Central Retinal Artery Occlusion Associated with Ocular Behçet's Disease

Özdal, Pınar; Ortaç, Serap; Taşkintuna, İbrahim; Teke, Memik; Firat, Esin

doi:10.1177/112067210201200414

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Because the obliterative vasculitis seen in BD commonly affects the veins rather than the arteries, central retinal artery occlusion, that we observed in one eye, is a rare complication of the disease (23). A decrease in blood flow velocities in the central retinal artery of patients with ocular BD has been reported (24,25), but, no previous case of central retinal artery occlusion associated with BD.…”

Section: Discussionmentioning

confidence: 63%

Posterior Segment Involvement in Ocular Behçet's Disease

Ortaç

Taşkintuna

et al. 2002

European Journal of Ophthalmology

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100

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Section: Discussionmentioning

confidence: 63%

Posterior Segment Involvement in Ocular Behçet's Disease

Ortaç

Taşkintuna

et al. 2002

European Journal of Ophthalmology

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100

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“… 21 Thrombophilia commonly contributes to the development of retinal vein occlusion in patients under 50 years of age, 6 – 8 especially those without typical risk factors of hypertension, diabetes mellitus, or glaucoma. 3 , 4 , 6 , 9 , 14 , 16 Retinal artery thrombosis, when not associated with carotid artery disease, 36 Behçets disease, 37 , 38 or antiphospholipid antibody syndrome, 13 is commonly caused by familial thrombophilia and hypofibrinolysis. 2 , 4 , 9 – 13 Neither retinal vein nor artery occlusion has been reported associated with thrombophilic mutations in the thrombomodulin gene, 39 , 40 which have been associated with venous thromboembolism in Chinese.…”

Section: Discussionmentioning

confidence: 99%

Retinal artery and vein thrombotic occlusion during pregnancy: markers for familial thrombophilia and adverse pregnancy outcomes

Kurtz

Glueck

Hutchins

et al. 2016

OPTH

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BackgroundOcular vascular occlusion (OVO), first diagnosed during or immediately after giving birth, often reflects superposition of the physiologic thrombophilia of pregnancy on previously undiagnosed underlying familial or acquired thrombophilia associated with spontaneous abortion, eclampsia, or maternal thrombosis.Specific aimWe describe OVO, first diagnosed during pregnancy or immediately postpartum, in three young females (ages 32, 35, 40) associated with previously undiagnosed familial thrombophilia.ResultsBranch retinal artery occlusion (BRAO) occurred at 9 and 13 weeks gestation in two females, aged 32 and 35. Central retinal vein occlusion occurred immediately postpartum in a 40-year-old. One of the two females with BRAO subsequently developed eclampsia, and one had a history of unexplained first trimester spontaneous abortion. All three females were found to have previously unexplained familial thrombophilia. The two females with BRAO had low first trimester free protein S 42 (41%), lower normal limit (50%), and one of these two had high factor VIII (165%, upper normal limit 150%). The woman with central retinal vein occlusion had high factor XI (169%, upper normal limit 150%). Enoxaparin (40–60 mg/day) was started and continued throughout pregnancy in both females with BRAO to prevent maternal–placental thrombosis, and of these two females, one had an uncomplicated pregnancy course and term delivery, and the second was at gestational week 22 without complications at the time of this manuscript. There were no further OVO events in the two females treated with enoxaparin or in the untreated patient with postpartum eclampsia.ConclusionOVO during pregnancy may be a marker for familial or acquired thrombophilia, which confers increased thrombotic risk to the mother and pregnancy, associated with spontaneous abortion or eclampsia. OVO during pregnancy, particularly when coupled with antecedent adverse pregnancy outcomes, should prompt urgent thrombophilia evaluation and institution of thromboprophylaxis to prevent adverse maternal and fetal–placental thrombotic events.

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“…Most studies claim that thrombophilia is manifested by retinal venous occlusions, especially in patients under 50 [116][117][118], and this is especially true for people who also have the following risk factors: high blood pressure, diabetes, and glaucoma [115,116,[119][120][121][122][123]. When retinal venous occlusions cannot be explained by the presence of carotid disorders [124], antiphospholipid antibody syndrome [125], or Behcet's disease [126,127] it is important to consider hereditary thrombophilia and hypofibrinolysis [119][120][121][122][123]125,128,129].…”

Section: Pregnancy and Other Retinal Changesmentioning

confidence: 99%

A Narrative Review of the Complex Relationship between Pregnancy and Eye Changes

et al. 2021

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Pregnancy is a condition often characterized by changes that occur in different parts of the body. Generally, the eyes suffer several changes during pregnancy that are usually transient but may become permanent at times. This may occur due to the release of placental hormones and those of maternal endocrine glands and fetal adrenal glands. Due to hormonal influences, physiological ocular changes during pregnancy have been shown in Caucasian women, so corneal sensitivity, refractive status, intraocular pressure, and visual acuity may change during pregnancy. Within this review, all studies that referred to physiological aspects and to changes of ocular pathology of pregnancy, the effect of the pregnancy on pre-existing (diabetic retinopathy, neuro-ophthalmic disorders) eye disorders, postpartum ocular changes, the intraocular pressure and the effect of hypotensive ophthalmic medicine during pregnancy, the connection between pregnancy and the neuro-ophthalmic pathology, as well as the role of anesthesia were analyzed.

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Central Retinal Artery Occlusion Associated with Ocular Behçet's Disease

Cited by 12 publications

References 8 publications

Posterior Segment Involvement in Ocular Behçet's Disease

Posterior Segment Involvement in Ocular Behçet's Disease

Retinal artery and vein thrombotic occlusion during pregnancy: markers for familial thrombophilia and adverse pregnancy outcomes

A Narrative Review of the Complex Relationship between Pregnancy and Eye Changes

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