Cephem sulfones as inactivators of human leukocyte elastase. II. Keto-enol tautomerish in cephem-4-ketones.

Dapson in Heterocyclic Chemistry, Part IV: Synthesis of Some Novel Diphenylsulfones Containing Acetamide, Pyrrolidine, Piperazine, and Thiomorpholine Moieties as Antimicrobial and Antitumor Agents

“…[1][2][3][4][5] Some pyrrolidine, thiomorpholine and piperazine derivatives are well known as cytotoxic [6][7][8][9] with radioprotective activity. [10][11][12] As a part of our studies on new heterocyclic compounds as new potential antitumor and radioprotective agents, we synthesized and tested some new diphenylsulfone derivatives.…”

Expeditious Synthesis of 4-(tert-Butylcarbonyl)-7α-methoxy-3-methyl-Δ3-cephem 1,1-Dioxide. Convenient Access to 7-Substituted Analogues

“…In the preceding paper 1 we pointed out the pivotal role of 4-benzoyl-7αmethoxy-3-methyl-∆ 3 -cephem 1,1-dioxide 1 and its 4-tertbutylcarbonyl counterpart 2 in the preparation of potent inhibitors of mammalian serine proteinases, 2,3 and described an innovative synthesis to obtain 1. An improved method of synthesising 2, and the exploitation of versatile intermediates for the introduction of various substituents at cephem C-7 position, are dealt with in the present paper.…”