Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

Arakawa, Hiroyuki; Blanchard, D. Caroline; Blanchard, Robert J.

doi:10.1016/j.physbeh.2015.04.016

Cited by 37 publications

(24 citation statements)

References 85 publications

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“…Mating with a female that has already mated or is not attractive may be costly for males in that it increases sperm competition and reduces his likelihood of paternity. Similar conclusions about the role of familiarity and responses to scent marks have been adduced for house mice [ 68 , 98 ] and the white-footed sportive lemur, Lepilemur leucopus [ 99 ].…”

Section: Introduction and Overviewsupporting

confidence: 54%

Odor Communication and Mate Choice in Rodents

Ferkin

2018

Biology

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This paper details how chemical communication is affected by ecological challenges such as finding mates. I list several conditions that affect the decision to attract mates, the decision to respond to the signals of potential mates and how the response depends on context. These mate-choice decisions and their outcomes will depend on the life history constraints placed on individuals such as their fecundity, sex, lifespan, opportunities to mate in the future and age at senescence. Consequently, the sender’s decision to scent mark or self-groom as well as the receiver’s choice of response represents a tradeoff between the current costs of the participant’s own survival and future reproduction against that of reproducing now. The decision to scent mark and the response to the scent mark of opposite-sex conspecifics should maximize the fitness of the participants in that context.

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Section: Introduction and Overviewsupporting

confidence: 54%

Odor Communication and Mate Choice in Rodents

Ferkin

2018

Biology

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“…While the majority of studies investigating the role of OT in aggressive/agonistic behaviors have reported a mitigating effect ( Arakawa et al., 2015 , Calcagnoli et al., 2013 , Calcagnoli et al., 2014 , Calcagnoli et al., 2015 , Dhakar et al., 2012 , Jong et al., 2014 , Karpova et al., 2016 , Ragnauth et al., 2005 , Sala et al., 2011 , Takayanagi et al., 2005 , Tan et al., 2019 , Winslow et al., 2000 , Zoratto et al., 2018 ), a few others have indicated that OT can potentially increase such behaviors ( DeVries et al., 1997 , Lazzari et al., 2013 , Pagani et al., 2015 ). One study even showed the differential effects of OT in rats selectively bred for aggression or tameness toward humans, with a 5-day intranasal treatment reducing aggressive behavior in the aggressive strain but increasing it in the tame strain ( Gulevich et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Anpilov

Shemesh

Eren

et al. 2020

Neuron

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Summary Complex behavioral phenotyping techniques are becoming more prevalent in the field of behavioral neuroscience, and thus methods for manipulating neuronal activity must be adapted to fit into such paradigms. Here, we present a head-mounted, magnetically activated device for wireless optogenetic manipulation that is compact, simple to construct, and suitable for use in group-living mice in an enriched semi-natural arena over several days. Using this device, we demonstrate that repeated activation of oxytocin neurons in male mice can have different effects on pro-social and agonistic behaviors, depending on the social context. Our findings support the social salience hypothesis of oxytocin and emphasize the importance of the environment in the study of social neuromodulators. Our wireless optogenetic device can be easily adapted for use in a variety of behavioral paradigms, which are normally hindered by tethered light delivery or a limited environment.

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“…“Sitting alone” defined as a position of a mouse in a cage without any physical contacts to another cage mate(s). Time spent in motion was defined as an appearance of horizontal movement of an animal where a position of a centre of a body changed in a cage with a speed > 2 cm/sec or an animal would display a rearing by taking a vertical position for >1 sec, as defined previously [38]. To evaluate digging (burrowing) behaviour, a species-specific behaviour of a displacement of bedding material using the snout and forepaws, percentage of mice that display this form of behaviour was calculated in each group; its total duration for an observation period was evaluated as well.…”

Section: Methodsmentioning

confidence: 99%

Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice

et al. 2017

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Nonalcoholic fatty liver disease, induced by a Western diet (WD), evokes central and peripheral inflammation that is accompanied by altered emotionality. These changes can be associated with abnormalities in social behaviour, hippocampus-dependent cognitive functions, and metabolism. Female C57BL/6J mice were fed with a regular chow or with a WD containing 0.2% of cholesterol and 21% of saturated fat for three weeks. WD-treated mice exhibited increased social avoidance, crawl-over and digging behaviours, decreased body-body contacts, and hyperlocomotion. The WD-fed group also displayed deficits in hippocampal-dependent performance such as contextual memory in a fear conditioning and pellet displacement paradigms. A reduction in glucose tolerance and elevated levels of serum cholesterol and leptin were also associated with the WD. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1a) mRNA, a marker of mitochondrial activity, was decreased in the prefrontal cortex, hippocampus, hypothalamus, and dorsal raphe, suggesting suppressed brain mitochondrial functions, but not in the liver. This is the first report to show that a WD can profoundly suppress social interactions and induce dominant-like behaviours in naïve adult mice. The spectrum of behaviours that were found to be induced are reminiscent of symptoms associated with autism, and, if paralleled in humans, suggest that a WD might exacerbate autism spectrum disorder.

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Central oxytocin regulates social familiarity and scent marking behavior that involves amicable odor signals between male mice

Cited by 37 publications

References 85 publications

Odor Communication and Mate Choice in Rodents

Odor Communication and Mate Choice in Rodents

Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors

Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice

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