Central visfatin causes orexigenic effects in chicks

Cline, Mark A.; Nandar, Wint; Prall, Brian C.; Bowden, Christie; Denbow, D. Michael

doi:10.1016/j.bbr.2007.08.016

Cited by 49 publications

(21 citation statements)

References 23 publications

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“…Recent research demonstrated that several adipokines affect food intake in chicks. For example, central administration of visfatin significantly increased food intake in broiler chicks (Cline et al, 2008). Yabuuchi et al (2010) reported that agouti signaling protein, an endogenous melanocortin-4 receptor antagonist, was expressed in chicken adipose tissue.…”

Section: Resultsmentioning

confidence: 99%

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

et al. 2013

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Lines of evidence suggest that hypothalamic neuropeptides have a physiological role in the regulation of food intake in mammals. However, little is known about the age-dependent change of hypothalamic neuropeptides in chicks. In this study, we investigated the age-dependent changes in hypothalamic mRNA levels of neuropeptide Y (NPY, an orexigenic neuropeptide), proopiomelanocortin (POMC, the precursor of anorexigenic neuropeptides), and corticotropin-releasing factor (CRF, a possible mediator in the POMC-induced anorexigenic pathway) in growing broiler chicks. The weights of body and abdominal adipose tissue of chicks were measured at 7, 14, 21, and 28 days of age, and the hypothalamic mRNA levels of NPY, POMC, and CRF were analyzed by real-time PCR. Hypothalamic NPY mRNA levels at 14 and 28 days of age were significantly (P＜0.05) lower than that at 7 days of age. Hypothalamic POMC mRNA level at 28 days of age was significantly lower than that at 7 days of age. Hypothalamic CRF mRNA level was not affected throughout the experimental period. Abdominal adipose tissue weight was significantly increased after 14 days of age in chicks. Our findings demonstrated that the expressions of NPY and POMC are dependent on age in boiler chicken hypothalamus.

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Section: Resultsmentioning

confidence: 99%

Age-Dependent Changes in the mRNA Levels of Neuropeptide Y, Proopiomelanocortin, and Corticotropin-Releasing Factor in the Hypothalamus in Growing Broiler Chicks

et al. 2013

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“…101 A role for NAMPT in the regulation of food intake and behaviour was demonstrated in two different animal models. 102,103 Intracerebroventricular injection of eNAMPT caused increased feed intake and pecking efficiency in chicks, 102 whereas injection of eNAMPT into the arcuate nucleus of the hypothalamus of rats increased food intake and reduced hypothalamic expression of anorexigenic peptides. 103 A 2015 study indicated that eNAMPT secreted by adipose tissue influences hypothalamic function.…”

Section: Pathophysiological Role Of Namptmentioning

confidence: 99%

Physiological and pathophysiological roles of NAMPT and NAD metabolism

et al. 2015

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Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent enzymes. In various metabolic disorders and during ageing, levels of NAD are decreased. Through its NAD-biosynthetic activity, NAMPT influences the activity of NAD-dependent enzymes, thereby regulating cellular metabolism. In addition to its enzymatic function, extracellular NAMPT (eNAMPT) has cytokine-like activity. Abnormal levels of eNAMPT are associated with various metabolic disorders. NAMPT is able to modulate processes involved in the pathogenesis of obesity and related disorders such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance. NAMPT also has a crucial role in cancer cell metabolism, is often overexpressed in tumour tissues and is an experimental target for antitumour therapies. In this Review, we discuss current understanding of the functions of NAMPT and highlight progress made in identifying the physiological role of NAMPT and its relevance in various human diseases and conditions, such as obesity, NAFLD, T2DM, cancer and ageing.

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“…For neuropeptide Y, one of the most studied orexigenic factors, a dose as low as 0.05 nmol is efficacious [16], visfatin, 0.025 nmol [17]; gonadotropin-inhibiting hormone, 0.9 nmol [18]; galanin, 0.3 nmol [19]; kyotorphin, 0.6 nmol [20]; and for prolactin-releasing peptide 0.375 nmol is effective [21], while 1.0 nmol was required for XPN. This may stem from a lack of understanding if the peptide is endogenous in chick and to what receptors, and their location, it binds to exert its effect.…”

Section: Discussionmentioning

confidence: 98%