Cephaloridine in Gonorrhoea and Syphilis

Bacterial resistance to penicillins and cephalosporins

“…gonorrhoeae, appear to have gradually built up intrinsic resistance over the years, and now seem about to become clinically resistant. Hejzlar & Vymola (1965) and Amies (1967) have indicated the alarming rise in the in vitro resistance of gonococci to benzylpenicillin recently, an increase paralleled by a rise in the failure rate for the single-dose treatment of gonorrhoea (Kjellander & Finland, 1963;Oller, 1967). As gonococci have not yet been shown to produce penicillinase, this increased resistance is another example of an in vivo selection of Class I11 mutants from a predominantly Class I population.…”

Sensitivity of Neisseria gonorrhoeae to penicillin and other antibiotics. Studies carried out in Toronto during the period 1961 to 1968.

“…Cephaloridine Oller (1967aOller ( , 1967b has reported his findings in two clinical studies supported by antibiotic disc sensitivity tests. Strains of gonococci that showed a reduced sensitivity to penicillin also showed some degree of resistance to cephaloridine; and, in general, the response to treatment was correlated with the degree of sensitivity to the drug in vitro.…”

Single-session treatment of uncomplicated gonorrhoea in men, using penicillin combined with cotrimoxazole. Controlled trial comparing four different treatment schedules with observations on antibiotic sensitivities of gonococci and a review of the literature.

“…procaine penicillin. Gjessing and Odegaard (1965, 1967)-97 per cent. success with 600,000 u. procaine penicillin and 1 g. ampicillin given in 500 male cases and 96 per cent.…”