CeO<sub>2</sub> nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment

Naz, Sania; Kazmi, Syeda Tayyaba Batool; Zia, Muhammad

doi:10.1002/jbt.22291

Cited by 24 publications

(20 citation statements)

References 35 publications

(44 reference statements)

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“…Undoubtedly, the use of nanoceria as a biomaterial will continue to be one of the highlights of biology, biomedical, and materials science in the coming years. However, this nanoparticle has been considered in the category of hazardous compounds by Organization for Economic Co-operation and Development (OECD), and OECD recommends that the toxicity profile should be investigated with further experimental studies (Naz et al, 2019). In particular, the methods of studies for determining toxicity may be varied, as well as the parameters related to the particle (size, shape, surface load, crystal structure, concentration, and application time, etc.)…”

Section: Introductionmentioning

confidence: 99%

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

Arslan

Akbaba

2020

Toxicol Ind Health

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Cerium (IV) oxide (CeO2), which is used as a biomaterial, has wide application in areas such as the biomedical, glass polishing, electronic, automotive, and pharmacology industries. Comparing with the literature, in this study, the genotoxic effects of cerium (IV) oxide microparticles (COMPs) and cerium (IV) oxide nanoparticles (CONPs) were investigated for the first time in human peripheral blood cultures at concentrations of 0.78, 1.56, 3.125, 6.25, 12.5, 25, and 50 ppm for 72 h under in vitro conditions. Particle sizes of COMPs and CONPs were determined using scanning electron microscopic analysis. Micronucleus and chromosome aberration tests were used to determine the genotoxicity of COMPs and CONPs. The average particle sizes of COMPs and CONPs were approximately 148.25 and 25.30 nm, respectively. It was determined that CeO2 particles in both micro and nano sizes were toxic at all concentrations compared to the negative control group (distilled water). Importantly, COMPs and CONPs were genotoxic even at the lowest concentration (0.78 ppm). Comparing particle sizes, the data indicated that COMPs were more toxic than CONPs. The results suggest that genotoxicity of COMPs and CONPs may be a function of applied concentrations and particle sizes.

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Section: Introductionmentioning

confidence: 99%

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

Arslan

Akbaba

2020

Toxicol Ind Health

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“…Therefore, any substance with ability to PKI activity have significant importance in cancer research. The present results revealed the presence of potent phytochemicals in different extracts such as aqueous, methanol and ethanol which is reported to be involved in protein kinases inhibition (Naz, Kazmi, & Zia, 2019;Tabassum et al, 2019).…”

Section: Protein Kinase Inhibition (Pki) Assaymentioning

confidence: 53%

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Lactuca orientalis (Boiss.) Boiss. is one of the most frequently used ethnomedicinal plant. This research study was designed to decipher the phytochemical screening, pharmacological potential and implementation of scanning electron microscope (SEM). Six different solvents were used to prepare L. orientalis (LO) seed extracts.Phytochemical and antioxidant activities were determined calorimetrically. To investigate antidiabetic, α-amylase inhibition assay was performed. Brine shrimp assay was performed for cytotoxicity and anti-leishmanial via MTT assay. Disc-diffusion assay was performed to detect protein kinase inhibitory, antibacterial and antifungal activities. SEM was used as identification tool. Significant amount of phenolic and flavonoid content were identified in methanol extract (LOSM) (95.76 ± 3.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for LOSM. Significant total antioxidant capacity (90.60 ± 1.55 AAE/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was found in LOSM (78.20 ± 1.58%). The highest LD 50 of brine shrimp was found for n-Hexane extract (LOSH) 13.03 μg/ml. All extracts showed strong antileishmanial activity except LOSH. L. orientalis seeds showed significant protein kinase inhibition, antibacterial and antifungal activities. The seeds of L. orientalis were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. The outer-periclinal wall convex with fine texture. In conclusion, our findings scientifically support ethnomedicinal and biological potentials of L. orientalis seeds. In future, L. orientalis seeds need to be explored for identification and isolation of bioactive compounds. The results obtained necessitate further in vivo studies to evaluate their pharmacological potentials. Key points• An extensive phytochemical potential study on the seeds of novel medicinal plant Lactuca orientalis (Boiss.) Boiss. was reported.• Scanning electron microscopy was used as an identification tool and reported for the first time for seeds of L. orientalis.

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“…Therefore, any substance with ability to protein kinase inhibition (PKI) activity have significant importance in cancer research. The present results revealed the presence of potent phytochemicals in different extracts such as aqueous, methanol, and ethanol which is reported to be involved in protein kinases inhibition (Naz, Kazmi, & Zia, 2019;Tabassum et al, 2019).…”

Section: Protein Kinase Inhibition Assaymentioning

confidence: 54%

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Sophora alopecuroides L. is a highly medicinal plant. The aim of the current study was to determine the phytochemical screening, pharmacological potentials and application of scanning electron microscope (SEM) of S. alopecuroides (SA) seeds. To achieve this purpose, six different solvents were used to prepare SA seed extracts. Phytochemical and antioxidant activities were determined calorimetrically. To investigate the antidiabetic activity, α-amylase inhibition assay was determined. Brine shrimp assay was used to determine cytotoxicity potential. Anti-leishmanial potential was confirmed using MTT assay. Disc-diffusion method was used to detect protein kinase inhibitory, antibacterial and antifungal activities and showed significant results. SEM analysis was used as an identification tool. Considerable amount of phenolic and flavonoid contents were identified in methanol extract (SASM) (93.76 ± 2.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for SASM. Significant total antioxidant capacity (90.60 ± 1.55 alpha amylase enzyme [AAE]/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was reported in SASM (78.20 ± 1.58%). Highest LD 50 of brine shrimp was found for n-hexane extract (SASH) 13.03 μg/ml. All extracts showed strong anti-leishmanial activity except SASH. The seeds of SA were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. In conclusion, our experimental findings highly support the ethnomedicinal and biological potentials of the SA seeds. Moreover, SA seeds need to be explored for identification and isolation of bioactive compounds. In future, we recommend further in vivo toxicity assays and clinical efficacies to further evaluate its different biomedical properties.

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CeO₂ nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment

Cited by 24 publications

References 35 publications

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

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CeO2 nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment

Cited by 24 publications

References 35 publications

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

In vitro genotoxicity assessment and comparison of cerium (IV) oxide micro- and nanoparticles

Antimicrobial, cytotoxic, antioxidants, enzyme inhibition activities, and scanning electron microscopy of Lactuca orientalis (Boiss.) Boiss. seeds

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

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CeO₂ nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment