Centripetal and centrifugal reorganizations of frequency map of auditory cortex in gerbils

Sakai, Masashi; Suga, Nobuo

doi:10.1073/pnas.102165399

Cited by 45 publications

(23 citation statements)

References 52 publications

(63 reference statements)

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“…Therefore the hypothesis proposed by Suga et al (2000) predicts that focal electric stimulation of the sensory cortex evokes "center-surround" reorganization of sensory maps: centripetal shifts of tuning curves (or receptive fields) at the center and centrifugal shifts at the surround. Thus far, however, center-surround reorganization has been found only in the Mongolian gerbil (Sakai and Suga 2002). This is probably because the centrifugal shifts are small and short lasting, making the surround difficult to find.…”

Section: Introductionmentioning

confidence: 86%

“…The area for centripetal BF shifts was about 800 m in diameter, whereas the surrounding zone for centrifugal BF shifts was about 250 m wide. Focal electric stimulation of the AC thus evoked center-surround reorganization in the big brown bat, as in the Mongolian gerbil (Sakai and Suga 2002). The centersurround reorganization is presumably related to excitatory and inhibitory connections in the auditory cortex (see DISCUSSION).…”

Section: Off-line Data Processingmentioning

confidence: 99%

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Lateral Inhibition for Center-Surround Reorganization of the Frequency Map of Bat Auditory Cortex

Suga

2004

Journal of Neurophysiology

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Ma, Xiaofeng and Nobuo Suga. Lateral inhibition for center-surround reorganization of the frequency map of bat auditory cortex. J Neurophysiol 92: 3192-3199, 2004; doi:10.1152/jn.00301.2004. Repetitive acoustic stimulation, auditory fear conditioning, and focal electric stimulation of the auditory cortex (AC) each evoke the reorganization of the central auditory system. Our current study of the big brown bat indicates that focal electric stimulation of the AC evokes center-surround reorganization of the frequency map of the AC. In the center, the neuron's best frequencies (BFs), together with their frequency-tuning curves, shift toward the BFs of electrically stimulated cortical neurons (centripetal BF shifts). In the surround, BFs shift away from the stimulated cortical BF (centrifugal BF shifts). Centripetal BF shifts are much larger than centrifugal BF shifts. An antagonist (bicuculline methiodide) of inhibitory synaptic transmitter receptors changes centrifugal BF shifts into centripetal BF shifts, whereas its agonist (muscimol) changes centripetal BF shifts into centrifugal BF shifts. This reorganization of the AC thus depends on a balance between facilitation and inhibition evoked by focal cortical electric stimulation. Unlike neurons in the AC of the big brown bat, neurons in the Doppler-shifted constant-frequency (DSCF) area of the AC of the mustached bat are highly specialized for fine-frequency analysis and show almost exclusively centrifugal BF shifts for focal electric stimulation of the DSCF area. Our current data indicate that in the highly specialized area, lateral inhibition is strong compared with the less-specialized area and that the specialized and nonspecialized areas both share the same inhibitory mechanism for centrifugal BF shifts.

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Section: Introductionmentioning

confidence: 86%

Section: Off-line Data Processingmentioning

confidence: 99%

Lateral Inhibition for Center-Surround Reorganization of the Frequency Map of Bat Auditory Cortex

Suga

2004

Journal of Neurophysiology

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“…(6) As in the Mongolian gerbil (Sakai and Suga, 2002), focal electric stimulation of AI evokes the center-surround reorganization of the tonotopic-map of AI (Ma and Suga, 2004).…”

Section: Discussionmentioning

confidence: 99%

Specific and Nonspecific Plasticity of the Primary Auditory Cortex Elicited by Thalamic Auditory Neurons

Ma¹,

Suga²

2009

J. Neurosci.

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The ventral and medial divisions of the medial geniculate body (MGBv and MGBm) respectively are the lemniscal and nonlemniscal thalamic auditory nuclei. Lemniscal neurons are narrowly frequency tuned and provide highly specific frequency information to the primary auditory cortex (AI), whereas nonlemniscal neurons are broadly frequency tuned and project widely to auditory cortical areas including AI. The MGBv and MGBm are presumably different not only in auditory signal processing, but also in eliciting cortical plastic changes. We electrically stimulated MGBv or MGBm neurons and found the following: (1)

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“…Tonotopically organized cortical auditory areas are commonly interconnected (1). The cortico-cortical interaction within the primary auditory cortex has been studied (2)(3)(4)(5)(6). However, the cortico-cortical interaction between different cortical auditory areas has not yet been studied.…”

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confidence: 99%

Modulation of auditory processing by cortico-cortical feed-forward and feedback projections

Tang

Suga

2008

Proc. Natl. Acad. Sci. U.S.A.

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The auditory center in the cerebrum, the auditory cortex, consists of multiple interconnected areas. The functional role of these interconnections is poorly understood. The auditory cortex of the mustached bat consists of at least nine areas, including the frequency modulation-frequency modulation (FF) and dorsal fringe (DF) areas. The FF and DF areas consist of neurons tuned to specific echo delays carrying target-distance information. The DF area is hierarchically at a higher level than the FF area. Here, we show that the feedback projection from the DF area to the FF area shifts the delay-tuning of FF neurons toward that of the stimulated DF neurons. In contrast, the feed-forward projection from the FF area to the DF area shifts the delay-tuning of DF neurons away from that of the stimulated FF neurons. The lateral projection within the DF area shifts the delay-tuning of DF neurons toward that of the stimulated DF neurons. In contrast, the lateral projection within the FF area shifts the delay-tuning of FF neurons away from that of the stimulated FF neurons. The delay-tuning shift evoked by the DF stimulation was 2.5 times larger than that evoked by the FF stimulation. Our data indicate that the FF-DF feed-forward and FF-FF lateral projections shape the highly selective neural representation of the tuning of the excited DF neurons, whereas the DF-FF feedback and DF-DF lateral projections enhance the representation of the selected tuning, perhaps, for focal processing of information carried by the excited FF neurons.bat ͉ cortical electric stimulation ͉ delay tuning ͉ hearing ͉ plasticity T he auditory center in the cerebrum, the auditory cortex, consists of multiple, anatomically distinct areas, as do other sensory cortices. Its functional organization beyond tonotopy, however, has hardly been explored, except for the auditory cortex of the mustached bat, Pteronotus parnellii. Tonotopically organized cortical auditory areas are commonly interconnected (1). The cortico-cortical interaction within the primary auditory cortex has been studied (2-6). However, the cortico-cortical interaction between different cortical auditory areas has not yet been studied. The interaction between different cortical areas in a sensory system has thus far been studied only in the cat visual cortex by Galuske et al. (7). They found that inactivation of the visuoparietal cortex decreases the orientation and direction sensitivities of neurons in area 18. That is, they studied the effect of the feedback projection (the projection from a higher to a lower area in a signal processing hierarchy), but not that of the feed-forward projection (the projection from a lower to a higher area).A microchiropteran bat emits orientation sounds (biosonar pulses or, simply, pulses) and listens to their echoes for echolocation. The delay of an echo from the emitted pulse carries target-distance information. In the mustached bat, the biosonar pulse consists of a long constant frequency (CF) and a short frequency-modulated (FM) component, and these com...

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Centripetal and centrifugal reorganizations of frequency map of auditory cortex in gerbils

Cited by 45 publications

References 52 publications

Lateral Inhibition for Center-Surround Reorganization of the Frequency Map of Bat Auditory Cortex

Lateral Inhibition for Center-Surround Reorganization of the Frequency Map of Bat Auditory Cortex

Specific and Nonspecific Plasticity of the Primary Auditory Cortex Elicited by Thalamic Auditory Neurons

Modulation of auditory processing by cortico-cortical feed-forward and feedback projections

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