2008
DOI: 10.1016/j.taap.2007.10.004
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Central role of mitochondria and p53 in PUVA-induced apoptosis in human keratinocytes cell line NCTC-2544

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Cited by 42 publications
(47 citation statements)
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“…Adherent cells were washed three times with PBS and incubated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. MTT test was performed as previously described [23] to quantify the attached cells.…”
Section: Cell Adhesion Assaymentioning
confidence: 99%
“…Adherent cells were washed three times with PBS and incubated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. MTT test was performed as previously described [23] to quantify the attached cells.…”
Section: Cell Adhesion Assaymentioning
confidence: 99%
“…It has been shown that photoactivated psoralen (PUVA) can induce p53, ␥H2AX, and cell-cycle arrest and apoptosis (Mogi et al, 2008;Viola et al, 2008). The precise mechanism by which psoralen lesions induce these responses is not known.…”
Section: Resultsmentioning
confidence: 99%
“…However, psoralen-induced ICLs have been shown to induce DNA damage responses such as phosphorylation of the histone variant H2AX (␥H2AX) throughout the cell cycle and induce an arrest at the G 1 /S border of the cell cycle (Mogi et al, 2008;Viola et al, 2008). We and others have shown that agents that block transcription induce p53 (Yamaizumi and Sugano, 1994;Ljungman and Zhang, 1996;Ljungman and Lane, 2004) and apoptosis in human cells (Ljungman and Zhang, 1996;McKay et al, 1998;Brash et al, 2001).…”
mentioning
confidence: 99%
“…waf/Cip and p53 activation, with mitochondrial-induced cytochrome c release and the consequent apoptotic reaction [31] .…”
Section: Effects On Normal Cellsmentioning
confidence: 99%