2024
DOI: 10.1038/s41467-024-52705-8
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CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice

Xueguang Zhang,
Gelin Huang,
Ting Jiang
et al.

Abstract: Spermiogenesis, the complex transformation of haploid spermatids into mature spermatozoa, relies on precise spatiotemporal regulation of gene expression at the post-transcriptional level. The mechanisms underlying this critical process remain incompletely understood. Here, we identify centrosomal protein 112 (CEP112) as an essential regulator of mRNA translation during this critical developmental process. Mutations in CEP112 are discovered in oligoasthenoteratospermic patients, and … Show more

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