Centrally-induced coughs in the cat

Kasé, Yoshitoshi; Wakita, Yoshiakira; Kito, Go; Miyata, Takeshi; Yuizono, Tomokazu; Kataoka, Mikiko

doi:10.1016/0024-3205(70)90009-3

Cited by 31 publications

(10 citation statements)

References 6 publications

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“…However, in general, when aerosols are administered in man to test coughing, there is little information as to whether they act at the larynx, the trachea or the larger bronchi. Inflammation and other pathologies of the larynx, trachea and larger bronchi are powerful stimuli for coughing [5,8]. However, diseases at the alveolar level, such as pulmonary congestion and oedema, fibrosis and sarcoidosis, are not especially characterized by cough [8]; this is consistent with the experimental evidence that there are few or no receptors for coughing at distal sites.…”

Section: Stimuli To Coughsupporting

confidence: 61%

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Neurophysiology of the cough reflex

Jg¹

1995

Eur Respir J

343

197

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Section: Stimuli To Coughsupporting

confidence: 61%

“…Cough, unlike sneeze and hiccup, is not stereotyped in pattern but can show a wide variety of forms [8,9]. These can, in general, be mimicked by voluntary action.…”

Section: Control Nervous Mechanismsmentioning

confidence: 99%

Neurophysiology of the cough reflex

Jg¹

1995

Eur Respir J

343

197

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“…The cough reflex is triggered by the activation of rapidly adapting receptors (or 'irritant' receptors) within the larynx, trachea and the proximal bronchi, and of C-fibre endings found in the airway walls of bronchi (Karlsson et al, 1988b). Afferent signals are transmitted through the sensory vagal fibres to the cough centre, which has been experimentally identified as being in the region of the solitary nucleus in the medulla within the brain (Kase et al, 1970). From the cough centre the impulses travel through the efferent pathways to the respiratory muscles (diaphragm, intercostal and abdominal muscles) and the airways (Irwin et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Moguisteine: a novel peripheral non‐narcotic antitussive drug

Gallico¹,

Borghi²,

Rosa³

et al. 1994

British J Pharmacology

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“…Later experiments using electrical microstimulation, electrocoagulation, and local administration of antitussive drugs into medullary regions identified a cough center in the medial part of the dorsal medulla (Kasé et al, 1970;Kasé, 1980), an area overlapping the nucleus of the tractus solitarius (nTS) and adjacent structures. However, the precise location of second-and higher-order neurons generating cough remains unknown.…”

mentioning

confidence: 99%

Differential Brainstem Fos-Like Immunoreactivity after Laryngeal-Induced Coughing and Its Reduction by Codeine

1997

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We used the expression of the immediate-early gene c-fos, a marker of neuronal activation, to localize brainstem neuronal populations functionally related to fictive cough (FC). In decerebrate, paralyzed, and ventilated cats, the level of Fos-like immunoreactivity (FLI) was examined in five groups of animals: (1) controls, sham-operated unstimulated animals; (2) coughing cats, including both animals in which FC was elicited by unilateral electrical stimulation of the superior laryngeal nerve (SLN) and (3) those in which FC was elicited by bilateral SLN stimulation; (4) stimulated-treated cats, in which bilateral SLN stimulation was applied after selective blockade of FC by codeine; and (5) codeine controls, sham-operated unstimulated cats subjected to administration of codeine. Fifteen brainstem structures were compared for numbers of labeled cells. Because codeine selectively blocks FC, brainstem nuclei activated specifically during FC were identified as regions showing increased FLI after FC and significant reductions in FLI after FC suppression by codeine in stimulated-treated cats. In coughing animals, we observed a selective immunoreactivity in the interstitial and ventrolateral subdivisions of the nucleus of the tractus solitarius, the medial part of the lateral tegmental field, the internal division of the lateral reticular nucleus, the nucleus retroambiguus, the para-ambigual region, the retrofacial nucleus, and the medial parabrachial nucleus. FLI in all these nuclei was significantly reduced in stimulated-treated cats. Our results are consistent with the involvement of neurons overlapping the main brainstem respiratory-related regions as well as the lateral tegmental field and the lateral reticular nucleus in the neural processing of laryngeal-induced FC.

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Centrally-induced coughs in the cat

Cited by 31 publications

References 6 publications

Neurophysiology of the cough reflex

Neurophysiology of the cough reflex

Moguisteine: a novel peripheral non‐narcotic antitussive drug

Differential Brainstem Fos-Like Immunoreactivity after Laryngeal-Induced Coughing and Its Reduction by Codeine

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