Central Vein Catheter-Related Thrombosis in Intensive Care Patients

Timsit, Jean‐François; Farkas, Jean-Christophe; Boyer, Jean-Marc; Martin, J.; Misset, Benoît; Renaud, Bertrand; Carlet, Jean

doi:10.1378/chest.114.1.207

Cited by 423 publications

(96 citation statements)

References 25 publications

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“…Previous studies described a relationship between the number of CRBSI and occlusions, possibly due to infection-induced activation of the coagulation system [28]. In the same vein, the decrease in catheter related occlusions in our study may be the result of diminished vascular damage because of the lower infection rate [28]. In contrast, the earlier mentioned meta-analysis (with its described limitations) found no significant difference between taurolidine and heparin-treated CVCs in incidence of catheter occlusions [20].…”

Section: Discussioncontrasting

confidence: 69%

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Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

et al. 2014

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Background and AimsPatients on home parenteral nutrition (HPN) are at risk for catheter-related complications; mainly infections and occlusions. We have previously shown in HPN patients presenting with catheter sepsis that catheter locking with taurolidine dramatically reduced re-infections when compared with heparin. Our HPN population therefore switched from heparin to taurolidine in 2008. The aim of the present study was to compare long-term effects of this catheter lock strategy on the occurrence of catheter-related bloodstream infections and occlusions in HPN patients.MethodsData of catheter-related complications were retrospectively collected from 212 patients who received HPN between January 2000 and November 2011, comprising 545 and 200 catheters during catheter lock therapy with heparin and taurolidine, respectively. We evaluated catheter-related bloodstream infection and occlusion incidence rates using Poisson-normal regression analysis. Incidence rate ratios were calculated by dividing incidence rates of heparin by those of taurolidine, adjusting for underlying disease, use of anticoagulants or immune suppressives, frequency of HPN/fluid administration, composition of infusion fluids, and duration of HPN/fluid use before catheter creation.ResultsBloodstream infection incidence rates were 1.1/year for heparin and 0.2/year for taurolidine locked catheters. Occlusion incidence rates were 0.2/year for heparin and 0.1/year for taurolidine locked catheters. Adjusted incidence ratios of heparin compared to taurolidine were 5.9 (95% confidence interval, 3.9–8.7) for bloodstream infections and 1.9 (95% confidence interval, 1.1–3.1) for occlusions.ConclusionsGiven that no other procedural changes than the catheter lock strategy were implemented during the observation period, these data strongly suggest that taurolidine decreases catheter-related bloodstream infections and occlusions in HPN patients compared with heparin.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionsupporting

confidence: 69%

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

et al. 2014

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“…This observation is consistent with the anticoagulant and antibacterial (31,34,35) activity across a broad spectrum of microbes. Of note, thrombosis and bacterial growth within biofilm are closely related in the physiopathology of catheter-related infections (36).…”

Section: Discussionmentioning

confidence: 99%

Quasi-Experimental Study of Sodium Citrate Locks and the Risk of Acute Hemodialysis Catheter Infection among Critically Ill Patients

Parienti

Deryckere

Mégarbane

et al. 2014

Antimicrob Agents Chemother

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“…The morbidity and mortality ranges from 15–50% and are statistically equivalent to lower extremity deep vein thrombosis [3, 4]. Post-thrombotic syndrome occurrence with DVT of the arm may be as high as one out of every three patients [5–7]. …”

Section: Introductionmentioning

confidence: 99%

Surface modification of a polyethylene film for anticoagulant and antimicrobial catheter

Zheng

Miao

Zhang

et al. 2016

Reactive and Functional Polymers

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A functional anticoagulant and anti-bacterial coating for polyethylene (PE) films is described. The stepwise preparation of this nanocomposite surface coating involves O2 plasma etching of PE film, carbodiimide coupling of cysteamine to the etched PE film, binding of Ag to sulfhydryl groups of cysteamine, and assembly of heparin capped AgNPs on the PE film. The nanocomposite film and its components were characterized by 1H-nuclear magnetic resonance spectroscopy, attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and field emission-scanning electron microscopy. The resulting PE films demonstrate anticoagulant activity using a hemoglobin whole blood clotting assay, and anti-bacterial activity against Bacillus cereus 3551 (Gram-positive) and Escherichia coli BL21 (Gram-negative) bacteria. The hydrophilicity of the heparin coated PE was determined by contact angle measurements; and the stability of the nanocomposite film, with respect to Ag leaching, was assessed by atomic absorption spectroscopy.

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Central Vein Catheter-Related Thrombosis in Intensive Care Patients

Cited by 423 publications

References 25 publications

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

Quasi-Experimental Study of Sodium Citrate Locks and the Risk of Acute Hemodialysis Catheter Infection among Critically Ill Patients

Surface modification of a polyethylene film for anticoagulant and antimicrobial catheter

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