Central Sensitization and Descending Facilitation in Chronic Pain State

Senba, Emiko; Okamoto, Keiichiro; Imbe, Hiroki

doi:10.5772/28556

Cited by 6 publications

(5 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These areas of the brain which are involved in pain sensation possess a rich serotonergic, noradrenergic, and dopaminergic innervations thus proposing the role of monoamines in pain modulation. [ 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

Preclinical screening of phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity

et al. 2015

View full text Add to dashboard Cite

Background:To discover a new agent which possesses dual property of analgesic and antimicrobial activity, thereby reducing the burden of polypharmacy. Phyllanthus amarus was screened for its analgesic and antimicrobial activities.Objectives:The objective was to evaluate the analgesic and antimicrobial activity, of P. amarus ethanolic extract (PAEE).Materials and Methods:The ethanolic extract of P. amarus was prepared using Soxhlet apparatus. An in vivo study using Swiss albino mice was done to screen the central and peripheral analgesic activity of P. amarus extract. The extract was administered at a dose of 100 mg/kg body weight orally. The peripheral analgesic activity was assessed using acetic acid induced writhing test. The central analgesic activity was assessed using Eddy's hot plate apparatus. An in vitro study was carried out to study the antimicrobial activity of the above extract using selected species of Streptococcus mutans, and S. salivarius. The antimicrobial activities were determined using the agar well method.Results:The ethanolic extract of P. amarus showed significant (P < 0.05) peripheral and central analgesic activity. In vitro antimicrobial screening indicated that the ethanolic extract had shown a zone of inhibition against S. mutans and S. salivarius in the agar wells.Conclusion:This study showed that PAEE exhibited significant analgesic and antimicrobial activities.

show abstract

Section: Discussionmentioning

confidence: 99%

Preclinical screening of phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In fact, the absence of contralateral IL-17 may reinforce the possibility that ipsilateral immune-related signaling may drive contralateral spinal cord pain neuron excitability via astrocyte-specific gap junctional communication [73,80] . Interestingly, supraspinal mechanisms such as activation of cortical areas important in pain processing, and descending facilitation from key brainstem areas may contribute in contralateral allodynia as well [97,98] . Proinflammatory cytokines in pain related brain regions are capable of impairing descending inhibitory pain pathways [99] .…”

Section: Sex Convergent and Sex Divergent Aberrant Spinal Immune Respmentioning

confidence: 99%

LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes

Noor¹,

Sun²,

Vanderwall³

et al. 2019

View full text Add to dashboard Cite

Aim: The majority of preclinical studies investigating aberrant glial-neuroimmune actions underlying neuropathic pain have focused on male rodent models. Recently, studies have shown peripheral immune cells play a more prominent role than glial cells in mediating pathological pain in females. Here, we compared the onset and duration of allodynia in males and females, and the anti-allodynic action of a potentially novel therapeutic drug (BIRT377) that not only antagonizes the action of lymphocyte function-associated antigen-1 (LFA-1) to reduce cell migration in the periphery, but may also directly alter the cellular inflammatory bias. Methods: Male and female mice were subjected to peripheral nerve injury chronic constriction injury (CCI) applying two methods, using either 4-0 or 5-0 chromic gut suture material, to examine potential sex differences in the onset, magnitude and duration of allodynia. Hindpaw sensitivity before and after CCI and application of intravenous BIRT377 was assessed. Peripheral and spinal tissues were analyzed for protein (multiplex electrochemiluminescence technology) and mRNA expression (quantitative real-time PCR). The phenotype of peripheral T cells was determined using flow cytometry. Results: Sex differences in proinflammatory CCL2 and IL-1β and the anti-inflammatory IL-10 were observed from a set of cytokines analyzed. A profound proinflammatory T cell (Th17) response in the periphery and spinal cord was also observed in neuropathic females. BIRT377 reversed pain, reduced IL-1β and TNF, and increased IL-10 and transforming growth factor (TGF)-β1, also an anti-inflammatory cytokine, in both sexes. However, female-derived T cell cytokines are transcriptionally regulated by BIRT377, as demonstrated by reducing proinflammatory IL-17A production with concurrent increases in IL-10, TGF-β1 and the anti-inflammatory regulatory T cell-related factor, FOXP3. Conclusion: This study supports that divergent peripheral immune and neuroimmune responses during neuropathy exists between males and females. Moreover, the modulatory actions of BIRT377 on T cells during neuropathy are predominantly specific to females. These data highlight the necessity of including both sexes for studying drug efficacy and mechanisms of action in preclinical studies and clinical trials.

show abstract

“…Central sensitization and descending facilitation may play important roles in the pathogenesis and maintenance of pain in functional pain syndrome or central dysfunctional pain such as fibromyalgia (FM), chronic low back pain (CBP) and temporomandibular disorder (TMD) (Senba et al, 2011). Characteristic functional connectivity of brain networks in chronic pain patients has been reported.…”

Section: Exercise-induced Changes In Functional Connectivity In the Bmentioning

confidence: 99%

A new aspect of chronic pain as a lifestyle-related disease

Senba

Kami

2017

Neurobiology of Pain

Self Cite

View full text Add to dashboard Cite

show abstract

Central Sensitization and Descending Facilitation in Chronic Pain State

Cited by 6 publications

References 118 publications

Preclinical screening of phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity

Preclinical screening of phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity

LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes

A new aspect of chronic pain as a lifestyle-related disease

Contact Info

Product

Resources

About