Cephalopod Species Captured by Deep-water Exploratory Trawling in the Northeastern Ionian Sea

Lefkaditou, Eugenia; Mytilineou, Chryssi; Maiorano, P.; D’Onghia, Gianfranco

doi:10.2960/j.v31.a33

Cited by 22 publications

(24 citation statements)

References 17 publications

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“…Concerning Xenopus laevis and Loligo forbesi, two aquatic species, the Xenopus is submerged for long periods of time, thus making standard inhalation techniques impractical (63), and Loligo forbesi lives in deep water (250-500 m) (64). According to a phylogenetic tree conducted on the p53 DNA-binding domain of Spalax and 35 other species (Fig.…”

Section: Spalax P53 Favors Growth Arrest But Not Apoptotic Target Gementioning

confidence: 99%

Evolution of p53 in hypoxia-stressedSpalaxmimics human tumor mutation

Ashur‐Fabian

Avivi

Trakhtenbrot

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

108

134

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The tumor suppressor gene p53 controls cellular response to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and͞or apoptosis. Inactivation of p53, found in 40 -50% of human cancers, confers selective advantage under hypoxic microenvironment during tumor progression. The mole rat, Spalax, spends its entire life cycle underground at decidedly lower oxygen tensions than any other mammal studied. Because a wide range of respiratory adaptations to hypoxic stress evolved in Spalax, we speculated that it might also have developed hypoxia adaptation mechanisms analogous to the genetic͞epige-netic alterations acquired during tumor progression. Comparing Spalax with human and mouse p53 revealed an arginine (R) to lysine (K) substitution in Spalax (Arg-174 in human) in the DNAbinding domain, identical to known tumor associated mutations. Multiple p53 sequence alignments with 41 additional species confirmed that Arg-174 is highly conserved. Reporter assays uncovered that Spalax p53 protein is unable to induce apoptosisregulating target genes, resulting in no expression of apaf1 and partial expression of puma, pten, and noxa. However, cell cycle arrest and p53 stabilization͞homeostasis genes were overactivated by Spalax p53. Lys-174 was found critical for apaf1 expression inactivation. A DNA-free p53 structure model predicts that Arg-174 is important for dimerization, whereas Spalax Lys-174 prevents such interactions. Similar neighboring mutations found in human tumors favor growth arrest rather than apoptosis. We hypothesize that, in an analogy with human tumor progression, Spalax underwent remarkable adaptive p53 evolution during 40 million years of underground hypoxic life.

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Section: Spalax P53 Favors Growth Arrest But Not Apoptotic Target Gementioning

confidence: 99%

Evolution of p53 in hypoxia-stressedSpalaxmimics human tumor mutation

Ashur‐Fabian

Avivi

Trakhtenbrot

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

108

134

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“…It has been reported at depths ranging from 17 to 900 m, with its deepest records reported from the northeastern Ionian Sea (LEFKADITOU et al, 2003a). In the Aegean Sea it has been caught down to 770 m, with the greatest part of its population distributed over the continental slope (LEFKADITOU et al, 2003b, LEFKADI-TOU & KASPIRIS, 2004.…”

Section: Rondeletiola Minor (Naef 1912)mentioning

confidence: 99%

“…In Hellenic seas it has been reported in the Aegean (N< 40AE 30') and the Ionian Seas, being caught at depths between 120 and 800 m, more frequently during summer and autumn, but never exceeding 10 individuals per hour of trawling (LEFKADITOU et al, 2003a).…”

Section: Todarodes Sagittatus (Lamarck 1798)mentioning

confidence: 99%

“…In the temperate part of its distributional range it is mainly found over the shelf, but in subtropical areas and in the Mediterranean in deeper waters, reaching depths of 720 m in the Ionian Sea (LEFKADITOU et al, 2003a). It is widespread in Hellenic seas, being more common in the neritic zone of regions with abrupt waters like the Ionian Sea and the area of the Kyklades, Kriti and the Dodekanisos islands, while it is scarce north of 40AE ¡ in the Aegean Sea (KOUTSOUBAS et al, 1999;LEFKA-DITOU, 2006).…”

Section: Loligo Forbesi (Steenstrup 1856)mentioning

confidence: 99%

“…It is associated with sandy and muddy bottoms and it mostly occurs on the shelf break and upper slope, not ascending to the surface or approaching the shore. Its populations have been considered as indicative of the cephalopod community at these depths, in the south-eastern Atlantic (ROELEVELD et al, 1992), the Balearic Sea (QUETGLAS et al, 2000), the north Tyrrhenian (SANCHEZ et al, 1998), the south-eastern Adriatic (KRSTULOVIC-SIFNER et al, 2005) and the eastern Ionian Sea (LEFKADITOU et al, 2001). Mature individuals are found all year round, with maximum incidence of mature females from mid-spring to early autumn (GONZALEZ et al, 1994;RELINI et al, 1999;ROBIN et al, 2002).…”

Section: Todaropsis Eblanae (Ball 1841)mentioning

confidence: 99%

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Molluscan species of minor commercial interest in Hellenic seas: Distribution, exploitation and conservation status

et al. 2008

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Recognising the need for data gathering at taxon level besides the taxa of commercial interest and those listed as endangered in the Protocol of the Barcelona Convention, but still exploited by Man, the present study attempts to gather and review the available scientific information on molluscs of minor commercial importance in order to assist in the adequate management and protection of their populations. Forty one species (18 gastropods, 13 bivalves, and 10 cephalopods) of minor commercial interest are treated in the present work with details on their biogeographic distribution, exploitation and conservation status in Hellas. Apart from a few species (e.g., Pinna nobilis, Lithophaga lithophaga, Donacilla cornea), and these only at a local scale, there is no population assessment in Hellenic seas. The existing legislation for eleven of these species is not enforced in practice, and seems insufficient to guarantee their conservation. It is suggested that targeted collection data, networked nationally and internationally, should be promoted so this invaluable source of biodiversity information can be accessed for conservation and planning purposes.

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