Centrally mediated effects of neurohypophyseal hormones

Meisenberg, Gerhard; Simmons, William H.

doi:10.1016/0149-7634(83)90019-2

Cited by 74 publications

(12 citation statements)

References 183 publications

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“…Although the focus of much of thts work has been on the central nervous system distribution and neuroendocnne and autonomic homeostatic functions, effects of such peptides on learning and memory (reviewed m [153]) and maternal behawor (e.g., [178]) have also been demonstrated. In the followmg section, we will briefly review the effects of endogenous opiates, ACTH, MSH, oxytocin, and prolactm on male sexual behavior, with special reference to their possible d~rect action on the central nervous system (see Table 6).…”

Section: Neuropeptides Effects On Sexual Behaviormentioning

confidence: 99%

Pharmacological analysis of male rat sexual behavior

Bitran

Hull

1987

Neuroscience & Biobehavioral Reviews

409

155

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Section: Neuropeptides Effects On Sexual Behaviormentioning

confidence: 99%

Pharmacological analysis of male rat sexual behavior

Bitran

Hull

1987

Neuroscience & Biobehavioral Reviews

409

155

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“…In animal studies, oxytocin-administered ICV has been shown to induce stereotypic behaviors such as stretching, repetitive grooming, startle, and squeaking in mice (Drago et al, 1986;Insel and Winslow, 1991;Meisenberg and Simmons, 1983a;Nelson and Alberts, 1997), grooming, particularly of the genital regions, in rats (Drago et al, 1986;van Wimersma Greidanus et al, 1990), and wing-flapping in chicks (Panksepp, 1992). Peripheral and central oxytocin administration also inhibits extinction and this promotes perseverative behaviors (de Wied et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Hollander

Novotny

Hanratty

et al. 2003

Neuropsychopharmacol

624

403

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Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.

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“…Hormonal actions of AVP include regulation of plasma volume and osmolality (1,4) and, in the liver, promotion of glycogenolysis (5). In the brain, AVP is involved in the regulation of body temperature (4), blood pressure (6), brain development (7,8), and circadian rhythmicity (1) as well as in modulation of memory (9). AVP was also shown to be released during sexual arousal (10).…”

mentioning

confidence: 97%

Vasopressin and Oxytocin Neurons of the Human Supraoptic and Paraventricular Nucleus; Size Changes in Relation to Age and Sex

Ishunina

Swaab

1999

The Journal of Clinical Endocrinology & Metabolism

108

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The hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei consist of arginine vasopressin (AVP)- and oxytocin (OT)-synthesizing neurons that send projections to the neurohypophysis, whereas the PVN also projects to other brain areas. A growing body of evidence in animals suggests the presence of sex differences in the vasopressinergic and oxytocinergic systems. The present study was aimed at determining whether the sizes of AVP and OT neurons in the human SON and PVN show sex differences, as earlier studies demonstrated that a change in neuronal size is a sensitive parameter for activity. The minimal and maximal diameters were determined to estimate the volumes of cell somata and cell nuclei in AVP and OT neurons stained with an antibody against human glycoprotein-(22-39), a part of the AVP precursor, and a monoclonal anti-OT antibody in 15 men and 17 women ranging in age from 29-94 yr. The AVP neurons appeared to be larger in young men than in young women (< or =50 yr old). In elderly women (>50 yr old) AVP cell size considerably exceeded that in young women. In elderly men AVP neurons were larger than in young men and elderly women, although these differences were not significant. In addition, AVP cell size correlated positively with age in women but not in men. No significant differences were found in the AVP cell nucleus volumes among all four groups studied. Sex differences in the size of the PVN vasopressin neurons were pronounced at the left side (P = 0.048) and absent at the right side (P = 0.368), indicating the presence of functional lateralization in this nucleus. No difference was found in any morphometric parameter of OT neurons in the PVN among the 4 groups studied. Thus, our data demonstrate sex differences in the size of the AVP neurons, and thus in their function, that are age and probably also side dependent and the absence of such changes in OT neurons in the PVN. These data provide a basis for the reported higher AVP plasma levels in men compared to women.

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Centrally mediated effects of neurohypophyseal hormones

Cited by 74 publications

References 183 publications

Pharmacological analysis of male rat sexual behavior

Pharmacological analysis of male rat sexual behavior

Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

Vasopressin and Oxytocin Neurons of the Human Supraoptic and Paraventricular Nucleus; Size Changes in Relation to Age and Sex

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