Cephalosporin‐resistant <i>Escherichia coli</i> isolated from farm workers and pigs in northern Vietnam

Dang, Son Thi Thanh; Bortolaia, Valeria; Nhat, Tran Thi; Le, Hien Thi Thu; Dalsgaard, Anders

doi:10.1111/tmi.13054

Cited by 17 publications

(19 citation statements)

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“…Escherichia coli (E. coli) recovered from swine workers and pigs in northern Vietnam, a region characterized by rapid growth in industrial swine production and heavy agricultural antibiotic usage [43]. ESBLs are of particular concern because these genes are encoded by plasmids that are easily transferred across bacterial species, potentially resulting in widespread antibiotic resistance.…”

Section: Dang Et Al Reported On a Study Of Cefotaxime (Ctx)-resistanmentioning

confidence: 99%

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Dignard

Leibler

2019

Curr Envir Health Rpt

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Section: Dang Et Al Reported On a Study Of Cefotaxime (Ctx)-resistanmentioning

confidence: 99%

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Dignard

Leibler

2019

Curr Envir Health Rpt

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“…Antimicrobial resistance (AMR) threatens to destabilise progression in human health and animal health by reducing the ability to treat diseases and causing complications to medical procedures. Activities impacting on the environment and actions in the human health care sector and the animal health sector are all considered to be contributing to the development of pathogen resistance to antimicrobials [1][2][3][4][5]. Contamination of the environment with pharmaceutical waste, for example, is one of the means by which resistant genes can transfer among pathogens in the environment [4,6].…”

Section: Introductionmentioning

confidence: 99%

“…Vietnam is a potential hot spot for the emergence of AMR due to the high burden of infectious diseases that are directly transmissible and that are foodborne, coupled with limited enforcement of regulations to penalise noncompliance, and the relatively unregulated access to antimicrobials for humans and high antimicrobial usage for livestock [1,8,19,20]. Vietnam was one of the first countries to develop a National Action Plan to combat AMR in the World Health Organization (WHO) Western Pacific Region [21].…”

Section: Introductionmentioning

confidence: 99%

“…For the purposes of this study, we specifically focused on antibiotic resistance which is a key component of AMR. The objectives of this project were to [1]: Identify potential advantages of cross-sectoral collaborations between key informants from the animal health and human health sectors to address AMR in Vietnam; and [2] Identify the potential challenges that key informants in the animal health and human health sectors face during investigation of antibiotic resistance within the pork value chain in Vietnam.…”

Section: Introductionmentioning

confidence: 99%

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The challenges of investigating antimicrobial resistance in Vietnam - what benefits does a One Health approach offer the animal and human health sectors?

et al. 2020

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Background: The One Health concept promotes the enhancement of human, animal and ecosystem health through multi-sectorial governance support and policies to combat health security threats. In Vietnam, antimicrobial resistance (AMR) in animal and human health settings poses a significant threat, but one that could be minimised by adopting a One Health approach to AMR surveillance. To advance understanding of the willingness and abilities of the human and animal health sectors to undertake investigations of AMR with a One Health approach, we explored the perceptions and experiences of those tasked with investigating AMR in Vietnam, and the benefits a multi-sectorial approach offers. Methods: This study used qualitative methodology to provide key informants' perspectives from the animal and human health sectors. Two scenarios of food-borne AMR bacteria found within the pork value chain were used as case studies to investigate challenges and opportunities for improving collaboration across different stakeholders and to understand benefits offered by a One Health approach surveillance system. Fifteen semi-structured interviews with 11 participants from the animal and six from the human health sectors at the central level in Hanoi and the provincial level in Thai Nguyen were conducted. Results: Eight themes emerged from the transcripts of the interviews. From the participants perspectives on the benefits of a One Health approach: (1) Communication and multi-sectorial collaboration; (2) Building comprehensive knowledge; (3) Improving likelihood of success. Five themes emerged from participants views of the challenges to investigate AMR: (4) Diagnostic capacity; (5) Availability and access to antibiotics (6) Tracing ability within the Vietnamese food chain; (7) Personal benefits and (8) Managing the system. Conclusion: The findings of this study suggest that there is potential to strengthen multi-sectorial collaboration between the animal and human health sectors by building upon existing informal networks. Based on these results, we recommend an inclusive approach to multi-sectorial communication supported by government network activities to facilitate partnerships and create cross-disciplinary awareness and participation. The themes relating to diagnostic capacity show that both sectors are facing challenges to undertake investigations in AMR. Our results indicate that the need to strengthen the animal health sector is more pronounced.

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“…Antibiotic stewardship has been appointed as the intervention with the highest potential to reduce ESBL in livestock. In countries with a high use of antimicrobials a high prevalence of ESBL in livestock and farm workers is seen 53,54 . There is a known association between the use of cephalosporins and the emergence of ESBL 55,56 .…”

Section: Reduction Of Human Exposure To Esbl In Livestockmentioning

confidence: 99%

Epidemiology of ESBL - About pigs and humans

Dohmen¹

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Chapter 1 bla CTX-M-1 is common in poultry, cattle and pigs, but in Asia mainly bla CTX-M-14 is reported in poultry and other types of the CTX-M family (bla CTX-M-2 , bla CTX-M-14 and bla CTX-M-15) are reported in cattle and pigs 4. Since around 2000, ESBL-producing Enterobacteriaceae have emerged globally, in both humans and animals 4. An increasing interest was raised for the transmission of ESBL from animal to human. This focus was enhanced by publication of data where a certain level of molecular relatedness was found between human clinical isolates and isolates obtained from poultry and chicken retail meat 27. A degree of similarity in ESBL genes, plasmids and E. coli genotypes found in humans and livestock is suggestive for transmission. Results on ESBL and other antimicrobial resistant bacteria suggest that transmission from animals to humans can occur through (in) direct contact with livestock or animal derived food products during work 28-30. Next to the potential occupational health risk for farmers and slaughterhouse workers, further efflux of ESBL from (humans exposed to) livestock or food products into the general population might occur. In the Netherlands, most information on ESBL in animals and the potential transmission to humans was obtained in the poultry field. An overview on the distribution of ESBL genes in pigs, pig farming community and slaughterhouse workers in the Netherlands was not available yet. Therefore, sufficient data to quantify the relevant importance of this route of transmission was not available. Identification of ESBL-producing Enterobacteriaceae, ESBL genes and plasmids in humans and their exposure to ESBL on farms and in a slaughterhouse should provide further insights regarding personal and public health risks. Objectives and outline Considering the adverse effects that ESBL-producing Enterobacteriaceae from animals can have on public health and the gap in data on ESBL in pig farming, the main objective of this thesis is to assess the importance and relevance of the pig production chain for ESBL carriage in humans. A strong emphasis will be drawn to the occupational risk of acquiring ESBL when working with pigs or pig products. This main objective can be explained in several sub objectives, namely:

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Cephalosporin‐resistant Escherichia coli isolated from farm workers and pigs in northern Vietnam

Abstract: The high occurrence of ESBL-producing E. coli in pig farmers and pigs could present a risk for spillover of these bacteria from pig farms into the community. Genomic studies are needed to elucidate reservoirs and transmission routes of ESBL-producing E. coli at livestock farms.

Cited by 17 publications

References 30 publications

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

The challenges of investigating antimicrobial resistance in Vietnam - what benefits does a One Health approach offer the animal and human health sectors?

Epidemiology of ESBL - About pigs and humans

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