Central venous catheter-related bacteraemia in critically ill neonates: risk factors and impact of a prevention programme

Maas, Axel; Flament, P; Pardou, Anne; Deplano, Ariane; Dramaix, M.; Struelens, Marc

doi:10.1016/s0195-6701(98)90139-6

Cited by 64 publications

(23 citation statements)

References 35 publications

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“…These results were concordant with the data of other publications. [13][14][15][16][17] This was in contrast, to the data reported in the NHSN report in which the CRBSI ranged from 3.1-6.4 per 1,000 CVC days. 18 This high rate could be related to increased number of VLBW of our studied group who needed frequent handling and mechanical ventilation.…”

Section: Discussioncontrasting

confidence: 79%

Central venous catheter-related blood stream infections in neonatal care unit

Badr

Hammad

Salama

et al. 2013

Int. j. infect. control

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The aim of this study was to detect the rate of catheter-related bloodstream infection (CRBSI) in NICU of Mansoura University Children's Hospital and to focus on possible predictors of infection. A cross sectional comparative study was performed to detect the rate of CRBSI among neonates with central vascular catheters during the period between January 2009 and April 2012. Then, a nested case control study done among CRBSI cases and central vascular catheters none infected as a control group to detect predictors associated with their occurrence. Blood samples were collected from 111 neonates clinically suspected of septicemia and had inserted venous line. Central, peripheral blood and catheter tip cultures were done for each case.CRBSI was confirmed in 69 cases as central blood culture count was more than 3 folds of peripheral blood culture count. Catheter tip culture showed more than 103 CFU/ ml per catheter of the same organisms. Low birth weight, age below 7 days, prematurity, mechanical ventilation, TPN administration and prolonged catheter stay were predictors of CRBSI. Logistic regression of the studied predictors showed that birth weight, TPN administration and length of central venous catheter stay were significant predictors of CRBSI. CRBSI is a common problem in NICU. Predictors of CRBSI included low birth weight, prematurity and mechanical ventilation. Potential use of TPN, prolonged catheter stay and low birth weight are independent predictors for CRBSI.

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Section: Discussioncontrasting

confidence: 79%

Central venous catheter-related blood stream infections in neonatal care unit

Badr

Hammad

Salama

et al. 2013

Int. j. infect. control

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“…surgical ICUs, neonatological ICUs, and hospital-wide. The authors of all these studies performed a surveillance with feedback and education programs [15][16][17][18][19][20][21]. Reduction rates of 41% to 100% in CA-BSIs were discussed in further studies [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Surveillance with successful reduction of central line-associated bloodstream infections among neutropenic patients with hematologic or oncologic malignancies

et al. 2009

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“…Without stratification, the heterogeneity of the study population could render comparisons between units, or over time in a single unit, invalid or misleading. For example, stratification by birth weight categories is recommended for NICU patients, because low birth weight has proved to be a significant risk factor for HAIs [10,11,64,74,76,79,80,194].…”

Section: Purpose and Objectives Of Surveillancementioning

confidence: 99%

“…Similar findings have also been reported from single NICUs. The introduction of a prevention program in an NICU in Belgium yielded a 71% RR reduction for CVC-related BSIs over a four-year period [194]. In an NICU in Pittsburgh, USA, improving CVC care practices decreased RR for a CVC-related BSI by 37% [226]; similar interventions led to a 55% RR reduction for all HAIs in an NICU in Singapore [227].…”

Section: Surveillance Feedbackmentioning

confidence: 99%

“…Such stories have also been reported from NICUs [194,224]. Within SIRO, continuously updated surveillance data are available through the project web site; each hospital has access to its own data (both hospital-wide and on the ward level) as well as the aggregated data, which are also presented at annual SIRO meetings.…”

Section: Surveillance Of Bloodstream Infections (I)mentioning

confidence: 99%

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314 Healthcare-Associated Infections in Pediatrics

SpringerReference

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Helsinki 2008 P u b l i c a t i o n s o f t h e N a t i o n a l P u b l i c H e a l t h I n s t i t u t e K T L A 1 1 / 2 0 0 8 Dr. Alexander Langmuir, 1963 Emmi Sarvikivi, Healthcare-associated infections in pediatrics Publications of the National Public Health Institute, A11/2008, 93 Pages ISBN 978-951-740-803-5; 978-951-740-804-2 (pdf-version) ISSN 0359-3584; 1458-6290 (pdf-version) http://www.ktl.fi/portal/4043 ABSTRACT Background and aims. Healthcare-associated infections (HAIs) are known to increase the risk for patient morbidity and mortality in different healthcare settings and thereby to cause additional costs. HAIs typically affect patients with severe underlying conditions, such as patients treated in intensive care units, or patients who have undergone medical procedures, e.g., surgery. HAIs are prevalent also among pediatric patients, but the distribution of the types of infection and the causative agents differ from those detected in adults. The aim of this study was to obtain information on pediatric HAIs in Finland through an assessment of the surveillance of bloodstream infections (BSIs), through two outbreak investigations in a neonatal intensive care unit (NICU), and through a study of postoperative HAIs after open-heart surgery.Methods. The Hospital for Children and Adolescents of the Helsinki University Central Hospital has participated in the BSI surveillance of the Finnish Hospital Infection Program since 1999. These data were utilized in all studies. The epidemiological features of pediatric BSIs were assessed. For the outbreak investigations, case definitions were set and data collected from microbiological and clinical records. The antimicrobial susceptibilities of the Serratia marcescens and the Candida parapsilosis isolates were determined. The S. marcescens isolates were genotyped with pulsed-field gel electrophoresis and the C. parapsilosis blood culture isolates (obtained between the years 1990 and 2002) with Southern blot hybridization by use of a DNA fingerprinting probe. Patient charts were reviewed for the case-control and cohort studies during the outbreak investigations, as well as for those patients who acquired surgical site infections (SSIs) after having undergone open-heart surgery. Also a prospective postdischarge study was conducted to detect postoperative HAIs after open-heart surgery.Results. During 1999During -2006, the overall annual BSI rate was 1.6/1,000 patient-days (range by year, 1.2-2.1). High rates (average, 4.9 and 3.2 BSIs/1,000 patient-days) were detected in hematology and neonatology units. Coagulase-negative staphylococci were the most common pathogens both hospital-wide and in each patient group. The overall mortality was 5%. The genotyping of the 15 S. marcescens isolates revealed three independent clusters. All of the 26 C. parapsilosis isolates studied proved to be indistinguishable. No common source was identified for either of the outbreaks, but the NICU was overcrowded during the S. marcescens clusters. In both investigations, low birth we...

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Central venous catheter-related bacteraemia in critically ill neonates: risk factors and impact of a prevention programme

Cited by 64 publications

References 35 publications

Central venous catheter-related blood stream infections in neonatal care unit

Central venous catheter-related blood stream infections in neonatal care unit

Surveillance with successful reduction of central line-associated bloodstream infections among neutropenic patients with hematologic or oncologic malignancies

314 Healthcare-Associated Infections in Pediatrics

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