Central Opioidergic System Interplay with Histamine on Food Intake in Neonatal Chicks: Role of µ-Opioid and H1/H3 Receptors

Jaefari-Anari, M.; Zendehdel, Morteza; Gilanpour, H; Asghari, Ahamd; Babapour, Vahab

doi:10.1590/1806-9061-2018-0785

Cited by 7 publications

(3 citation statements)

References 44 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, orofacial nociception intensity was not changed by intra-NAc microinjection of naloxone; however, it reversed the antinociceptive effect of histamine, dimaprit and thioperamide. Central opioidergic system interaction with histamine system was documented in several studies (Tamaddonfard et al ., 2011; Jaefari-Anari et al ., 2018; Salimi et al ., 2021). In this regard, an interaction was found when naloxone was applied with histamine H 2 and H 3 receptors at the cerebral cortex areas (Tamaddonfard and Hamzeh-Gooshchi, 2014; Hamzeh-Gooshchi et al ., 2015), hippocampus (Khalilzadeh et al ., 2010a; Tamaddonfard et al ., 2011), and thalamic submedius nucleus (Erfanparast et al ., 2015) in modulation of formalin-induced nociception in rats.…”

Section: Discussionmentioning

confidence: 99%

Exogenous histamine and H2 receptor activation and H3 receptor inhibition in nucleus accumbens modulate formalin-induced orofacial nociception through opioid receptors

Notaj

Erfanparast

Tamaddonfard

et al. 2023

Behavioural Pharmacology

View full text Add to dashboard Cite

It has been demonstrated that the nucleus accumbens (NAc) plays an important role in modulation of nociception due to its extensive connections with different regions of the brain. In addition, this nucleus receives histaminergic projections from tuberomammillary nucleus. Considering the role of the central histaminergic system in nociception, the effect of histamine and its H2 and H3 receptors agonist and antagonist microinjections into the NAc on orofacial formalin nociception was investigated. In male Wistar rats, using stereotaxic surgery, two guide cannulas were bilaterally implanted into the right and left sides of the NAc. Diluted formalin solution (1.5%, 50 µl) injection into the vibrissa pad led to orofacial nociception. Immediately after injection, face rubbing was observed at 3-min blocks for 45 min. Orofacial formalin nociception was characterized by a biphasic nociceptive response (first phase: 0–3 min and second phase: 15–33 min). Microinjections of histamine (0.5 and 1 μg/site), dimaprit (1 μg/site, H2 receptor agonist) and thioperamide (2 μg/site, H3 receptor antagonist) attenuated both phases of formalin orofacial nociception. Prior microinjection of famotidine (2 μg/site) inhibited the antinociceptive effects of dimaprit (1 μg/site). Furthermore, comicroinjection of thioperamide (2 μg/site) and immepip (1 μg/site) prevented thioperamide (2 μg/site)-induced antinociception. Naloxone (2 μg/site) also prevented histamine, dimaprit- and thioperamide-induced antinociception. The results of this study demonstrate that at the level of the NAc, histamine and its H2 and H3 receptors are probably involved in the modulation of orofacial nociception with an opioid system-dependent mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Exogenous histamine and H2 receptor activation and H3 receptor inhibition in nucleus accumbens modulate formalin-induced orofacial nociception through opioid receptors

Notaj

Erfanparast

Tamaddonfard

et al. 2023

Behavioural Pharmacology

View full text Add to dashboard Cite

show abstract

“…The µ receptor of opioid declines food consumption in chicken; however, other receptors enhance food desire (Zendehdel et al 2016). There are some interactions between opioids and other brain mediators such as 5-HT (Shojaei et al 2015), histamine (Jaefari et al 2018), NE (Nayebzadeh et al 2020), CBs (Zendehdel et al 2015c), glutamate (Torkzaban et al 2018), nitric oxide (NO) (Alimohammadi et al 2015), and OT (Raji-Dahmardeh); given this, the reduction effect of DAMGO (µ-opioid receptor agonist) is amplified by CB 1 and CB 2 receptors antagonist, H 3 receptor antagonist, and L-arginine (the precursor of NO) whereas that is diminished by NMDA and mGlu1 receptors antagonist, OT antagonist, β 2 receptor antagonist, H 1 receptors antagonist, and 5-HT 2c receptor antagonist. Also, DPDPE (δ-opioid receptors agonist) induced hyperphagia is decreased by α 1 receptor antagonist, while that is increased by AMPA glutamate receptors antagonist.…”

Section: Opioidsmentioning

confidence: 99%

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Rahmani

Ghashghayi

Zendehdel

et al. 2021

Int J Pept Res Ther

View full text Add to dashboard Cite

Appetite is controlled by a complex system of central and peripheral signals interacting to modulate the ingestion response. Several brain mediators with complex networks adjust food intake in birds. Based on the available literature, these mediators have interactions with a number of other neurotransmitters (NT S ) involved in feed intake. It means that, NT S regulate feeding behavior through mediating other peptide and NTs activity. In birds, insulin known as a hypophagic hormone that is interplaying with neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and corticotropin-releasing factor (CRF) in brain. Another hormone ghrelin, inhibits food intake in birds and other mediators, such as glutamate, endocannabinoid system (ECS), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine (NE), which play a key role in ghrelin-induced hypophagia. Another involved peptide on feeding behavior in chickens called nociceptin/orphanin FQ (N/OFQ) is modulated by histamine, glutamate, dopamine (DA), gamma-aminobutyric acid (GABA), agouti-related protein (AgRP), and cocaine and amphetamine-regulated transcript (CART). Some of the NT S such as opioid have both orexigenic and anorexigenic effects in birds while has interaction with NE, glutamate, histamine, DA, and cannabinoids (CBs). Thus, interaction among mediators is a prominent process needs to be considered in order to understanding the mechanisms underlying feed intake regulation in birds. This review aims to investigate the role of major regulators and their mediatory interactions with one another in poultry feeding behavior. According to mentioned interactions, it seems that dopamine, serotonin, and glutamate have the most interactions with other NT systems. Therefore, they play an axial role in the central regulation of food intake in CNS.

show abstract

“…Opioids are known as inhibitory neurotransmitters that have been connected to several acts, including pain adjustment, respiratory function, neuroendocrine and reward situation, and feeding regulation (Jaefari-Anari et al 2018). Nutrition intake was demonstrated to be changed at the time that treatments with opioid receptors agonists such as mu (µ), delta (δ), and kappa (κ) were started.…”

Section: Introductionmentioning

confidence: 99%

The Effect of the Central Administration of the Neuropeptide VF on Feed Intake and Its Possible Interactions with Glutamate and Opioid Systems in Broiler Chicken

Hamidi

Zendehdel

Vazir

et al. 2022

Int J Pept Res Ther

View full text Add to dashboard Cite

Arginine-phenylalanine-amide (RFamide)-related peptides (RFRP) known as neuropeptide VF (NPVF) have a crucial role in feeding regulation. The present study purposed to determine the effect of intracerebroventricular (ICV) injection of the NPVF on dietary intake and possible interactions of NPVF with glutamate and opioid systems in broiler chicken. In experiment 1, chickens received ICV administration of the control solution, NPVF (16 nmol), 15 nmol of MK-801 (NMDA glutamate receptors antagonist), and injection of the NPVF with MK-801 together. In experiments, 2-8 chicken injected intracerebroventricularly with 390 nmol of CNQX (antagonist of AMPA glutamate receptors), 2 nmol of AIDA (an antagonist of mGLUR 1 glutamate receptors), 150 nmol of LY341495 (an antagonist of mGLUR 2 glutamate receptors), 2 nmol of UBP1112 (an antagonist for mGLUR 3 glutamate receptors), 5 µg of β-FNA (an antagonist for mu (µ) receptors), 5 µg of NTI (an antagonist for delta (δ) receptors), nor-BNI (kappa (κ) receptors antagonist; 5 µg) instead of MK-801. Following the injection, at 30, 60, and 120 min, the chick's dietary intake was recorded. As a result, NPVF (16 nmol) reduced feed intake in broilers (P<0.05). NPVF + MK-801 co-injection reduced the hypophagic action of the NPVF (P<0.05). Injection of NPVF + CNQX together reduced the anorectic action of NPVF (P<0.05). Co-injection of NPVF + β-FNA reduced effects of NPVF injection (P<0.05). Thus, in newborn broilers, NPVF-induced anorexia is probably mediated by NMDA/ AMPA glutamate and µ opioid receptors.

show abstract

Central Opioidergic System Interplay with Histamine on Food Intake in Neonatal Chicks: Role of µ-Opioid and H1/H3 Receptors

Cited by 7 publications

References 44 publications

Exogenous histamine and H2 receptor activation and H3 receptor inhibition in nucleus accumbens modulate formalin-induced orofacial nociception through opioid receptors

Exogenous histamine and H2 receptor activation and H3 receptor inhibition in nucleus accumbens modulate formalin-induced orofacial nociception through opioid receptors

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

The Effect of the Central Administration of the Neuropeptide VF on Feed Intake and Its Possible Interactions with Glutamate and Opioid Systems in Broiler Chicken

Contact Info

Product

Resources

About