Cephazoline sodium release from poly(N‐isopropyl acrylamide‐co‐N,N‐dimethylacrylamide) hydrogels

Abstract

Hydrogels are hydrophilic polymers that swell to an equilibrium volume in the presence of water, preserving their shape. The dynamic swelling behavior of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [poly(NIPA-co-DMA)] copolymers at 37°C was investigated. It was observed that the swelling degree in the copolymers decreases with the N-isopropylacrylamide content. In addition, the liberation mechanism was found to be Fickian. Diffusion coefficients according to FickЈs law as a function of the N-isopropylacrylamide concentration and results of the release process are reported. The kinetics of cephazoline sodium release from poly(NIPA-co-DMA) hydrogels with different compositions was studied.

Synthesis and properties of new thermosensitive polymer systems

“…31 Special morphologies for pNIPAM-based thermoresponsive materials such as hydrogel nanoparticles, 32 poly(l-lactic acid) microcapsules as a pNIPAM gel container, 33,34 shell-crosslinked vesicles, 35 and an interpenetrating network with gelatin 36 were studied. These types of phase transition polymers are preferentially investigated for applications in biology and medicine for use in drug delivery systems, 1,13,32,33,35 carriers for gene delivery, 3 thermosensitive superabsorbents, 2 determination of enzyme concentrations, 16 and control of enzymatic activity. 37 We sought to develop thermosensitive gel particles for the discharge of aqueous solvent mixtures by gel collapse.…”

Effect of temperature and pH on swelling behavior of hydroxyethyl cellullose-acrylamide hydrogel

“…There exists interest in these areas for materials with liberation capacity of active substances in an efficient way [1].…”

Peroxide‐Containing Chitosan Derivative for Hydrogel Synthesis

“…Equilibrium swelling of Chi‐PVP hydrogels in aqueous media at different pH was calculated using Eq. 4:9 where Es ‐ equilibrium swelling of Chi‐PVP hydrogel, g/g, W E and W D ‐ weight of the swollen and dried sample, g.…”