Central regulation of food intake in mammals and birds: a review

Zendehdel, Morteza; Hassanpour, Shahin

doi:10.14800/nt.251

Cited by 7 publications

(5 citation statements)

References 69 publications

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“…The dopamine concentration in the feed restricted group was higher than the ad libitum group. Our result may be supported by that previous finding that the intracerebroventricular injection of dopamine decreases food intake in chickens (37), and further confirms the association of dopamine with feed intake (22,23). One reason may be that feed restriction stimulates a greater state of excitement in the birds when feeding owing to their greater hunger.…”

Section: Discussionsupporting

confidence: 91%

“…In chickens, it is additionally responsible for neuroplasticity (20) and altering dopaminergic components of the hippocampus (21). On the other hand, dopamine, a major catecholamine neurotransmitter in the central nervous system of mammals and birds, was known to be affected by learning ability, food intake behaviors, and feed restriction (22)(23)(24), and can modulate the hippocampal synaptic plasticity (25). That is, therefore, we think that dopamine may act in a role connecting behavior and neuron activity of hippocampal transcriptome in response to feed restriction.…”

Section: Introductionmentioning

confidence: 99%

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Domestication and Feed Restriction Programming Organ Index, Dopamine, and Hippocampal Transcriptome Profile in Chickens

et al. 2021

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The domestication process exerts different phenotypic plasticity between slow- and fast-growing breeds of chicken. Feed restriction has a critical role in production performance, physiological plasticity, and stress response. Our study aimed to explore how feed restriction programed the organ index, dopamine, and hippocampal transcriptome profile between slow- and fast-growing chickens, which were fed either ad libitum (SA and FA), or feed restricted to 70% of ad libitum (SR and FR), for 30 days. Results showed that feed restriction influenced the brain organ index (P < 0.05), but not the organ index of the heart, liver, and spleen. The slow-growing breed tested had a higher brain organ index than the fast-growing breed (P < 0.05). Under feed restriction conditions, both the slow- and fast-growing breeds had significantly elevated dopamine concentrations (P < 0.05) compared to those fed ad libitum. In the GO term, upregulated genes in the FA group were enriched in the mitochondria, respiratory chain, and energy metabolism compared to the SA group (P < 0.05). Membranes and ribosomes were enriched in the cellular component between the SR and FR groups (P < 0.05). In the KEGG functional pathways, upregulated DEGs in the FR group were enriched in the cardiovascular disease category and neurodegenerative disease category compared to the FA group (P < 0.05). Downregulated DEGs in the FA group were enriched in the oxidative phosphorylation and neurodegenerative disease categories (Parkinson's disease and Huntington's disease) compared with the SA group (P < 0.05). Upregulated DEGs in the FR group were enriched in the cardiovascular disease category, neurodegenerative disease category, and energy metabolism than the SR group (P < 0.05). In conclusion, feed restriction had profound effects on the brain organ index and plasma dopamine in the slow- and fast-growing chickens. Feed restriction may result in issues relating to cardiovascular and neurodegenerative diseases in the fast-growing breed tested, but not in the slow-growing breed.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Domestication and Feed Restriction Programming Organ Index, Dopamine, and Hippocampal Transcriptome Profile in Chickens

et al. 2021

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“…These results suggested that 5-HT hypophagia and hyperdipsia were mediated by different mechanisms in the central nervous system ( Zendehdel et al, 2012a ). It is showed that there is a neural interaction between serotonergic systems and melanocortin in terms of nutritional behavior in broilers ( Zendehdel and Hassanpour, 2014 ). The 5-HT affects the centers that regulate nutrition and energy balance ( Zendehdel et al, 2012b ).…”

Section: Discussionmentioning

confidence: 99%

The effect of spexin injection and its interaction with nitric oxide, serotonin, and corticotropin receptors on the central regulation of food intake in broilers

Farzin,

Hassanpour,

Zendehdel

et al. 2024

IBRO Neuroscience Reports

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“…The mechanism of food intake regulation has been well-demonstrated in mammals as food intake is a complex biological process, involving in both the peripheral and central nervous system (CNS) control mechanisms ( 4 ). Like in mammals, the CNS, specifically the hypothalamus, has emerged as a key site in appetite control for birds ( 5 ), and are potentially involved in the regulation of birds' feed intake under stress.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation With Yucca Alleviates Heat Stress in Growing Broilers Exposed to High Ambient Temperature

Luo

Chen

et al. 2022

Front. Vet. Sci.

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Yucca contains high a content of saponin that has a glucocorticord-like effect in animals, e.g., anti-inflammation and anti-microbiota. The objective of the present study was to test the hypothesis that dietary supplementation of yucca powder may alleviate heat stress and improve growth performance of growing broilers subjected to cycling high ambient temperature. A total of 240 male broiler chicks (yellow feathered chicken) aged 28 days, with body weight (BW) of 792 ± 43.7 g, were randomly allocated to one of four treatments (6 replicates per treatment): control (normal temperature, 24 ± 2°C, 24 h), fed diets supplemented with 100 mg/kg yucca under normal temperature (Y), high ambient temperature exposure (HT, 34 ± 2°C, 11 h), fed diets supplemented with 100 mg/kg yucca (HT+Y) under high ambient temperature. After 7 days of adaption, the experiment was conducted for 4 weeks (aged 28–56 days). HT significantly reduced feed intake, BW, and average daily gain (ADG) of broiler, but yucca improved the feed intake under HT condition. Yucca supplementation reduced (P < 0.05) the HT-induced increase in temperature of rectum and leg skin. Supplementation of yucca increased the hypothalamic mRNA expression of TRPV2, TRPV4, and TRPM8 (P < 0.05). Yucca reduced (P < 0.05) the plasma lipid oxidation product malondialdehyde (MDA), but did not affect the activities of antioxidant enzyme superoxide oxidase (SOD) and glutathione peroxidase (Gpx). Yucca did not affect the plasma neuro peptide Y (NPY), which was reduced by HT, yucca reduced circulation cholecystokinin (CCK) and hypothalamic mRNA expression of CCK. Supplementation of yucca increased the mRNA expression of both heat and cool sensing receptors. The results of the present study indicate that yucca could improve antioxidant status and attenuate the heat stress response by regulating hypothalamic temperature-sensing genes in growing chickens. Besides, yucca supplementation improved feed intake probably through modulating CCK in growing broilers under high ambient temperature.

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Central regulation of food intake in mammals and birds: a review

Cited by 7 publications

References 69 publications

Domestication and Feed Restriction Programming Organ Index, Dopamine, and Hippocampal Transcriptome Profile in Chickens

Domestication and Feed Restriction Programming Organ Index, Dopamine, and Hippocampal Transcriptome Profile in Chickens

The effect of spexin injection and its interaction with nitric oxide, serotonin, and corticotropin receptors on the central regulation of food intake in broilers

Dietary Supplementation With Yucca Alleviates Heat Stress in Growing Broilers Exposed to High Ambient Temperature

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