As a key region for the origin and development of Chinese civilization, the relationship between the Holocene environment and human culture in the Luoyang area has garnered significant attention. However, the lack of long-term and multi-factor studies impedes our understanding of the overall characteristics of environmental systems and their interactions with human cultures. Based on extensive field investigations, we conducted a comprehensive study of the BZ profile, which exhibits continuous sedimentation and abundant paleoenvironmental information. The Holocene evolution of climate, deposition, hydrology, and landforms was analyzed, and the human-environment interaction was also examined. The findings demonstrate that the regional Holocene climate also exhibits fluctuations, albeit within a relatively narrow range. The regional sediment was predominantly composed of aeolian loess-paleosols during the early to middle Holocene, while the process of alluviation gradually intensified in the late Holocene. The moderate climatic fluctuations have facilitated the sustainable development of ancient cultures. The intensification of anthropogenic activities may contribute to the increased alluviation during the late Holocene. Ancient humans effectively adapted to this adverse condition by constructing city walls with flood control functions. Our study is significant for enhancing the comprehension of the operational characteristics inherent in human ecological systems.