Central vestibular networks in the guinea-pig: functional characterization in the isolated whole brain in vitro

Babalian, A.; Vibert, Nicolas; Assie, G.; Serafin, Mauro; Mühlethaler, Michel; Vidal, Pierre‐Paul

doi:10.1016/s0306-4522(97)00069-9

Cited by 80 publications

(75 citation statements)

References 56 publications

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“…There was an apparent discrepancy between the higher sensitivity of the ipsilesional type B MVNn to ramp-like and sinusoidal currents and the increase of their AHP, which should make them less sensitive to current changes. However, while the increased AHP must give type B MVNn a greater stability and smaller sensitivity to small, random synaptic noise (see Babalian et al 1997), it did not apparently alter their sensitivity to high-amplitude ramplike and sinusoidal potential modulations that reach 5-10 mV or more in most cases.…”

Section: Functional Implications Of the Long-term Changes Of The Membmentioning

confidence: 92%

“…In contrast, only 66% of the type B neurons and 33% of all MVNn display a double AHP at rest in the guinea pig. Altogether, rat and mice seem to have more phasic MVNn and less tonic neurons than guinea pigs (see Babalian et al 1997 for the equivalence between the in vitro and in vivo classifications of MVNn). This difference may be linked to the different ecological niches of these species.…”

Section: Categorization Of Mvnnmentioning

confidence: 99%

“…All this could increase in vivo the stability of the spontaneous discharge recovered by the deafferented MVNn. Indeed, bigger AHPs should limit the sensitivity of MVNn to small amplitude synaptic inputs, as shown by Babalian et al (1997). Stability of the spontaneous discharge is probably an essential requirement for a proper functioning of the vestibular system, and suppression of the labyrinthine afferents generates instability in central vestibular networks.…”

Section: Functional Implications Of the Long-term Changes Of The Membmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Plasticity of Ipsilesional Medial Vestibular Nucleus Neurons After Unilateral Labyrinthectomy

Beraneck

Hachemaoui²,

Idoux³

et al. 2003

Journal of Neurophysiology

109

142

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. Long-term plasticity of ipsilesional medial vestibular nucleus neurons after unilateral labyrinthectomy. J Neurophysiol 90: 184 -203, 2003. First published March 20, 2003 10.1152/jn.01140.2002. Unilateral labyrinthectomy results in oculomotor and postural disturbances that regress in a few days during vestibular compensation. The long-term (after 1 mo) consequences of unilateral labyrinthectomy were investigated by characterizing the static and dynamic membrane properties of the ipsilesional vestibular neurons recorded intracellularly in guinea pig brain stem slices. We compared the responses of type A and type B medial vestibular nucleus neurons identified in vitro to current steps and ramps and to sinusoidal currents of various frequencies. All ipsilesional vestibular neurons were depolarized by 6 -10 mV at rest compared with the cells recorded from control slices. Both their average membrane potential and firing threshold were more depolarized, which suggests that changes in active conductances compensated for the loss of excitatory afferents. The afterhyperpolarization and discharge regularity of type B but not type A neurons were increased. All ipsilesional vestibular cells became more sensitive to current injections over a large range of frequencies (0.2-30 Hz), but this increase in sensitivity was greater for type B than for type A neurons. This was associated with an increase of the peak frequency of linear response restricted to type B neurons, from 4 -6 to 12-14 Hz. Altogether, we show that long-term vestibular compensation involves major changes in the membrane properties of vestibular neurons on the deafferented side. Many of the static and dynamic membrane properties of type B neurons became more similar to those of type A neurons than in control slices, leading to an increase in the overall homogeneity of medial vestibular nucleus neurons.

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Section: Functional Implications Of the Long-term Changes Of The Membmentioning

confidence: 92%

Section: Categorization Of Mvnnmentioning

confidence: 99%

Section: Functional Implications Of the Long-term Changes Of The Membmentioning

confidence: 99%

See 1 more Smart Citation

Long-Term Plasticity of Ipsilesional Medial Vestibular Nucleus Neurons After Unilateral Labyrinthectomy

Beraneck

Hachemaoui²,

Idoux³

et al. 2003

Journal of Neurophysiology

109

142

View full text Add to dashboard Cite

show abstract

“…The responses with shortest latencies of 3.2-3.5 ms were EPSPs recorded in two radiate stellate cells of the AVCN. In the IWB preparation, these latency values most likely correspond to disynaptic transmission (Babalian et al 1997(Babalian et al , 1999(Babalian et al , 2002. As both the AVCN cells extended their dendrites to the GCD and the PN input to GCD was shown to be excitatory (Ohlrogge et al 2001), the most probable mechanism of observed disynaptic EPSPs would be an excitation of the granule cells by PN projections and following excitatory action from granule cells to target cells.…”

Section: Discussionmentioning

confidence: 92%

“…The methods used to prepare and maintain the IWB preparation in vitro were similar to those described in detail previously (Babalian et al 1997). Briefly, the guinea pigs were anesthetized with a lethal dose of pentobarbital (150-300 mg/kg, i.p.)…”

Section: Methodsmentioning

confidence: 99%

Synaptic influences of pontine nuclei on cochlear nucleus cells

Babalian

2005

Exp Brain Res

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Using the in vitro isolated whole brain preparation of the guinea pig, we tested the synaptic effects induced by the stimulation of pontine nuclei (PN) in intracellularly recorded and stained principal cells of the cochlear nucleus (CN). Twenty percent of the recorded cells in all CN subdivisions responded to stimulation of either ipsilateral or contralateral PN, and 12% of the cells exhibited convergence of inputs from both sides. The responses were recorded only in stellate cells of the ventral CN and in the pyramidal cells of the dorsal CN, whereas no responses were observed in bushy, octopus, and giant cells. PN stimulation produced excitatory and inhibitory postsynaptic potentials as well as mixed responses. The heterogeneous nature and the wide latency range (3.2-18 ms) of observed responses suggest significant variability in the underlying synaptic mechanisms and the implicated pathways. We propose that PN projections to the CN, terminating mainly in the granule cell domain (GCD), together with other non-auditory and auditory inputs contribute to multimodal convergence in the GCD leading ultimately to modulatory actions on the output activity of CN principal cells.

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Stochastic and sinusoidal electrical stimuli increase the irregularity and gain of Type A and B medial vestibular nucleus neurons, in vitro

Stefani

Pastras

Serrador

et al. 2021

J of Neuroscience Research

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Galvanic vestibular stimulation (GVS) has been shown to improve vestibular function potentially via stochastic resonance, however, it remains unknown how central vestibular nuclei process these signals. In vivo work applying electrical stimuli to the vestibular apparatus of animals has shown changes in neuronal discharge at the level of the primary vestibular afferents and hair cells. This study aimed to determine the cellular impacts of stochastic, sinusoidal, and stochastic + sinusoidal stimuli on individual medial vestibular nucleus (MVN) neurons of male and female C57BL/6 mice. All stimuli increased the irregularity of MVN neuronal discharge, while differentially affecting neuronal gain. This suggests that the heterogeneous MVN neuronal population (marked by differential expression of ion channels), may influence the impact of electrical stimuli on neuronal discharge. Neuronal subtypes showed increased variability of neuronal firing, where Type A and B neurons experienced the largest gain changes in response to stochastic and sinusoidal stimuli. Type C neurons were the least affected regarding neuronal firing variability and gain changes. The membrane potential (MP) of neurons was altered by sinusoidal and stochastic + sinusoidal stimuli, with Type B and C neuronal MP significantly affected. These results indicate that GVS‐like electrical stimuli impact MVN neuronal discharge differentially, likely as a result of heterogeneous ion channel expression.

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Central vestibular networks in the guinea-pig: functional characterization in the isolated whole brain in vitro

Cited by 80 publications

References 56 publications

Long-Term Plasticity of Ipsilesional Medial Vestibular Nucleus Neurons After Unilateral Labyrinthectomy

Long-Term Plasticity of Ipsilesional Medial Vestibular Nucleus Neurons After Unilateral Labyrinthectomy

Synaptic influences of pontine nuclei on cochlear nucleus cells

Stochastic and sinusoidal electrical stimuli increase the irregularity and gain of Type A and B medial vestibular nucleus neurons, in vitro

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