Centralized radiation oncologic review of cross-sectional imaging of Hodgkin's disease leads to significant changes in required involved field—results of a quality assurance program of the German Hodgkin Study Group

Eich, Hans Theodor; Staar, Susanne; Goßmann, Axel; Hansemann, K.; Skripnitchenko, R.; Köcher, Martin; Semrau, R.; Engert, Andreas; Josting, Andreas; Franklin, Jeremy; Krug, Barbara; Diehl, Volker; Müller, Rolf-Peter

doi:10.1016/j.ijrobp.2003.08.033

Cited by 47 publications

(29 citation statements)

References 16 publications

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“…As described extensively in a previous report from 2004 [6] and as the outcome of former studies and investigations [2,3,4] also showed, the QA program procedure is one of the main keys to maintain treatment quality at its highest standards. Therefore, the panel of radiologists and radiation oncologists proceeded in nearly the same way as before in order to have an adequate comparison between this trial generation and the previous one in terms of the diagnostic procedure.…”

Section: Qa Program Proceduresmentioning

confidence: 80%

“…At the reference center, the imaging data were reviewed by a panel consisting of expert radiation oncologists and radiologists and compared to the documentation on the CRFs. To ensure consistency between the reference center and the local center, this procedure and definitions were extensively described in the written study protocol [6]. The individual site, extent, and spread of disease was marked in a schematic figure and an individual IF-RT treatment field was provided for each study patient [6].…”

Section: Qa Program Proceduresmentioning

confidence: 99%

“…To ensure consistency between the reference center and the local center, this procedure and definitions were extensively described in the written study protocol [6]. The individual site, extent, and spread of disease was marked in a schematic figure and an individual IF-RT treatment field was provided for each study patient [6]. The definition of the IF-RT treatment fields was the same as in the previous studies HD10/11 which is extensively described in the study protocol.…”

Section: Qa Program Proceduresmentioning

confidence: 99%

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Quality control of involved-field radiotherapy for patients with early stage Hodgkin’s lymphoma based on a central prospective review

et al. 2012

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Section: Qa Program Proceduresmentioning

confidence: 80%

Section: Qa Program Proceduresmentioning

confidence: 99%

Section: Qa Program Proceduresmentioning

confidence: 99%

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Quality control of involved-field radiotherapy for patients with early stage Hodgkin’s lymphoma based on a central prospective review

et al. 2012

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“…To ensure that IF-radiotherapy was performed exactly according to the RTprescriptions of the protocol, an extensive quality assurance program was performed. A prospective radiotherapy planning by the radiotherapy reference centre in Cologne on the basis of clinical and laboratory data as well as on the basis of all pre-treatment diagnostic imaging was initiated [14]. The recent final analysis of this large trial showed that the reduction of chemotherapy is possible and that there was no difference between the different radiation doses [15].…”

Section: Clinical Results In Early-favourable Stages From a Single Ramentioning

confidence: 99%

Radiotherapy in Early-Stage Favourable Hodgkin`s Lymphom: Experiences of the German Hodgkin Study Group

Müller¹,

Eich²

2010

TOPROCJ

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Since its beginning, more than 15.000 patients with Hodgkin's lymphoma (HL) have been enrolled into the multicentre randomized trials of the German Hodgkin Study Group (GHSG). Within 4 study generations the treatment of HL has been developed stepwise by using the results of the completed protocols. According to radiotherapy, the study group successfully evaluated different dose-effect relationships and could also prove the efficacy of involved field radiotherapy in early stages in combination with effective chemotherapy. According to the recent final analysis of the HD10 trial for patients with early-favourable HL, a radiation dose of 20 Gy to the involved lymph node areas preceded by short-term chemotherapy (ABVD x 2) is the standard for these patients. An extensive radiotherapy quality assurance program, performed by the GHSG radiotherapy reference centre in Cologne, has proven to be successful and necessary to ensure that with reduced radiation doses and volumes a precise treatment, as defined by the protocol, can be performed by the participating radiotherapy departments.

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“…PET helps to distinguish complete disease remission from partial response (Eich et al, 2004; which can lead to a change in treatment plan. FDG-PET is very valuable for radiotherapy purpose.…”

Section: Therapy For Lymphomamentioning

confidence: 99%

Importance of PET/CT Scan Use in Planning Radiation Therapy for Lymphoma

Mitric-Askovic

Erak²,

Latinovic³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Radiation therapy is a key part of the combined modality treatment for Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), which can achieve locoregional control of disease. The 3D-conformal radiation oncology can be extended-field (EFRT), involved-field (IFRT) and involved node (INRT). New techniques have resulted in a smaller radiation field and lower dose for critical organs such as lung heart and breast. Materials and Methods: In our research, we made a virtual simulation for one patient who was treated in four different radiotherapeutic techniques: mantle field (MFRT), EFRT, IFRT and INRT. After delineatiion we compared dose-volume histograms for each technique. The fusion of CT for planning radiotherapy with the initial PET/CT was made using Softver Xio 4.6 in the Focal program. The dose for all four techniques was 36Gy. Results: Our results support the use of PET/CT in radiation therapy planning. With IFRT and INRT, the burden on the organs at risk is less than with MFRT and EFRT. On the other hand, the dose distribution in the target volume is much better with the latter. Conclusions: The aim of modern radiotherapy of HL and NHL is to reduce the intensity of treatment and therefore PET/CT should be used to reduce and not increase the amount of tissue receiving radiation.

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Centralized radiation oncologic review of cross-sectional imaging of Hodgkin's disease leads to significant changes in required involved field—results of a quality assurance program of the German Hodgkin Study Group

Cited by 47 publications

References 16 publications

Quality control of involved-field radiotherapy for patients with early stage Hodgkin’s lymphoma based on a central prospective review

Quality control of involved-field radiotherapy for patients with early stage Hodgkin’s lymphoma based on a central prospective review

Radiotherapy in Early-Stage Favourable Hodgkin`s Lymphom: Experiences of the German Hodgkin Study Group

Importance of PET/CT Scan Use in Planning Radiation Therapy for Lymphoma

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