Cephalotaxine-type alkaloids with antiproliferation effects from the branches and leaves of Cephalotaxus fortunei var. alpina

Li, Yan-zhi; Wang, Yuetong; Zhao, Chunxue; Jing, Qinxue; Jiang, Chunyu; Lin, Bin; Li, Dahong; Li, Bingqian; Jing, Yongkui; Yuan, Jing; Hua, Hui‐Ming

doi:10.1016/j.fitote.2021.105037

Cited by 7 publications

(3 citation statements)

References 27 publications

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“…The alkaloids of the Cephalotaxus genus include cephalotaxine-type and homoerythrina-type. 33 Seven undescribed Cephalotaxus alkaloids and twenty-five known analogues were isolated from the twigs and leaves of Cephalotaxus fortunei . 1 represents the first nitrogen-oxidized homoerythrina-type alkaloid.…”

Section: Discussionmentioning

confidence: 99%

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

et al. 2022

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“…alpina , an endemic coniferous species, mainly grows at an altitude of 1800—3700 m in the southwest of China. [ 1 ] Previous chemical studies on this species have led to the identification of a number of alkaloids, [ 2 ] flavonoids, [ 3 ] abietane diterpenoids, [ 3 ] and in particular cephalotane diterpenoids/norditerpenoids, [ 3‐5 ] an interesting class of polycyclic natural products. The history of research on this compound class can be traced back to as early as 1970s, when harringtonolide (or hainanolide), a C 19 cephalotane troponoid showing remarkable anti‐tumor activity, was first discovered.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Cephalotane‐Type Norditerpenoids from Cephalotaxus fortunei var. alpina

Zhou

Zimbres

et al. 2022

Chin. J. Chem.

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A chemical investigation of the 95% EtOH extract of the seeds of Cephalotaxus fortunei var. alpina led to the isolation of nine new cephalotane-type norditerpenoids, ceforalides A-I (1-9), and two known analogues (10 and 11). Compounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids, of which compound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone A-ring. Compound 9 is a rare 13,14-seco-17-nor-cephalotane-type diterpenoid. Their structures were determined based on NMR, HRESIMS, ECD, and X-ray diffraction analysis. Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity.

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“…The reason for selecting Cephalotaxus harringtonia fruit is its tremendous medical applications, including anticancer, internal bleeding, cough, hookworm disease treatment, anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, and so on ( Da-Cheng et al, 2021 ). Additionally, various components like flavonoids, phenolics, lignans, sesquiterpenoids, and diterpenoids are present in Cephalotaxus species ( Da-Cheng et al, 2021 ; Li et al, 2021 ), which also facilitate the synthesizing of metallic silver. Moreover, Cephalotaxus species have also gained attention for pharmacokinetics and drug metabolism.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of novel metallic silvers on kraft papers using cephalotaxus harringtonia fruit extract as a sustainable stabilizing agent (KP@AgNP)

Wei

Liu

Xie

et al. 2022

Front. Bioeng. Biotechnol.

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Greenly synthesized silver nanoparticles (AgNPs) on different cellulosic materials show tremendous potential for colorful, biocidal, and reasonably strong products by replacing the traditional chemical-based synthesis protocols. This study reports on a novel in situ synthesis protocol for synthesizing green and sustainable AgNPs over cellulosic kraft paper substrates using a bio-based stabilizing agent (Cephalotaxus harringtonia fruit extract). The protocol could play a significant role in packaging industries. The aqueous extracts of Cephalotaxus harringtonia fruits have been used to synthesize the metallic silver. The deposited AgNPs values were investigated through XRF (X-ray fluorescence) analysis. The number of deposited nanoparticles (NPs) was 268 ± 7, 805 ± 14, and 1,045 ± 16 PPM, respectively for 0.5, 1.5, and 2.5 mm silver precursors. The developed products were tested with SEM (scanning electron microscopy), SEM-mediated elemental mapping, EDX (energy disruptive X-ray), FTIR (Fourier transform infrared spectroscopy), and XRD (X-Ray diffraction). XRD analysis further confirmed the presence of peaks for elemental AgNP on the deposited papers. Colorimetric values were measured to confirm the colorful appearances of the developed metallic silvers. Mechanical properties were tested in terms of the tensile index and bursting index. Moreover, the statistical analysis of coefficient of variations (R2) and a post-hoc ANOVA test that adopted the Newman-Keul methodology also confirm the significance of developed nanoparticles in the papers. The shielding capacity against UV light was also investigated; all the AgNPs-treated products provided values higher than 40, demonstrating the strong UV resistance capability of the kraft paper material. Overall, the study confirms a successful development of green AgNPs on paper materials.

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Cephalotaxine-type alkaloids with antiproliferation effects from the branches and leaves of Cephalotaxus fortunei var. alpina

Cited by 7 publications

References 27 publications

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei

Cephalotane‐Type Norditerpenoids from Cephalotaxus fortunei var. alpina

Biosynthesis of novel metallic silvers on kraft papers using cephalotaxus harringtonia fruit extract as a sustainable stabilizing agent (KP@AgNP)

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