Central odontogenic granular cell tumor of the jaw

Central odontogenic fibroma: an international multicentric study of 62 cases

“…Immunohistochemical and ultrastructural studies of the granular cells have shown, respectively, positive stains for CD68 and cytoplasmic structures consistent with lysosomes. 28 In 2 cases of the present study (cases 4 and 45), granular cells were positive in membrane pattern for CD163, a monocyte-/macrophage-derived differentiation antigen limited to neoplasms of monocyte/histiocyte derivation, indicating a histiocytic differentiation of stromal granular cells of COdF. CD138 (syndecan-1) is a cell surface proteoglycan that modulates epithelial-stromal interactions, cell-cell adhesion, and cell proliferation.…”

Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report

“…Histopathologically, this odontogenic tumor was characterized by varying amount of large eosinophilic granular cells with eccentrical nuclei and apparently inactive odontogenic epithelium [1][2][3][4][5][6][7][8][9][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] , similar to this case. Epithelial cells containing a clear cytoplasm were a common feature [6,13,16,19,20,37,38] .…”

“…Our search identified a total of 53 articles, of which 36 were eligible, [1][2][3][4][5][6][7][8][9][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] . We identified a total of 51 cases from the 36 articles published since 1950 to September 2021.…”

“…Dalforno and Donna [3] named this lesion "ameloblastic fibroma with stroma of granular cells". Later, other investigators also named this tumor "central granular cell tumor of the jaws" [4,29] , "central granular cell odontogenic fibroma" [5,7] , "central odontogenic fibroma, granular cell variant" [6,36,37] , and "central odontogenic granular cell tumor" [30,34,35] . Most investigators currently prefer to use the designation "central granular cell odontogenic tumor" [8,[12][13][14][15][16][17][18][19][20][21][22][23][24] , and we also use this term.…”