‘Cephalandole A’ analogues as a new class of antioxidant agents: Design, microwave-assisted synthesis, bioevaluation, SAR and in silico studies

Mild Iron-Catalyzed Oxidative Cross-Coupling of Quinoxalinones with Indoles

“…1 H NMR and 13 C NMR spectra were recorded on a Bruker AVANCE NEO 400 MHZ (Karlsruhe, Germany). Spectra were calibrated relative to resonances of the deuterated solvents for proton and carbon chemical shifts: DMSO (δ = 2.50 for 1 H NMR and δ = 39.50 for 13 C NMR), CDCl 3 (δ = 7.26 for 1 H NMR and δ = 77.16 for 13 C NMR).…”

“…1 H NMR and 13 C NMR spectra were recorded on a Bruker AVANCE NEO 400 MHZ (Karlsruhe, Germany). Spectra were calibrated relative to resonances of the deuterated solvents for proton and carbon chemical shifts: DMSO (δ = 2.50 for 1 H NMR and δ = 39.50 for 13 C NMR), CDCl 3 (δ = 7.26 for 1 H NMR and δ = 77.16 for 13 C NMR). Data are reported as follows: chemical shift δ/ppm, integration (1H only), multiplicity (s = singlet, d = doublet, t =triplet, dd = doublet of doublets, m = multiplet; 13 C signals are singlets unless otherwise stated), coupling constants J in Hz.…”

“…The residue was purified by column chromatography on silica gel to produce the desired product 1. See Supporting Information for more details including the chemical structural formulae and 1 H NMR and 13 C NMR spectra of the products.…”

“…The chemical structural formulae and 1 H NMR and 13 C NMR spectra of products 3a-3t can be seen in Supporting Information.…”

“…1 H NMR (400 MHz, DMSO-d 6 ) δ 11.79 (s, 1H), 9.03-8.85 (m, 2H), 7.92 (d, J = 7.9 Hz, 1H), 7.61-7.48 (m, 3H), 7.46-7.33 (m, 1H), 7.33-7.18 (m, 2H), 3.74 (s, 3H). 13 C NMR (101 MHz, DMSO-d 6 ) δ 153.66, 150.62, 136.29, 133. 18, 132.96, 131.49, 128.36, 128.25, 126.31, 123.42, 123.02, 122.53, 120.98, 114.42, 111.88, 111.41, 29.09.…”