2008
DOI: 10.1016/j.cell.2008.05.039
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Centrosome Amplification Can Initiate Tumorigenesis in Flies

Abstract: Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic instability and so tumorigenesis. To test this hypothesis, we generated Drosophila lines that have extra centrosomes in approximately 60% of their somatic cells. Many cells with extra centrosomes initially form multipolar spindles, but these spindles ultimately become bipolar. This requires a delay in mitosis that is mediated by the spindle assembly checkpoint (… Show more

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Cited by 516 publications
(662 citation statements)
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“…This thesis shows evidence correlating with previous investigations in other systems, in which centrosomes were inactivated as the end-result of DNA damage induced pathways in mitosis (Sibon et al, 2000;Sibon, 2003;Takada et al, 2003;Löffer et al, 2006). Furthermore, it is possible that the control of CEP63 centrosome function by ATM and ATR could potentially participate in preventing genomic instability and cellular transformations, in which centrosomes role has been proven (Basto et al, 2008).…”
Section: Atm and Atr Inhibition Of Xcep63 Regulatory Role In Spindlementioning
confidence: 99%
“…This thesis shows evidence correlating with previous investigations in other systems, in which centrosomes were inactivated as the end-result of DNA damage induced pathways in mitosis (Sibon et al, 2000;Sibon, 2003;Takada et al, 2003;Löffer et al, 2006). Furthermore, it is possible that the control of CEP63 centrosome function by ATM and ATR could potentially participate in preventing genomic instability and cellular transformations, in which centrosomes role has been proven (Basto et al, 2008).…”
Section: Atm and Atr Inhibition Of Xcep63 Regulatory Role In Spindlementioning
confidence: 99%
“…En réalité, il semble que la plupart des cellules cancé-reuses soient capables de regrouper les centrosomes surnuméraires pour former un fuseau bipolaire. Ce phénomène, encore mal compris, est appelé le « regroupement de centrosomes » (ou centrosome clustering) et son existence à été démontrée in vitro comme in vivo [12][13][14][15]. Ce mécanisme, qui se met en place peu de temps avant la ségrégation des chromatides soeurs, peut avoir de graves conséquences pour la cellule en générant de l'aneuploïdie.…”
Section: Contrôle Du Nombre De Centrosomesunclassified
“…Néanmoins, il semble que la dynéine et la kinésine NCD (non claret disjunctional protein), qui sont des moteurs associés aux microtubules du fuseau mitotique, soient impliquées dans ce processus de regroupement des centrosomes. De même, la protéine NuMA (nuclear mitotic apparatus protein 1) associée aux pôles du fuseau mitotique serait également impliquée [12,14,[18][19][20][21]. Ces protéines contraignent les microtubules à former un fuseau bipolaire, ce qui est la fonction première de ces molécules dans des cellules normales (comme elles le font pour les fuseaux méiotiques qui sont assemblés en absence de centrosomes).…”
Section: Contrôle Du Nombre De Centrosomesunclassified
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