The receiver operating characteristic (ROC) analysis was employed to evaluate the predictive value of CMI for microalbuminuria in T2DM patients. Results: The prevalence of microalbuminuria in all participants was 37.8% in men and 41.1% in women. Regardless of gender, CMI was significantly more unfavorable in the microalbuminuria group. The incidence of microalbuminuria increased dose-responsively with increasing CMI quartiles. Modeling CMI as a continuous variable in a multivariate-adjusted model, we observed an independent effect of each 1 SD increase in CMI on the risk of developing microalbuminuria. The relationship was more pronounced in women than in men. In women, the odds ratio(OR) for microalbuminuria was 5.666 (95% CI: 2.247-14.289) in the highest quartile of CMI compared with the lowest quartile; in men, the OR was nearly 4-fold increased(OR: 4.667, 95% CI: 1.910-11.405) in the same situation. The AUC for CMI was 0.681 (0.613 to 0.749) in women and 0.648 (0.582-0.713) in men. Conclusion: High levels of CMI were independently associated with diabetic microalbuminuria, and CMI, a novel index covering lipids and central obesity, explained the gender differences in obesity-related microalbuminuria excretion, an effect that was substantially increased in women. The results of this study provide important insights into the potential usefulness and clinical relevance of CMI for microalbuminuria in Chinese patients with T2DM.Registration number: ChiCTR2100047930Date of registration: On June 27, 2021 (retrospectively registered)

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“…Logo, estudos futuros devem avaliar a influência do gênero na presença do FCH.A apesar de não apresenta diferença significativa, cabe chamar atenção, que a amostra de pacientes com FCH, teve a média de idade maior que o grupo sem FCH. A idade avançada é um fator que coopera para desencadear a doença renal e pacientes com idade mais avançada são predominantes quanto à presença de FHC, devido a fatores como: alterações fisiológicas, mudança na composição corporal, perda de massa magra, acúmulo de gordura na região abdominal, o que aumenta também a taxa de doenças crônicas nesses pacientes(RIM et al, 2015).A DRC está associada a distúrbios fisiológicos e metabólicos de prevalência mundial elevada, como hipertensão, obesidade, resistência à insulina, doenças cardiovasculares e envelhecimento, que também são fatores de risco para a patogênese e progressão da DRC(JUSZCZAK et al, 2020). Nesse contexto,Mota et al (2016) observou uma prevalência do FCH em 30% dos homens hipertensos da sua amostra, em contrapartida de 26,3%de mulheres hipertensas com FCH.…”

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Pré-Natal Do Homem: Uma Nova Dinâmica Sobre a Saúde Masculina

Silveira¹,

Serra²,

Serra³

2021

Saúde Coletiva: Uma Abordagem Multidisciplinar 2

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Central obesity is an independent risk factor for microalbuminuria in both the general Korean women and nondiabetic nonhypertensive subpopulation: Association of microalbuminuria and metabolic syndrome from the Korea National Health and Nutrition Examination Survey 2011–2012

Cited by 6 publications

References 33 publications

Fenótipo de cintura hipertrigliceridêmica e lesão renal em pacientes hipertensos

Fenótipo de cintura hipertrigliceridêmica e lesão renal em pacientes hipertensos

Correlation Between Cardiometabolic Index and Microalbuminuria in Type 2 Diabetic Patients

Pré-Natal Do Homem: Uma Nova Dinâmica Sobre a Saúde Masculina

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