Central Vascular Thrombosis in Neonates with Congenital Heart Disease Awaiting Cardiac Intervention

Eason, Alexander J.; Crethers, Danielle; Ghosh, Santu; Stansfield, Brian K.; Polimenakos, Anastasios C.

doi:10.1007/s00246-020-02383-2

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Though children with unplanned surgical reintervention and MCS both have disruptions of blood flow and cytokine release, the difference in risk could be explained by the routine use of anticoagulation in MCS. Eason et al [24] found that children with single ventricle anatomy were at higher risk for CADVT than children with biventricular anatomy, perhaps because of the former requiring more frequent surgeries and invasive monitoring, or having a higher prothrombotic predisposition.…”

Section: Risk Factors For Central Venous Catheter-associated Deep Vei...mentioning

confidence: 99%

Central venous catheter-associated deep vein thrombosis in critically ill pediatric patients: risk factors, prevention, and treatment

Johnson

Faustino

2022

Current Opinion in Pediatrics

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Purpose of review Central venous catheter (CVC) placement and ICU admission are the two most important risk factors for pediatric deep vein thrombosis. The optimal prevention and treatment strategies for CVC-associated deep vein thrombosis (CADVT) are unclear, but recently, seminal studies have been published. This review aims to summarize the recent literature on CADVT in critically ill children. Recent findings Recent publications focused on three themes: risk factors, prevention, and treatment of CADVT. Newly identified risk factors for CADVT relate to Virchow's triad of hemostasis, blood vessel injury, and hypercoagulability. New risk prediction models have moderately good accuracy in predicting CADVT. Though previous data on pharmacologic CADVT prophylaxis was equivocal, recent studies indicate that low-molecular-weight heparin may be effective in preventing CADVT, particularly in critically ill children. Finally, new studies suggest that direct oral anticoagulants and shorter treatment times are noninferior to traditional agents and treatment durations in the treatment of CADVT. Summary Recent research suggests new ways to accurately identify children at high risk of CADVT, effectively prevent CADVT, and optimize CADVT treatment. Future research should focus on understanding the pathobiology of CADVT formation, prevention, and treatment in critically ill children.

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Section: Risk Factors For Central Venous Catheter-associated Deep Vei...mentioning

confidence: 99%