Centrally administered PD 140.548 N-methyl-d-glucamine prevents the autonomic responses to duodenal pain in sheep

Kania, B.F.; Kania, Kinga; Romanowicz, Katarzyna; Tomaszewska, D.; Šutiak, V.; Wronska‐Fortuna, D.

doi:10.1016/j.rvsc.2005.09.002

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…Teeth grinding increases in frequency with experimental induction of visceral pain, alongside increases in plasma cortisol, heart rate, hyperventilation, and other clinical and behavioral signs of pain ( 84 ), and is seen in painful disease conditions [e.g., ruminal acidosis ( 85 )]. The frequency of tooth grinding does not appear to have been included in on-farm welfare assessments before, thus reliability has not been tested.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Animal-Based Indicators to Be Used in a Welfare Assessment Protocol for Sheep

et al. 2017

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Sheep are managed under a variety of different environments (continually outdoors, partially outdoors with seasonal or diurnal variation, continuously indoors) and for different purposes, which makes assessing welfare challenging. This diversity means that resource-based indicators are not particularly useful and, thus, a welfare assessment scheme for sheep, focusing on animal-based indicators, was developed. We focus specifically on ewes, as the most numerous group of sheep present on farm, although many of the indicators may also have relevance to adult male sheep. Using the Welfare Quality® framework of four Principles and 12 Criteria, we considered the validity, reliability, and feasibility of 46 putative animal-based indicators derived from the literature for these criteria. Where animal-based indicators were potentially unreliably or were not considered feasible, we also considered the resource-based indicators of access to water, stocking density, and floor slipperiness. With the exception of the criteria “Absence of prolonged thirst,” we suggest at least one animal-based indicator for each welfare criterion. As a minimum, face validity was available for all indicators; however, for many, we found evidence of convergent validity and discriminant validity (e.g., lameness as measured by gait score, body condition score). The reliability of most of the physical and health measures has been tested in the field and found to be appropriate for use in welfare assessment. However, for the majority of the proposed behavioral indicators (lying synchrony, social withdrawal, postures associated with pain, vocalizations, stereotypy, vigilance, response to surprise, and human approach test), this still needs to be tested. In conclusion, the comprehensive assessment of sheep welfare through largely animal-based measures is supported by the literature through the use of indicators focusing on specific aspects of sheep biology. Further work is required for some indicators to ensure that measures are reliable when used in commercial settings.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Animal-Based Indicators to Be Used in a Welfare Assessment Protocol for Sheep

et al. 2017

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“…The experiment was performed on 12 mature crossbred ewes, 10 . Animals had free access to hay and water, except during the experimental period.…”

Section: Preparation Of Animalsmentioning

confidence: 99%

Central Glutaminergic Influences on Viscero-visceral Inhibitory Reflex During Colonal Descending Distension in Ovine Model

Kania

Wrońska²

2016

PBJ

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The aim of presented study was to examine the participation of group I metabotropic glutamate receptors (mGluRs) in development and maintenence reticulo-ruminal motility inhibition caused by visceral pain caused by colonic distension (CD) of different degrees provoked in ovine. Motility inhibition was qualified as a vegetative symptom of the nocifensive effects (viscero-visceral inhibitory reflex). The experiment was carried out on 12 female sheep, Polish merino, in the anoestrus period. A five min CD episode provokes a statistically significant reticulo-ruminal motility inhibition. Intracerebroventriculary (i.c.v.) administration of the group I mGluRs antagonist DL-AP3 10 min prior to CD, prevents the visceral pain development. Practically all pain symptoms were easy to observe and quantify. These symptoms were recurrently appearing in animals suffering colon distension; however, the intensity was smaller than in the case of duodenal distension. It suggests that this model of colic is not only less invasive but also less painful for animals. In conclusion, the development and maintenance of reticulo-ruminal motor inhibition of colonic distension are dependent on group I mGluRs receptor activation in the CNS and that these receptors play a crucial role in modulating the acute colonic pain (experimental colic). This less invasive in vivo method may be useful for testing the efficacy of potentially analgesic xenobiotics in small ruminants.

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“…They conclude that the CCK1R antagonist PD-140,548, but not the CCK1R agonist A-71623, enhanced LI in the rat, suggesting that the inhibition of CCK activity might constitute a new promising strategy for the pharmacological treatment of schizophrenia [38]. In addition, Kania and co-workers showed that the CCK1 antagonist PD-140,548 can be an effective analgesic agent in duodenal pain, and that this action is due to the inhibition of CCK1 receptors in the central descending nerve pathway, probably via the hypothalamic-pituitary-adrenal axis [39,40].…”

Section: Dipeptoids and Restricted Derivativesmentioning

confidence: 99%

Strategies for Design of Non Peptide CCK1R Agonist/Antagonist Ligands

García-López¹,

González‐Muñiz²,

Martı́n-Martı́nez³

et al. 2007

CTMC

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This review mainly covers last five year literature on CCK1R agonists and antagonists. These CCK1R ligands have been found following the two usual and complementary strategies for drug discovery: rational design based on structure activity relationships on the CCK-7 and CCK-4 peptide sequences of the endogenous ligands and random screening of diverse compounds, followed by hit optimization. The first group includes: chimeric bifunctional opioid/CCK peptides, designed as opioid agonists with balanced CCK1R/CCK2R antagonist activity for the treatment of neuropathic pain, antagonist and agonist dipeptoids, and 1,3-dioxoperhydropyrido[1,2-c]pyrimidine- and anthranilic acid-based antagonists. Among the ligands derived from random screening, a few new 1,4-benzodiazepine-, 1,5-benzodiazepine-, and five member ring heterocycle-based CCK1R ligands have been reported. Finally, taking into account the importance of receptor mapping studies for ligand optimization and future precise de novo receptor structure-based design of new selective and more effective ligands, the most significant conclusions of these studies have also been reviewed.

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Centrally administered PD 140.548 N-methyl-d-glucamine prevents the autonomic responses to duodenal pain in sheep

Cited by 8 publications

References 29 publications

Evaluation of Animal-Based Indicators to Be Used in a Welfare Assessment Protocol for Sheep

Evaluation of Animal-Based Indicators to Be Used in a Welfare Assessment Protocol for Sheep

Central Glutaminergic Influences on Viscero-visceral Inhibitory Reflex During Colonal Descending Distension in Ovine Model

Strategies for Design of Non Peptide CCK1R Agonist/Antagonist Ligands

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