Centrifugal Expansion of Fundus Autofluorescence Patterns in Stargardt Disease Over Time

Fundus Autofluorescence and Photoreceptor Cell Rosettes in Mouse Models

“…These findings also may be relevant to our understanding of the paracentral rings of elevated AF in retinitis pigmentosa 64 and/or the bright AF flecks that characterize recessive Stargardt disease. 51,65 …”

Fundus Autofluorescence in theAbca4−/−Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology

“…9,10 Later, atrophy of the central retina develops, which spreads centrifugally over time. 11 Based on findings in Abca4 À/À mice, the lack of ABCA4 function results in marked accumulation of the bisretinoid Nretinylidene-N-retinylethanolamine (A2E) in the RPE. 12 A2E is a major component of RPE lipofuscin and appears to have a role in retinal disease pathophysiology.…”

Treatment of Stargardt disease with dobesilate

“…On 5 December 2011, the patient returned to the clinic with a further severe reduction in VA. BCVA test in both eyes was 0.01 this time and the area presenting flecks and fluorescent aggregates had widen considerably when compared with the previous images, reaching the mid-periphery of the retina (figure 1C,D,c,d), findings indicating the end stage of the disease 2 3…”

“…A characteristic feature of STGD is the presence of yellow-white flecks of lipofuscin. Initially located at the macula, these deposits expanded centrifugally over time2 as figure 1 illustrates. During fluorescence angiography lipofuscin absorbs blue excitatory light and emits a characteristic stippled hyperfluorescence 13…”