Central serotonin level-dependent changes in body temperature following administration of tryptophan to pargyline- and harmaline-pretreated rats

Abdel-Fattah, Abdel-Fattah Mohamed; Matsumoto, Kinzo; Murakami, Yukihisa; Gammaz, Hatim Abdel-Khalek; Mohamed, Moustafa F; Watanabe, Hiroshi

doi:10.1016/s0306-3623(96)00300-x

Cited by 34 publications

(19 citation statements)

References 9 publications

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“…The TST is used to screen antidepressant compounds or assess depression-like phenotypes (Cryan et al, 2005;Steru et al, 1985). This test was chosen particularly because it is not confounded by changes in body temperature that could result from manipulations of the 5-HT system (Abdel-Fattah et al, 1997;Sheard and Aghajanian, 1967). It is also not affected by changes in appetite that can result from treatment with cholinergic compounds (Mineur et al, 2011).…”

Section: Behavioral Assaysmentioning

confidence: 99%

Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine

Mineur

Einstein

Bentham

et al. 2014

Neuropsychopharmacol

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Nicotinic acetylcholine receptor (nAChR) blockers potentiate the effects of selective serotonin reuptake inhibitors (SSRIs) in some treatment-resistant patients; however, it is not known whether these effects are independent, or whether the two neurotransmitter systems act synergistically. We first determined that the SSRI fluoxetine and the nicotinic partial agonist cytisine have synergistic effects in a mouse model of antidepressant efficacy, whereas serotonin depletion blocked the effects of cytisine. Using a pharmacological approach, we found that the 5-HT1A agonist 8-OH-DPAT also potentiated the antidepressant-like effects of cytisine, suggesting that this subtype might mediate the interaction between the serotonergic and cholinergic systems. The 5-HT1A receptors are located both presynaptically and postsynaptically. We therefore knocked down 5-HT1A receptors in either the dorsal raphe (presynaptic autoreceptors) or the hippocampus (a brain area with high expression of 5-HT1A heteroreceptors sensitive to cholinergic effects on affective behaviors). Knockdown of 5-HT1A receptors in hippocampus, but not dorsal raphe, significantly decreased the antidepressant-like effect of cytisine. This study suggests that serotonin signaling through postsynaptic 5-HT1A receptors in the hippocampus is critical for the antidepressantlike effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders.

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Section: Behavioral Assaysmentioning

confidence: 99%

Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine

Mineur

Einstein

Bentham

et al. 2014

Neuropsychopharmacol

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“…Changes in body-core temperature (claudqcT cor ), attributable to 5-HT-mediated thermoregulation in the central nervous system (Lin et al, 1998), are a most obvious indication for the toxidrome (Isbister and Buckley, 2005). Several studies conducted in animals have revealed both hyperthermia and hypothermia in the toxidrome (Abdel-Fattah et al, 1995, 1997Nisijima et al, 2001Nisijima et al, , 2003. However, little is known about changes in body-core temperature in the context of different degrees of toxicity although in the severe state their relationship has been examined by others using a single dose protocol (Grahame-Smith, 1971b;Jacobs and Klemfuss, 1975;Nisijima et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats

Ma¹,

Zhang²,

Jenney³

et al. 2008

European Journal of Pharmacology

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Patients are at high risk of developing serotonin-toxicity syndrome (toxidrome) when they take multiple serotonergic drugs, particularly co-administered with monoamine oxidase inhibitors or 5-hydroxytryptamine (5-HT) reuptake blockers. The toxidrome can vary from mild to severe. The primary goal of the present study was to understand the relationship between behavioral signs and degrees of toxidrome induced by 5-hydroxy-L-tryptophan (5-HTP) in clorgylinized rats. The severity was obtained by scoring behavioral signs including head shakes, penile erection, forepaw treading, hind limb abduction, Straub tail and tremor. It was found that 5-HTP produced a dosedependent increase in degrees of the toxidrome. Furthermore, correlation between the toxidrome and changes in body-core temperature (claudqcT cor ) was determined. There was hypothermia in the mild toxidrome (claudqcT cor < −1 °C), high hyperthermia in the severe toxidrome (claudqcT cor > +2 °C) and a small change in T cor in the moderate toxidrome (−1 °C < claudqcT cor < +2 °C). Thus, claudqcT cor in response to drugs can be used to estimate the severity of the toxidrome. The second attempt was to identify the receptors mediating those changes. 5-HT 1A receptors were involved in the hypothermic response while 5-HT 2A and NMDA receptors mediated head shakes, hyperthermia, forepaw treading and Straub tail. Lastly, antidotal effect of cyproheptadine and (+)-MK-801 was examined. Both drugs blocked hyperthermia and death. However, the effects on mortality became poor when the antidotes were injected 60 min after high hyperthermia had been induced. These findings demonstrate the importance of the time frame using antidotes in the treatment of the 5-HT toxidrome.

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“…In vertebrates, serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a role for all important bodily functions, such as sleep [4,5], food intake, mood [6], and mammalian body temperature regulation [7][8][9]. The anatomical organization of brain serotonergic systems is remarkably conserved among vertebrates [10].…”

mentioning

confidence: 99%

Circulating serotonin in vertebrates

Maurer‐Spurej

2005

CMLS, Cell. Mol. Life Sci.

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The role of circulating serotonin is unclear and whether or not serotonin is present in the blood of non-mammalian species is not known. This study provides the first evidence for the presence of serotonin in thrombocytes of birds and three reptilian species, the endothermic leatherback sea turtle, the green sea turtle and the partially endothermic American alligator. Thrombocytes from a fresh water turtle, American bullfrog, Yellowfin tuna, and Chinook salmon did not contain serotonin. Serotonin is a vasoactive substance that regulates skin blood flow, a major mechanism for endothermic body temperature regulation, which could explain why circulating serotonin is present in warm-blooded species. The temperature sensitivity of human blood platelets with concomitant changes in serotonin content further supports a link between circulating serotonin and thermoregulation. Phylogenetic comparison of the presence of circulating serotonin indicated an evolutionary divergence within reptilian species that might coincide with the emergence of endothermy.

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Central serotonin level-dependent changes in body temperature following administration of tryptophan to pargyline- and harmaline-pretreated rats

Cited by 34 publications

References 9 publications

Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine

Expression of the 5-HT1A Serotonin Receptor in the Hippocampus Is Required for Social Stress Resilience and the Antidepressant-Like Effects Induced by the Nicotinic Partial Agonist Cytisine

Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats

Circulating serotonin in vertebrates

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