Central odontogenic fibroma: new findings and report of a multicentric collaborative study

Mosqueda‐Taylor, Adalberto; Martínez-Mata, Guillermo; Carlos-Bregni, Román; Vargas, Pablo Agustı́n; Toral-Rizo, Víctor Hugo; Cano-Valdez, Ana Marı́a; Palma-Guzmán, José Mario; Carrasco-Daza, Daniel; Luna-Ortiz, Kuauhyama; Ledesma‐Montes, Constantino; Almeida, Oslei Paes de

doi:10.1016/j.tripleo.2011.03.021

Cited by 69 publications

(83 citation statements)

References 46 publications

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“…These authors confirmed that the epithelial component had a very similar pattern of cytokeratin expression as seen in other odontogenic epithelia, namely expressing AE1/AE3, CK5, CK14, CK19, and 34bE12 and negative for CK1 and CK18. There were two cases weakly positive for CK7 and CK8 [43]. The mesenchyme expressed vimentin and occasional cells expressed SMA.…”

Section: Odontogenic Fibroma (Of)mentioning

confidence: 95%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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The diagnosis of odontogenic tumors can be challenging, largely due to their rarity and consequent difficulties in gaining experience in their assessment. In most cases, careful attention to morphology, in conjunction with clinical and radiological features will allow a diagnosis to be made. However, in some cases, immunohistochemical analysis of the tumor may be useful. In this review we will outline the immunohistochemical expression profile of normal developing odontogenic tissues and a range of odontogenic tumors. In many cases the immunohistochemical markers are neither specific nor sensitive enough to be of help in diagnosis, but in some cases such analysis may prove very useful. Thus we have outlined a limited number of circumstances where immunohistochemistry may be of use to the practicing diagnostic pathologist.

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Section: Odontogenic Fibroma (Of)mentioning

confidence: 95%

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Hunter

Speight

2014

Head and Neck Pathol

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“…In fact, five of the nine previously reported cases occurred at a molar site of the mandible [5][6][7] . On the other hand, only one case 9) was previously reported the diagnosis of an epithelium-poor type COF at the anterior region of the mandible and the present case was second epithelium-poor type COF arising at the anterior region of the mandible. COFs are less frequently seen in this region.…”

Section: Discussionmentioning

confidence: 44%

“…COFs are less frequently seen in this region. Since these tumors tend to gradually increase in size without any symptoms, they are usually discovered incidentally by dental radiographic examinations during general dental care [8][9][10] . Bone bulging also developed gradually without pain or other symptoms in this case.…”

Section: Discussionmentioning

confidence: 99%

Epithelium-Poor Type Central Odontogenic Fibroma: An Immunohistological Study and Review of the Literature

Kimura

Ohba

Yoshimura

et al. 2013

J. Hard Tissue Biology.

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The object of this study was to determine the characteristics of central odontogenic fibroma (COF) in order to help achieve a correct diagnosis. Central odontogenic fibroma, which tends to be epithelium-poor, is an extremely rare type of odontogenic fibroma. The lack of data concerning COF, due to its low incidence, can make this entity difficult to diagnose. We herein report an epithelium-poor type of COF of the mandible, which we examined immunohistologically. We also provide a review of the previous English literature to expand the knowledge about this disease. Positive reactions for vimentin and negative reactions for desmin and -smooth muscle actin ( -SMA) in COFs were common findings in the previous reports. We also noted similar immunohistological findings. Our data (vimentin positive, -SMA and desmin negative) should contribute to correctly diagnosing epithelium-poor type COF.

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“…28,29 Ayrıca fibroblastlarda, epidermal dendiritik hüc-relerde, astrosit ve mikroglia hücrelerinde, dev hücreler ve osteoklastlarda CD68 sunumu göste-rilmiştir. [30][31][32][33][34] Nötrofillerin primer granüllerinde bulunur. İltihabi reaksiyonlarda sunumunun arttığı bildirilmiştir.…”

Section: Cd4+ Cd8+unclassified

Analysis of Inflammatory Cells with Immunuhistochemical Method in Bronchoalveolar Lavage Fluids of Sarcoidosis Patients

Dağıstanlı¹,

Tunçdemi̇r²,

Kaner³

et al. 2012

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T AAm ma aç ç: : Sarkoidoz patogenezi iyi bilinmeyen sistemik bir hastalıktır. Olguların %50'sinde akciğer tutulumu görülür. Pulmoner sarkoidozla birlikte görülen kontrolsüz T hücresi proliferasyonu ve zararlı kimyasal mediyatörlerin salınması gibi patolojik olaylar immünolojik mekanizmalar ile açıklanabilir. Pulmoner sarkoidozda Th1 sitokinlerinin ve makrofaj aktivasyonu ile ilgili sitokinlerin sunumunun tercih edildiğini gösteren çalış-malar mevcut olmakla birlikte, sitokin sunumu konusunda yeterince çalışılmamıştır. Bu çalışmada, sarkoidozlu hastaların akciğerlerinde görülen yangısal olayların başlaması ve devamından sorumlu olan hücre tiplerini ve bu yangısal reaksiyonları yönlendirmede önemli olabilecek sitokinlerin sunumunu araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmada 7 sarkoidozlu hasta ile 7 sağlıklı kontrolden alınan bronkoalveolar lavaj (BAL) sıvısından sitosantrüfüjde hazırlanan preparatlar kullanıldı. Tüm örneklere CD4 ve CD8 monoklonal antikorları ile immün boyama yapılarak T hücresi alt tiplerinin dağılımı araştırıldı. Ayrıca T yardımcı-1(Th1) tipi sitokinlerden olan interferon gama (IFNγ) ve bir makrofaj belirteci olan CD68 ekspresyonu da immünohistokimyasal olarak incelendi. B Bu ul lg gu ul la ar r: : Sarkoidozlu hastaların BAL sıvılarından hazırlanan sitosantrifüj preparatlarında lenfosit sayısında sağlıklı kontrol grubuna kıyasla anlamlı (p=0,002) bir artış saptandı. T lenfositi alt gruplarının incelenmesi sonucunda CD4(+) yardımcı T hücrelerinin (Th) (%21,59±0,87) CD8(+) baskılayıcı T hücrelerine (Ts) (%10,40±0,59) kıyasla çoğunlukta olduğu gözlendi. Th/Ts (CD4+/CD8+) oranı sarkoidoz grubunda 2/1 olarak saptandı. Sarkoidozlu hastaların BAL preparatlarında IFNγ sunumu yapan T hücrelerine rastlandı. CD68 sunumu, sarkoidozlu gruptaki makrofajların yanı sıra, bazı dev hücreler, lenfositler ve polimorf nüveli lökositlerde de görüldü. S So on nu uç ç: : Bulgularımız, yardımcı T lenfositlerdeki artışın, sarkoidoz patogenezine katılan önemli bir faktör olduğunu ve artmış lenfositlerin Th1 tipi sitokinlerin sunumunu tercih ettiğini göstermektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Sarkoidoz; CD4-pozitif T-lenfositler; CD8-pozitif T-lenfositler; makrofajlar, alveolar; CD68 antigeni, insan; IFN-gama(95-132) peptit A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Sarcoidosis is a systemic disease with an unclear pathogenesis. Pulmonary involvement develops in 50% of cases. Pathologic events like uncontrolled T cell proliferation and release of harmful mediators seen in pulmonary sarcoidosis may be explained with immunologic mechanisms. Pulmonary sarcoidosis has been shown to be related to an increased production of Th1 cytokines and an activation of macrophages. However, cytokine expression in sarcoidosis has not been systematically studied yet. In this study, we aimed to investigate the cell types responsible for initiation and maintanence of inflammatory reactions in the lungs of sarcoidosis patients and expression of cytokin...

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Central odontogenic fibroma: new findings and report of a multicentric collaborative study

Cited by 69 publications

References 46 publications

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

The Diagnostic Usefulness of Immunohistochemistry for Odontogenic Lesions

Epithelium-Poor Type Central Odontogenic Fibroma: An Immunohistological Study and Review of the Literature

Analysis of Inflammatory Cells with Immunuhistochemical Method in Bronchoalveolar Lavage Fluids of Sarcoidosis Patients

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